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CD38 gets in the way of NR and NMN for increasing NAD+

Started by Michael Lustgarten , Feb 02 2021 10:49 AM
cd38 nad+ nmn aging longevity

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#1 Michael Lustgarten

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Posted 02 February 2021 - 10:49 AM


NR and NMN are popular ways to try to boost levels of NAD+, but that approach hasn't worked every time in human studies. One reason for that may involve CD38, which degrades both NR and NMN. With the goal of boosting NAD+ levels during aging, why does CD38 increase with age, and what can be done about it?


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#2 Mind

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Posted 02 February 2021 - 04:50 PM

Interesting connection with LPS and endotoxins. Thanks for sharing.


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#3 Heisok

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Posted 02 February 2021 - 10:01 PM

There have been other threads discussing CD38 inhibition. Hopefully some more great information will also be shared in this thread.

 

Links to two of several:

 

https://www.longecit...ne/#entry847892

 

https://www.longecit...-consumer-cd38/


Edited by Heisok, 02 February 2021 - 10:01 PM.

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Also tagged with one or more of these keywords: cd38, nad+, nmn, aging, longevity

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