CD38 gets in the way of NR and NMN for increasing NAD+

#1 Michael Lustgarten

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Posted 02 February 2021 - 10:49 AM

NR and NMN are popular ways to try to boost levels of NAD+, but that approach hasn't worked every time in human studies. One reason for that may involve CD38, which degrades both NR and NMN. With the goal of boosting NAD+ levels during aging, why does CD38 increase with age, and what can be done about it?

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#2 Mind

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Posted 02 February 2021 - 04:50 PM

Interesting connection with LPS and endotoxins. Thanks for sharing.

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#3 Heisok

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Posted 02 February 2021 - 10:01 PM

There have been other threads discussing CD38 inhibition. Hopefully some more great information will also be shared in this thread.

Links to two of several:

https://www.longecit...ne/#entry847892

https://www.longecit...-consumer-cd38/

Edited by Heisok, 02 February 2021 - 10:01 PM.

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#1 Michael Lustgarten

#2 Mind

#3 Heisok

Also tagged with one or more of these keywords: cd38, nad+, nmn, aging, longevity

active sex life with heightened longevity of a eununch

Are NAD+ precursors worth taking at this stage in the science?

Philosophisches Forum, Wollen wir ewig leben?

NAD+ Boosting Is Less Effective as We Age

Is motor neuron loss the true biological ceiling of human lifespan?

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