I've been researching the relationship between NAD+ levels and mitochondrial function, and wanted to share some thoughts and get input from this knowledgeable community.As we age, NAD+ levels decline significantly - some studies suggest up to 50% reduction by middle age. This decline appears to create a vicious cycle with mitochondrial dysfunction:1. Lower NAD+ impairs mitochondrial electron transport chain efficiency2. Dysfunctional mitochondria produce more oxidative stress3. Oxidative stress further depletes NAD+ through PARP activation4. The cycle continues...What I find particularly interesting is the emerging research on NAD+ precursors (NMN, NR) and their potential to break this cycle. Some key questions I'm exploring:- How significant is the bioavailability difference between various NAD+ precursors?- What's the optimal timing for supplementation relative to circadian rhythm?- Are there synergistic compounds that enhance NAD+ metabolism?I've been reading some promising research on this topic. For those interested in the science, I found this resource helpful for understanding the cellular mechanisms: https://www.glunovab...om/scienceWould love to hear your experiences and thoughts on NAD+ supplementation protocols. Has anyone noticed improvements in energy or recovery with consistent NAD+ support?
