Well, niacinamide is known to be a sirt1 antagonist. (sirtuin inhibitor)
look HERE
Some highlightsTry this PubMed search string:
(sirtuins OR sir2 OR sirt1) AND (niacinamide[tw] OR nicotinamide[tw])
See especially this report:
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in
Saccharomyces cerevisiae. Nature. 2003 May 8;423(6936):181-5.
http://www.ncbi.nlm....t_uids=12736687
inositol hexanicotinate might be a better source.
FWIW, I don't consider Dr. Weil to be the most authoritative source.
I concur... also feel the same about Dr. Perricone. I find more of a commercial approach rather than the more science-based arguements of AOR. I don't feel there is a multi that compares to AOR's Multi Basics 3 or Ortho Core, but that's just how I think.