Fredrik, thanks for the update on your regimen & supplements. Speaking of lycopene, can I get your take on Super AOX Firm Moisturizer from Cellbone? I was thinking about giving this a try. "A light, rich moisturizing formula that contains 1.5% Lycopene, 1% CoQ10, 10% Matrixyl 3000 (palmitoyl pentapeptide-3/4) with Omega3 rich Inca Inchi oil." An alternative without the lycopene would be Isomers Matrixyl 3000 (Water/Aqua, Linum Usitatissimum (Linseed) Seed Extract, Glyceryl Polymethacrylate, Propylene Glycol, Glycerine, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Methylparaben, Propylparaben.) I'm looking for a Matrixyl 3000 product to include in the basic regimen you have outlined.
Also, I'm awaiting your "fun stuff" list that you talked about in an earlier post. Are you close to putting it together?
Barbara Benae
I´m still not convinced that these short fragment collagen peptides can penetrate the SC and If that would actually be beneficial. Fragmented collagen (that these peptides emulate), can theoretically both stimulate repair and inhibit collagen synthesis as they act as feedback messengers. It´s still unclear what they will do if they actually could penetrate the SC. All the studies you´ve seen, beside the silicon imprint, are cell culture studies. They mean nothing unfortunately.
I´m wary of recommending anything that isn´t backed by solid science but I would try the Olay Regenerist serum fragrance free (niacinamide + palmitoyl pentapeptide-3) with their micro-sculpting cream (niacinamide + palmitoyl pentapeptide-4). That way you would at least get the benefits of the niacinamide.
Personally, I´d try the Olay Definity line instead (niacinamide + acetyl glucosamine). Skin brightening + glycosaminoglycan stimulation + enhanced barrier repair. Sounds like a good adjunct to a retinoid regime.
Oh, the "fun" stuff was just some notes about elastin regeneration and hyaluronic acid stimulation. But most stuff about elastin can be found in the link I provided. One interesting tidbit, ascorbic acid actually inhibits elastin generation in experimental studies on fibroblasts. But the clinical relevance of this, if any, is unknown. It may be that topical ascorbic acid just inhibits non-functional (the result of UV-damage) elastin.
What we know is that topical C will not cause skin sagging, rather the opposite. My experience is that a retinoid + topical C can produce some skin firming after 6-12 months of use.
Edited by Fredrik, 27 August 2008 - 09:58 PM.