The items below were on my list.
Essential Fatty Acids, (8-12 “Mega” EPA with 4 “Mega” “Gla”)
Resveratrol
Indole 3 Carbinol w/resveratrol (1-2 caps/day)
Selenium (200 to 400mcg daily) [LEM 200mcg]
V-D (800iu per day) V-D-3 (800-400iu/day) [D-3 LEM 800iu]
I did not use Resveratrol, Indole 3 Carbinol or any of the fish-based omega-3's. I can't tell you why at the moment I chose other items over these. As I sift thru my notes and post, perhaps I will be able to say.
The selenium may be an overdose. Ideally you want 130-150 ng/ml. 237 mcg/day (37 from diet according to CRON-o-Meter, 200 from a SeMC supplement) gave me 150 ng/ml. The average American diet yields 106 mcg/day, so most people would need less than 200 mcg.
I believe that
DIM is preferable to I3C.
Arch Intern Med. 2008 Feb 25;168(4):404-10.
Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults.
Bleys J, Navas-Acien A, Guallar E.
Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA. jbleys@jhsph.edu
BACKGROUND: Selenium, an essential trace element involved in defense against oxidative stress, may prevent cancer and cardiovascular disease. We evaluated the association between selenium levels and all-cause and cause-specific mortality in a representative sample of US adults. METHODS: Serum selenium levels were measured in 13,887 adult participants in the Third National Health and Nutrition Examination Survey. Study participants were recruited from 1988 to 1994 and followed up for mortality for up to 12 years. RESULTS: The mean serum selenium level was 125.6 ng/mL. The multivariate adjusted hazard ratios comparing the highest (> or = 130.39 ng/mL) with the lowest (< 117.31 ng/mL) serum selenium level tertile were 0.83 (95% confidence interval [CI], 0.72-0.96) for all-cause mortality, 0.69 (95% CI, 0.53-0.90) for cancer mortality, and 0.94 (95% CI, 0.77-1.16) for cardiovascular mortality. However, based on spline regression models, the association between serum selenium levels and all-cause and cancer mortality was nonlinear, with an inverse association at low selenium levels (< 130 ng/mL) and a modest increase in mortality at high selenium levels (> 150 ng/mL). There was no association between serum selenium levels and cardiovascular mortality. CONCLUSIONS: In a representative sample of the US population, we found a nonlinear association between serum selenium levels and all-cause and cancer mortality. Increasing serum selenium levels were associated with decreased mortality up to 130 ng/mL. Our study, however, raises the concern that higher serum selenium levels may be associated with increased mortality.
PMID: 18299496