Well that is his choice...
Well, not exactly. I can't leave the State of Maine without the States permission.
Posted 23 July 2008 - 04:11 AM
Well that is his choice...
Posted 23 July 2008 - 04:16 AM
Oh, they approved it, along with my request that I be allowed to have my vitamins sent in. They were being pretty accommodating after they found out I really did have cancer. They were a little nervous about having me file a lawsuit for denying me medical care. I did after all go from July to December without treatment, even though I requested an x-ray in July after putting in a medical slip.to your letter requesting a different dietwhat was the response to it?
Response to the diet?
Posted 23 July 2008 - 06:46 AM
Edited by scorpe, 23 July 2008 - 06:50 AM.
Posted 23 July 2008 - 07:03 AM
would he be able to take resveratrol and participate in this at the same time?I would like to begin here by Thanking Missminni for being a proactive member and helping me with my battle against cancer. And also, to the very responsive anonymous donor who paid for a kilo of Resveratrol.
I will be spending much of the day here in the Resveratrol forum.
Hi THEFIRSTIMMORTAL.
There is also a hedgehog inhibitor program that has showed great success in fighting cancer (better than resveratrol)
http://www.clinicalt...0...ehog&rank=2
I have personally heard and seen testimonials regarding people in this trail. If you don't meet all the criteria then PUSH for "compassionate use only." Hope this helps
This is from a friend who just started the clinical trial.
"Findings: There is marked interval improvement. On the previous exam [xxx] there were too numerous to count markedly metabolically active skeletal lesions [cancerous tumors]. Almost all of these bone lesions have resolved."
"There is also marked interval improvement in lymphadenopathy in the chest. A mildly metabolically active reference lymph node between the trachea and left lung apex now measures 0.8 x 0.6 cm compared to 1.7 x 1.5 cm. There are a few small mildly metabolically active lymph nodes just posterior to the mid left clavicle that have also decreased significantly in size and metabolic activity."
"In the abdomen, there is no abnormal metabolic activity in the intra-abdominal organs. A previous 1.2 cm lymph node between the aorta and mid polar left kidney is no longer identified. No new lymph nodes are seen."
I can get you lots of documentation regarding cancer and SCLC and how it is related to the Hedgehog Pathway.
but he would have to stay in Maryland to participate
Well that is his choice... Either try a supplement/starving or try something that has been specifically tested on SCLC animal models the choice is his. Plus there are min side effects seen in phase I and phase II... Treatment would be free because of a clinical trial... If nothing else is working it might be worth taking a look at and at least a call. There are already people using this drug for "compassionate use"
Posted 23 July 2008 - 08:40 AM
Posted 23 July 2008 - 11:47 AM
Oh, they approved it, along with my request that I be allowed to have my vitamins sent in. They were being pretty accommodating after they found out I really did have cancer. They were a little nervous about having me file a lawsuit for denying me medical care. I did after all go from July to December without treatment, even though I requested an x-ray in July after putting in a medical slip.to your letter requesting a different dietwhat was the response to it?
Response to the diet?
Posted 23 July 2008 - 02:50 PM
would he be able to take resveratrol and participate in this at the same time?
Posted 23 July 2008 - 02:51 PM
I meant political in the pharmaceutical community, which I clearly stated....not among politicians. True such natural substances cannot be pateneted but they can be synthesized and those synthetic versions can be patented and then the natural substanceI suspect that using Resveratrol for cancer might be a political hot potato in the pharma community. After all the current chemo treatments and cancer pharmaceuticals generate $42 billion in business a year. I thought that might even be the reason that sirtris is pursuing its use for diabetes 2 instead. One wouldn't infringe on any major existing market that way. JMO
I'm not sure why you think "using resveratrol for cancer" would be a political "hot potato". Unlike stem cell, etc. research, I can't imagine it offending many politicians. As far as its potential to "infringe" on existing products or products in development by pharmaceutical companies, it can't and won't. Natural substances such as resveratrol cannot be patented.
Resveratrol does have the potential to compete with existing and future patented pharmaceutical products, and for this reason pharmaceutical companies may not be interested in funding research into resveratrol's cancer fighting potential, but that's not relevant to my initial post in this thread.
Posted 23 July 2008 - 03:48 PM
Posted 23 July 2008 - 04:44 PM
Edited by TianZi, 23 July 2008 - 04:46 PM.
Posted 23 July 2008 - 06:28 PM
What can I say Missminni. You got a better chance of seeing God than seeing me give up cheese.Cheese might not be such a great thing to eat. It's too intense.
well then, you might just give up cheese
A question: if you eat cheese, which is dairy, why won't you eat yogurt or drink milk?
I ask because yogurt is an excellent way to take Res. You get the benefit of whey protein and acidophilus.
And dare I tell you about mixing it in Jack Daniels? I did that when I first started...it is quite an excellent method.
Maxwatt can back me on that. That would certainly add some calories to your diet.Yes, all sugar, but like I said, a very temporary thing just to bump my weight up quick.and those mini chocolate chips are all sugar no?
there are better ways to gain weight...nuts for one. lots of calories in nuts.
and if you are craving something sweet, try sweetening with agave or maple syrup. The refined white sugar
they use in chocolate chips is pure poison. Sorry if I'm sounding like a nagging mom.
Posted 23 July 2008 - 08:04 PM
Edited by theone, 23 July 2008 - 08:07 PM.
Posted 23 July 2008 - 08:51 PM
This is amazing. Wonderful. With this and Res he would be home free."American researchers will soon start a human trial to determine whether a treatment that can eradicate cancer in mice will do the same in people.
In the animal studies, white blood cells from cancer-resistant mice cured all lab mice who had malignant tumours. The cells have also been able to kill cervical, prostate and breast cancer tumour cells in Petri dish" tests.
"All the mice we treated were 100 per cent cured," lead researcher Dr. Zheng Cui told CTV News. "So that was very surprising for us."
There also seem to be a correlation with Vitamin D and the amount of these Granulocytes the average a person may have. This also may work independently of Resveratrol. From my understating Resveratrol induces cells to commit suicide. These Granulocytes physically attacks the cancer cell's. You if can some how increase your Granulocytes count it would only be an added benefit.
http://www.ctv.ca/se...80627/20080628/
How Can Cancer Patients Participate?
Patients must meet the following criteria in order to become eligible for this research study:
* YOU ARE CAPABLE OF CARING FOR YOURSELF
* YOU ARE UP AND ABOUT FOR AT LEAST HALF OF THE TIME
* YOU DON’T HAVE DIABETES, SIGNIFICANT CARDIAC DISEASE AND/OR AN ACTIVE SERIOUS INFECTION
* YOU HAVE NOT USED IMMUNOSUPPRESSIVE AGENTS OTHER THAN STEROIDS WITHIN 30 DAYS OF THE TRIAL
* YOU ARE NOT PREGNANT OR NURSING
* YOUR LIFE EXPECTANCY MUST BE MORE THAN 6 MONTHS
* YOU HAVE NOT RECEIVED BONE MARROW/STEM CELL TRANSPLANTS
* YOU HAVE NO EVIDENCE OF BRAIN METASTASES
* YOU HAVE NOT RECEIVED TREATMENT WITH FLUDARABINE
* YOU DON’T HAVE A HEMATOLOGIC MALIGNANCY
* YOU CAN NO LONGER BENEFIT FROM CONVENTIONAL THERAPY
LIFT Research Study
Granulocyte infusion therapy has been traditionally used for treating neutropenia-related infections for over 30 years with excellent safety records. Since a significantly higher dose of granulocytes for each patient is proposed in our new cancer treatment, the primary goal of this clinical trial is to test whether the recipients can tolerate the proposed dose of granulocytes.
The main focus of the trial is the possibility of developing Transfusion-Associated Graft vs Host Diseases (TA-GVHD) and other potential side effects in the study subjects at higher doses of donor granulocyte.
Donor granulocytes per se are not known to produce TA-GVHD. However, granulocytes collected via apheresis may contain with some donor T-lymphocytes that in some rare occasions can produce various degrees of TA-GVHD in some individuals, especially the recipients with immune suppression. If possible, we will also make observations on the efficacy of this treatment on the study subjects with measurable diseases of cancer. We will recruit 22 cancer patients as study subjects for this trial.
This research study has met all regulatory requirements including approval by the Wake Forest University School of Medicine’s Institutional Review Board (IRB) and been granted IND (Investigational New Drug) status by the Food and Drug Administration (FDA). It is currently registered at clinicaltrials.gov and the PDQ database of National Cancer Institute.
Edited by missminni, 23 July 2008 - 09:43 PM.
Posted 23 July 2008 - 11:51 PM
Would melatonin help?
http://www.lef.org/m...elatonin_01.htm
Much more to be found on the net.
Posted 24 July 2008 - 05:02 AM
Hi MaxwattThat is grounds enough for a lawsuit, if you have heirs and all treatments fail; even if you survive, "pain and suffering" might be enough. Caught early enough, before metastasis, your condition could have been treatable. There may be a law firm willing to take it on contingency. Six months could have made all the difference.
Posted 25 July 2008 - 02:13 AM
The selenium may be an overdose. Ideally you want 130-150 ng/ml. 237 mcg/day (37 from diet according to CRON-o-Meter, 200 from a SeMC supplement) gave me 150 ng/ml. The average American diet yields 106 mcg/day, so most people would need less than 200 mcg.
PMID: 18299496
Posted 25 July 2008 - 02:33 AM
First Immortal,
This article may be of interest to you:
"In clinical trials, TNP-470 suppressed a surprisingly wide range of cancers, including metastatic cancers, and produced a few complete remissions. Trials were suspended in the 1990s because of neurologic side effects that occasionally occurred at high doses, but it remains one of the broadest-spectrum angiogenesis inhibitors known. Lodamin appears to retain TNP-470's potency and broad spectrum of activity, but with no detectable neurotoxicity and greatly enhanced oral availability."
Edited by thefirstimmortal, 25 July 2008 - 02:33 AM.
Posted 25 July 2008 - 05:35 AM
Posted 25 July 2008 - 10:30 AM
First Immortal,
This article may be of interest to you:
"In clinical trials, TNP-470 suppressed a surprisingly wide range of cancers, including metastatic cancers, and produced a few complete remissions. Trials were suspended in the 1990s because of neurologic side effects that occasionally occurred at high doses, but it remains one of the broadest-spectrum angiogenesis inhibitors known. Lodamin appears to retain TNP-470's potency and broad spectrum of activity, but with no detectable neurotoxicity and greatly enhanced oral availability."
Thank You for posting this information TianZi. I have a lot of info on angiogenesis. I thought I posted that info, but so far I could only find one post:
http://www.imminst.o...&...st&p=249872
Apparently I haven't place the other information on the site yet. I would be nervous about neurologic side effects of TNP-470 especially since there are so many chicken soup angiogenesis products available.
Posted 25 July 2008 - 09:31 PM
Could resveratrol be combined with megadoses of antioxidants like vitamin C and betacarotenes or would that counteract the beneficial effects?
Posted 26 July 2008 - 01:39 AM
How can you be comfortable with that amount if you've never measured your selenium status? You seem pretty harmed by something. Here's a second study that shows a selenium cancer U-curve.The selenium may be an overdose. Ideally you want 130-150 ng/ml. 237 mcg/day (37 from diet according to CRON-o-Meter, 200 from a SeMC supplement) gave me 150 ng/ml. The average American diet yields 106 mcg/day, so most people would need less than 200 mcg.
PMID: 18299496
Really? That’s the amount in LEM. I’m pretty comfortable with taking that amount. A few decades of that amount didn’t seem to harm me.
Posted 26 July 2008 - 04:15 AM
Posted 26 July 2008 - 06:22 AM
First Immortal,
This article may be of interest to you:
"In clinical trials, TNP-470 suppressed a surprisingly wide range of cancers, including metastatic cancers, and produced a few complete remissions. Trials were suspended in the 1990s because of neurologic side effects that occasionally occurred at high doses, but it remains one of the broadest-spectrum angiogenesis inhibitors known. Lodamin appears to retain TNP-470's potency and broad spectrum of activity, but with no detectable neurotoxicity and greatly enhanced oral availability."
Thank You for posting this information TianZi. I have a lot of info on angiogenesis. I thought I posted that info, but so far I could only find one post:
http://www.imminst.o...&...st&p=249872
Apparently I haven't place the other information on the site yet. I would be nervous about neurologic side effects of TNP-470 especially since there are so many chicken soup angiogenesis products available.
Posted 26 July 2008 - 11:29 PM
Here's a case study that could justify increasing your omega 3 intake.Essential Fatty Acids, (8-12 “Mega” EPA with 4 “Mega” “Gla”)
Posted 26 July 2008 - 11:55 PM
this is great news and so easy to do.Here's a case study that could justify increasing your omega 3 intake.Essential Fatty Acids, (8-12 “Mega” EPA with 4 “Mega” “Gla”)
Nutr Cancer. 2005;52(2):121-9.
Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histiocytoma of the lungs.
Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
Department of Biochemistry, College of Agriculture, Biotechnology and Natural Resources, University of Navada, Reno, NV 89557, USA. ronp@cabnr.unr.edu
We present a case of a 78-yr-old man with malignant fibrous histiocytoma with multiple lesions in both lungs. Following diagnosis, he declined conventional chemotherapy and elected nutritional intervention by increasing intake of omega-3 fatty acids and lowering intake of omega-6 fatty acids. We estimated that he consumed 15 g of the long-chain omega-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) per day, and the ratio of linoleic acid/long-chain omega-3 fatty acids in his diet was 0.81. Serial computed tomography scans and pulmonary x-rays revealed remarkably a slow and steady decrease in the size and number of bilateral nodules. He has no apparent side effects from consuming large quantities of fish and algae oils rich in DHA and EPA and he remains asymptomatic.
PMID: 16201843
Posted 27 July 2008 - 02:24 AM
I was just thinking about how I havent responded to this topic of detrimental happenstance. Then I asked myself why I dont seem to care much about this life extensionist and how hes dying. And not to mention, you, firstimmortal are a huge contributor here.
Death is the darkest, blackest most haneous of all evils.
Posted 27 July 2008 - 01:08 PM
To say that I was surprised by the lukewarm response from the community to this member's plight would be an understatement. When so much effort is placed on the discussion of anti-aging, fighting death, etc. and here is an individual who has only a handful of months or possibly weeks left of life yet we are on the bleeding edge of knowledge and in contact with some of the worlds foremost researchers on aging and particularly cancer treatment.
Posted 27 July 2008 - 01:29 PM
I agree.I was just thinking about how I havent responded to this topic of detrimental happenstance. Then I asked myself why I dont seem to care much about this life extensionist and how hes dying. And not to mention, you, firstimmortal are a huge contributor here.
Thank you for your candor and the courage to make mention of it.
To say that I was surprised by the lukewarm response from the community to this member's plight would be an understatement. When so much effort is placed on the discussion of anti-aging, fighting death, etc. and here is an individual who has only a handful of months or possibly weeks left of life yet we are on the bleeding edge of knowledge and in contact with some of the worlds foremost researchers on aging and particularly cancer treatment.
I refer to Professor Cui and his upcoming cancer treatment trial. Cui was recently a speaker at an event sponsored by his organization. Has enough been done to help get FirstImmortal into this program? Cui sounds like he is more interested in saving lives rather than making the statistics stack up for his research.Death is the darkest, blackest most haneous of all evils.
Death by aging and disease is a reuirement of evolutionary selection. The domain of evil lies solely in the deeds of man.
Perhaps if Dr. Cui took an interest in helping him on an individual basis, not as part of the trial, he could bypass that risk. If anyone here knows Dr. Cui or is part of that community, perhaps they could approach him about it. Or if Thefirstimmortal is interested, he could contact him and send his medical records to see if he can help him on an individual basis. Contact information for Dr. Cui is http://www1.wfubmc.e...faculty/cui.htmthe primary goal of this clinical trial is to test whether the recipients can tolerate the proposed dose of granulocytes.
The main focus of the trial is the possibility of developing Transfusion-Associated Graft vs Host Diseases (TA-GVHD) and other potential side effects in the study subjects at higher doses of donor granulocyte. Donor granulocytes per se are not known to produce TA-GVHD. However, granulocytes collected via apheresis may contain with some donor T-lymphocytes that in some rare occasions can produce various degrees of TA-GVHD in some individuals, especially the recipients with immune suppression.
Posted 27 July 2008 - 01:47 PM
The anonymous donor has not been in touch with him. That's why he's anonymous and wants to remain so.To say that I was surprised by the lukewarm response from the community to this member's plight would be an understatement. When so much effort is placed on the discussion of anti-aging, fighting death, etc. and here is an individual who has only a handful of months or possibly weeks left of life yet we are on the bleeding edge of knowledge and in contact with some of the worlds foremost researchers on aging and particularly cancer treatment.
As a two month old member my opinion is probably not worth much but here goes anyway.
Thank you Mygenus and Missminni for speaking the mind of perhaps a few others. I do know that some members have been in touch with thefirstimmortal privately. Missminni, Mixter, Mygenus, Shepard and an anonymous resveratrol donor. Perhaps others that I am not aware so forgive me. However, my perception of the lack of member compassion for the most part has made me doubt my interest in Imminst. Is this just a community of leechers? I was so excited to find this forum and now I question the integrity here as demonstrated by the lack of moral responsibility.
Help me understand why a community so interested in LIFE appears to be unconnected from a long-standing member and contributor who is struggling for his LIFE! Have I missed something?
Edited by missminni, 27 July 2008 - 01:57 PM.
Posted 27 July 2008 - 07:46 PM
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