when taking Selegiline I cant take coffee?
I will try PPQ and see what it gives me but seems Ashwagandha is like a miniture Selegiline. What is GDNF responsible for?
At first that was my conclusion, that you should stay away from coffee... due to this:
http://www.springerl...x1/fulltext.pdf"There was a significant correlation between the AUC(desmethylselegiline)/AUC(selegiline) ratio and the paraxanthine/caffeine ratio (r = 0.41; P < 0.05), suggesting involvement of CYP1A2 in the formation of desmethylselegiline."
Upon further research, I found something strikingly different.
http://dmd.aspetjour...29/11/1480.longBasically, there are a host of other cytochrome p450 enzymes responsible for the breakdown of Selegiline, primarily
CYP2B6 (makes equal desmethyl / l-meth) and
CYP2C8 (makes slightly more desmethyl than l-meth) are of interest in formation of desmethylselegine. CYP2B6 and
CYP2C19 help clear the metabolites from the system. Thus, CYP2B6 is sort of a double edged sword. The study also mentioned that CYP1A2 was not a primary metabolizer and only accounted for less than 10% of overall metabolism of selegiline metabolites.
Thus, the best thing for making desmethylselegiline is to induce CYP2C8 and inhibit CYP2C19.
Ashwagandha is not very similar to Selegiline other than they both stimulate neurotrophic factors. I like taking them together. I find they have a wonderful synergy. Not everyone notices this, but I certainly am more lucid, level-headed, and less dizzy when taking Ashwagandha with Selegiline.
GDNF from WIKIPEDIA:
http://en.wikipedia....otrophic_factorThis gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung's disease.[2]
The most prominent feature of GDNF is its ability to support the survival of dopaminergic and motorneurons.
These neuronal populations die in the course of Parkinson's disease and amyotrophic lateral sclerosis (ALS). GDNF also regulateskidney development and spermatogenesis, and it affects alcohol consumption.[3]
Edited by devinthayer, 06 December 2011 - 03:10 PM.