The green area contains an amateur-tech approach anyone could make immediately
I think I read that lab mammals fed as much as they like with sulfur containg amino acids absent from their food had longevity gains like CR. Thus sulfur containing amino acids were the items linked to non-CR senescence.
I think that creating nonmetabolizable proteins which could cause the body to upregulate methionine as well as cysteine "removal" or "absorption" could cause the body to remove more of the sulfur containing amino acids from the normal food it digests possibly increasing longevity just as CR would. proteins are actually mostly digested to amino acids so it is possible some body mechanism that superscavenges sulfur containing amino acids might reduce their amount at the rest of the body.
One very simple approach is halogenating methionine or cysteine. When research pharmacologists halogenate a molecule at particular areas it makes them resistant to various metabolic enzymes. Typically a halogenated drug has a plasma half life 3 to ten times longer than the nonhalogenated form. Thus a physiology would think Chlorocysteine means an overabundance of cysteine
-> remove or excrete cysteine -> reducing the amount of cysteine circulating ->which mimics CR. Note that fluoruracil (another well researched halogenated amino acid) is a rather physiologically active chemical so halogenated sulfur containing acids might actually just be the first approach to creating a sulfur containg amino acid mimic that upregulates sulfur containing amino acid clearance,
Another approach, which is bizarre yet fairly plausible, is to immunize people against sulfur containing amino acids. I read about a cocaine vaccine that manages to sequester hundreds of milligrams of rapidly administered cocaine (snortfuls) to keep them from being detected at the brain. If immunology can actually sequester an entire half gram of sulfur containing amino acids at each meal, that sequesters a large pct of the circulating methionine as well as cysteine. Futher the cystein as well as methionine circulating between meals would also be minimized simulating CR during most hours of the day.
what do you think?
This has a very rapid technological prototype. CuSO4 is published as a general immunosensitizer at vaccine studies, thus reacting copper sulfate with methionine, then giving that to lab mammals would be a rapid amateur-tech approach to creating a new all you can eat CR mimic longevity drug.
Edited by treonsverdery, 18 May 2012 - 12:46 AM.
