19 replies to this topic

[renfr]

what do you think? anyone ever tried this bioavailable form of SOD? is it worth it?
I couldn't find proper studies on this except marketing stuff.
that's what I'm talking about :
http://www.iherb.com...eggie-Caps/7447
http://www.iherb.com...g-90-Vcaps/2486
http://www.iherb.com...60-Tablets/3350

any proof that SOD isn't very bioavailable?

[niner]

We can't prove that anything isn't bioavailable, under any and all circumstances, but we can prove that something is bioavailable, at least under the conditions tested. Generally speaking, our bodies consider proteins to be food, and have a lot of mechanisms for disassembling them in the GI tract. The body also doesn't like to allow macromolecules to pass from the gut to systemic circulation. All this having been said, it looks like the Glisodin guys have pulled off this trick, because Glisodin does appear to be bioavailable in a useful way. Maybe I should say "appears to be useful" since I don't know that it's ever been demonstrated that it works by increasing SOD levels directly, but it seems to have systemic antioxidant properties.

[Bonee]

it is all about the acid stability and resistance to protease of the enzyme, certain peptides like ricin,bean lectins and botulinum toxin passes easily the gi tract...

Edited by Bonee, 16 February 2013 - 02:28 PM.

[spermidine]

tried half a bottle and it never did anything worth. i say scam

[Kevnzworld]

GliSODin® is a water-soluble superoxide-dismutase extracted from a special strain of Cucumis melo LC (cantaloupe melon) chemically combined to wheat gliadin for efficacy after oral administration .
http://www.renerheal...ep deal web.pdf
Glisodin can potentially slow the progression of atherosclorosis as measured by cartoid IMT. Unfortunately many of the earlier studies done in 2007 were sponsored by the patent holder I suspect.
You can't expect this or most supplements " to do something " that you can feel. One would have to so a before and after cartoid IMT utrasound evaluation.
Quote: "After supplementation, SOD activity was significantly higher (p = .0037) in the supplemented group than the placebo group, and C-reactive protein was significantly (p = .00001) lower in athletes receiving GliSODin than those in the placebo group. In conclusion, supplementation with an extract rich in SOD activity promoted antioxidant status and protected against increased inflammation in the serum of professional rowers but had no effect on oxidative damage induced by exhaustive exercise."
http://www.ncbi.nlm....pubmed/21558574

[renfr]

GliSODin® is a water-soluble superoxide-dismutase extracted from a special strain of Cucumis melo LC (cantaloupe melon) chemically combined to wheat gliadin for efficacy after oral administration .
http://www.renerheal...ep deal web.pdf
Glisodin can potentially slow the progression of atherosclorosis as measured by cartoid IMT. Unfortunately many of the earlier studies done in 2007 were sponsored by the patent holder I suspect.
You can't expect this or most supplements " to do something " that you can feel. One would have to so a before and after cartoid IMT utrasound evaluation.
Quote: "After supplementation, SOD activity was significantly higher (p = .0037) in the supplemented group than the placebo group, and C-reactive protein was significantly (p = .00001) lower in athletes receiving GliSODin than those in the placebo group. In conclusion, supplementation with an extract rich in SOD activity promoted antioxidant status and protected against increased inflammation in the serum of professional rowers but had no effect on oxidative damage induced by exhaustive exercise."
http://www.ncbi.nlm....pubmed/21558574

this study is interesting indeed though it is not really an independent study.
I read on another thread that yourself used this supplement, why do you use it for and what did it bring to you?

tried half a bottle and it never did anything worth. i say scam

which brand?

[Kevnzworld]

I've used in the past in a supplement called endothelial defense by Life Extension. I recently had a cartoid artery thickness exam, and it showed no thickening. I'm reducing unnecessary antioxidant supplementation so I discontinued its use. If at some future point an ultrasound shows some developing atherosclorosis , I would consider taking it again.

[spermidine]

GliSODin® is a water-soluble superoxide-dismutase extracted from a special strain of Cucumis melo LC (cantaloupe melon) chemically combined to wheat gliadin for efficacy after oral administration .
http://www.renerheal...ep deal web.pdf
Glisodin can potentially slow the progression of atherosclorosis as measured by cartoid IMT. Unfortunately many of the earlier studies done in 2007 were sponsored by the patent holder I suspect.
You can't expect this or most supplements " to do something " that you can feel. One would have to so a before and after cartoid IMT utrasound evaluation.
Quote: "After supplementation, SOD activity was significantly higher (p = .0037) in the supplemented group than the placebo group, and C-reactive protein was significantly (p = .00001) lower in athletes receiving GliSODin than those in the placebo group. In conclusion, supplementation with an extract rich in SOD activity promoted antioxidant status and protected against increased inflammation in the serum of professional rowers but had no effect on oxidative damage induced by exhaustive exercise."
http://www.ncbi.nlm....pubmed/21558574

this study is interesting indeed though it is not really an independent study.
I read on another thread that yourself used this supplement, why do you use it for and what did it bring to you?

tried half a bottle and it never did anything worth. i say scam

which brand?

Glisodin@ its a trademark and its produced by only one company which is the creation of. rest is just various brands of supplements that use it and because its patent it is expensive.

[adamh]

If degradation in the gut is the main concern, what about other routes of administration? Transdermal, sublingual and insufflation come to mind. There is always im or sub q injection. That is, if the stuff really does work.

[niner]

If degradation in the gut is the main concern, what about other routes of administration? Transdermal, sublingual and insufflation come to mind. There is always im or sub q injection. That is, if the stuff really does work.

transdermal and sublingual sometimes work for very small molecules, but proteins are huge. Skin is, after all, designed to keep things out, not let things in. It's pretty good at that. Insufflation is better for some things, but again, small molecules are best there. To get proteins into the system, injection is the most reliable route. That said, glisodin doesn't seem to have that much of a problem, in that it does appear to work systemically. If it was naked SOD, it probably wouldn't work, but being complexed with gliadin seems to do the trick.

[platypus]

I've been on this stuff for a few years (SodZYME with Glisodin and wolfberry by LEF) and I'm now wondering if I should keep taking it. After all, there are more and more reports of antioxidants being much less useful for LE than what was believed a decade ago.

[niner]

It sounds like it may be good for some chronic inflammatory conditions, but the LE potential of glisodin is questionable. C60 is a lot cheaper if you want a powerful antioxidant, and there's even some evidence that it is good for LE, at least if you're a rat. Better than CR, in fact, based on the scant evidence available at this time.

[renfr]

I've been on this stuff for a few years (SodZYME with Glisodin and wolfberry by LEF) and I'm now wondering if I should keep taking it. After all, there are more and more reports of antioxidants being much less useful for LE than what was believed a decade ago.

how did it work out for you? do you feel anything? more energy, better skin, better health?

I think I will stick to my NAC for now.

[platypus]

I've been on this stuff for a few years (SodZYME with Glisodin and wolfberry by LEF) and I'm now wondering if I should keep taking it. After all, there are more and more reports of antioxidants being much less useful for LE than what was believed a decade ago.

how did it work out for you? do you feel anything? more energy, better skin, better health?

I take quite a few things so it's impossible for me to judge whether this has an effect. I can feel.I like to imagine that my skin is more resistant to sunlight but that might be just placebo or wishful thinking.

[tunt01]

I looked at this stuff for a day or two. I would never take it LT. I would take it before going in for a CT scan or something where I know I am going to be hit with a ton of ROS/damage.

I think this kind of product runs contrary to the underlying biological mechanisms of hormesis (stressors that induce a response of the human body which enhances performance, lifespan, etc.). Rather than upregulating your own endogenous antioxidant pathways through a stress-response process, it augments (or possibly replaces) your own antioxidant output. Given the lack of LT consumption data (all the studies I am aware of are short-term in nature), I think it's risky to take LT.

Edited by prophets, 21 February 2013 - 02:54 PM.

[renfr]

I looked at this stuff for a day or two. I would never take it LT. I would take it before going in for a CT scan or something where I know I am going to be hit with a ton of ROS/damage.

I think this kind of product runs contrary to the underlying biological mechanisms of hormesis (stressors that induce a response of the human body which enhances performance, lifespan, etc.). Rather than upregulating your own endogenous antioxidant pathways through a stress-response process, it augments (or possibly replaces) your own antioxidant output. Given the lack of LT consumption data (all the studies I am aware of are short-term in nature), I think it's risky to take LT.

What is LT?

[Kevnzworld]

Given the lack of LT consumption data (all the studies I am aware of are short-term in nature), I think it's risky to take LT.

What is LT?

Short for long term

[tunt01]

yes. Long term.

[tunt01]

To be clear, my concern is that by taking this supplement your own endogenous antioxidant output will diminish. Like many drugs, if you take them your own biological output can be altered (diminished and not necessarily enhanced).

I've had a conversation with a PhD anti-aging researcher about it and he also has a similar concern. His viewpoint was that unless you have a serious condition like lupus, it is not worth taking.

On the other hand, I have a relative who gets regular CT scans for lung cancer and I recommend this to them. If I had this product available to me during 9/11 when I was in New York City, I would have taken it for a couple of weeks probably.

[EFTANG]

Maybe I should say "appears to be useful" since I don't know that it's ever been demonstrated that it works by increasing SOD levels directly, but it seems to have systemic antioxidant properties.

 

 

I posted this reply in another thread: 

 

SOD is using gliadin (a component of gluten) as a carrier to form Glisodin. The other product is uncoated SOD which is useless because it will be destroyed in in the stomach. See this research abstract for comparison tests, and this full-text article for in-depth information.

 

I quote from the abstract: "The effects of supplementation for 28 days with a standardized melon SOD extract either combined (Glisodin) or not with gliadin, were evaluated on various oxidative-stress biomarkers. As already described there was no change either in superoxide dismutase, catalase or glutathione peroxidase activities in blood circulation or in the liver following non-protected SOD supplementation.

 

However, animals supplemented with Glisodin showed a significant elevation in circulated antioxidant enzymes activities, correlated with an increased resistance of red blood cells to oxidative stress-induced hemolysis."