Hello
I have done some experimenting on my self recently, trying different mixtures of C60, and I am very grateful for everyone's contribution on this site. I have noticed some difficult side effects from C60, which I currently have no knowledge of what is going on, just anecdotes.
The first "batch" of C60 I made, I noticed weird side effects. I had a calm that was mild in comparison to beta blockers, however strong enough to be noticed. I knew that I had anxiety from work so I began using a relatively low dose of C60 every day, to keep my mood good. This was working fine until I began to notice strange hyperactivity.. I would be sitting down and I would feel like I had to move, I assumed that this was because of having to much energy or something. I later found my self extremely depressed, however I could think completely clearly. The most troubling thing was that I would become agitated if I did not use C60. After I quite C60 because of the depression, I had difficulty coping with my life, this troubling effect was only exacerbated by the growing inability to maintain proper blood pressure and anxiety. I had difficulty paying attention because I was so furious, but I would never come down from my anger, my BP stayed at what ever level it was at all day. My veins literally felt like they were spasming all day, particularly around my heart.. it scared me but I thought that because I was no longer taking C60, the trouble would stop. I got a prescription for Selegiline and it has sort of brought my BP back to normal, right now I can think and I have the ability to focus. But the whole ordeal makes me believe that C60 has a important neurotransmitter like effect.
Some facts o support this theory-
-C60 causes Ca influx which is typically influenced by serotonergic mechanisms
-C60 made me depressed, anti dopaminergenic effects also point to a serotonin modulator effect.
-C60 made me spastic, I never determined what was making my veins feel like they were shaking, But because Selegiline reversed the effect, I assume it was some sort of hypertensive crisis I was going into.
-C60 shares a similarity to serotonin in that it is an antioxidant. Serotonin was originally used by some of our prehistoric organisms as such. During this time period C60 would have existed along with serotonin, perhaps in higher quantities than serotonin did during that time, although there are now receptors that C60 specifically binds to, it definitely makes an impact analogous to something endogenously produced. .
My advice is to not use C60 to much, if it modulates 5-ht receptors, overuse could lead to down regulation or up regulation of these receptors which could have drastic life long effects.
If anyone could give me some info on C60's effect on vasoconstriction and or hypertension, please comment.