38 replies to this topic

[medievil]

Looks like Gotu Kola does have GABAb-agonism:

This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor.

http://www.ncbi.nlm....pubmed/22112723


Ashwangandha also agonizes GABAb along with GABAa.., well it's actually considered to have "GABA mimetic" mechanism of action, but the GABAb affinity is definitely there as it works for Phenibut withdrawals.

I've been consuming full-spectrum Ashwagandha powder couple teaspoons a day after I run out of an extract. I feel it's smoother but the good qualities are still there. No rebounds or side effects.

So I still stand behind Ashwagandha + Gotu Kola for effective herbal anxiety treatment with minimal side effects. Throw some Rhodiola in there and it's pretty awesome.

I remember gotu giving me a anxiolytic feeling unigue to other stuff that benzo's couldnt give, i allways liked the stuff.

Chinese herbalist allways threw 100 things togheter, seems what you have to do with those herbs to get pharm like effects.

[Reformed-Redan]

Identified a whole bunch of herbal antipsychotics.

Strangely couldnt find a gabab herbal agonist, and i find everything hmm....

What kinds? Post 'em.

[medievil]

Biol Pharm Bull. 2005 Feb;28(2):224-5.
Neuroleptic-like properties of the chloroform extract of Maytenus obtusifolia MART. roots.

de Sousa DP, de Almeida RN.

Source

Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Caixa Postal 5009, CEP 58051-970 João, Pessoa, Paraíba, Brazil. damiao50@yahoo.com.br

Abstract

The effects of the chloroform extract of Maytenus obtufisolia MART. roots on locomotor activity, catalepsy test, amphetamine-induced toxicity and active-avoidance test were studied. The results revealed that the extract caused a decrease in spontaneous activity and induced catalepsy in mice up to 240 min. The extract significantly protected the mice against amphetamine-induced toxicity and decreased the conditioned response in rats, in a dose-related manner. The results suggest that the chloroform extract of Maytenus obtusifolia MART. possesses neuroleptic-like properties.

Loads of shit with hypothesises but also research on that one extract thats both a D1 agonist (working for negatives) and D2 antagonist working for positives, wich looks superior to other ap's, mate got so much work to catagorise everything it needs another ocd attack.

Edited by medievil, 09 March 2013 - 05:54 PM.

[medievil]

Looks like Gotu Kola does have GABAb-agonism:

This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor.

http://www.ncbi.nlm....pubmed/22112723


Ashwangandha also agonizes GABAb along with GABAa.., well it's actually considered to have "GABA mimetic" mechanism of action, but the GABAb affinity is definitely there as it works for Phenibut withdrawals.

I've been consuming full-spectrum Ashwagandha powder couple teaspoons a day after I run out of an extract. I feel it's smoother but the good qualities are still there. No rebounds or side effects.

So I still stand behind Ashwagandha + Gotu Kola for effective herbal anxiety treatment with minimal side effects. Throw some Rhodiola in there and it's pretty awesome.

Lets not forget tough nature has hidden one plant away wich is a strong selective ligand for a certain receptor, opium poppy's, muscimol, mariuana, its up to use to find the other and nature is good at hiding stuff with its like finding a needle. haha it does look like its the case doesnt it?

[protoject]

It's made by FutureBiotics, and it's called Stress-Assist. For some reason, the synergy of the compounds makes it a really effective anxiety supplement for me.

not sure if you have seen Ray Sahelian's products but I've been following him for a while and it seems like he might have a few good concoctions going, Ive never tried his products but he seems to have some interesting herbal combos Im considering.

[xsiv1]

It's made by FutureBiotics, and it's called Stress-Assist. For some reason, the synergy of the compounds makes it a really effective anxiety supplement for me.

not sure if you have seen Ray Sahelian's products but I've been following him for a while and it seems like he might have a few good concoctions going, Ive never tried his products but he seems to have some interesting herbal combos Im considering.

I've read through a vast portion of his site. I'm only critical of his diplomatic answering of certain questions but I do realize what or how he has to respond on a public forum.

[timhill88@outlook.com]

Hi

 

Its good we have a list of herbs but Im sure no body can be on same herb all their life so what would you guys say as a stack and duration and coming off them and detoxing maybe?? what do you think everyone help much appricated and im from UK would not mind organising a meeting in UK people with anxity and discuessing whats worked what hasnt and stacks and support from me too

[Flex]

 

Biol Pharm Bull. 2005 Feb;28(2):224-5.
Neuroleptic-like properties of the chloroform extract of Maytenus obtusifolia MART. roots.

de Sousa DP, de Almeida RN.

Source

Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Caixa Postal 5009, CEP 58051-970 João, Pessoa, Paraíba, Brazil. damiao50@yahoo.com.br

Abstract

The effects of the chloroform extract of Maytenus obtufisolia MART. roots on locomotor activity, catalepsy test, amphetamine-induced toxicity and active-avoidance test were studied. The results revealed that the extract caused a decrease in spontaneous activity and induced catalepsy in mice up to 240 min. The extract significantly protected the mice against amphetamine-induced toxicity and decreased the conditioned response in rats, in a dose-related manner. The results suggest that the chloroform extract of Maytenus obtusifolia MART. possesses neuroleptic-like properties.

Loads of shit with hypothesises but also research on that one extract thats both a D1 agonist (working for negatives) and D2 antagonist working for positives, wich looks superior to other ap's, mate got so much work to catagorise everything it needs another ocd attack.

 

 

wow this is interresting. I know just afew herbs with neuroleptic properties
 

[onemanatatime]

 

 

Biol Pharm Bull. 2005 Feb;28(2):224-5.
Neuroleptic-like properties of the chloroform extract of Maytenus obtusifolia MART. roots.

de Sousa DP, de Almeida RN.

Source

Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Caixa Postal 5009, CEP 58051-970 João, Pessoa, Paraíba, Brazil. damiao50@yahoo.com.br

Abstract

The effects of the chloroform extract of Maytenus obtufisolia MART. roots on locomotor activity, catalepsy test, amphetamine-induced toxicity and active-avoidance test were studied. The results revealed that the extract caused a decrease in spontaneous activity and induced catalepsy in mice up to 240 min. The extract significantly protected the mice against amphetamine-induced toxicity and decreased the conditioned response in rats, in a dose-related manner. The results suggest that the chloroform extract of Maytenus obtusifolia MART. possesses neuroleptic-like properties.

Loads of shit with hypothesises but also research on that one extract thats both a D1 agonist (working for negatives) and D2 antagonist working for positives, wich looks superior to other ap's, mate got so much work to catagorise everything it needs another ocd attack.

 

 

wow this is interresting. I know just afew herbs with neuroleptic properties
 

 

i invite any and all that may be of interest to upregulating GABA, treating PAWS, curing Anxiety naturally, or managing etc to join my thread ;

 

http://www.longecity...vity-naturally/

 

Together we can make a difference