Lest we not forget, spermidine has shown promise in reversing arterial plaque. Revisiting spermidine I find:
Mech Ageing Dev. 2013 Apr 20.
The Autophagy Enhancer Spermidine Reverses Arterial Aging.
Larocca TJ, Gioscia-Ryan RA, Jr CM, Seals DR.
Department of Integrative Physiology, University of Colorado, Boulder, Colorado, 80309.
Arterial aging, characterized by stiffening of large elastic arteries and the development of arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy, would improve arterial aging. Aortic pulse wave velocity (aPWV), a measure of arterial stiffness, was ∼20% greater in old (O, 28 months) compared with young C57BL6 mice (Y, 4 months, P<0.05). Arterial endothelium-dependent dilation (EDD), a measure of endothelial function, was ∼25% lower in O (P<0.05 vs. Y) due to reduced nitric oxide (NO) bioavailability. These impairments were associated with greater arterial oxidative stress (nitrotyrosine), superoxide production, and protein cross-linking (advanced glycation end-products, AGEs) in O (all P<0.05). Spermidine supplementation normalized aPWV, restored NO-mediated EDD and reduced nitrotyrosine, superoxide, AGEs and collagen in O. These effects of spermidine were associated with enhanced arterial expression of autophagy markers, and in vitro experiments demonstrated that vascular protection by spermidine was autophagy-dependent. Our results indicate that spermidine exerts a potent anti-aging influence on arteries by increasing NO bioavailability, reducing oxidative stress, modifying structural factors and enhancing autophagy. Spermidine may be a promising nutraceutical treatment for arterial aging and prevention of age-associated CVD.
PMID: 23612189 http://dx.doi.org/10...mad.2013.04.004
Full text attached.
A post about spermidine found in food stated:
Eat your peas.
Eisenberg et al, 2016. Cardioprotection and lifespan extension by the natural polyamine spermidine.
Nature Medicine. doi:10.1038/nm.4222
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan
of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic
function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial
respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding
with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed
to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In
Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart
failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and
prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart
failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires,
correlated with reduced blood pressure and a lower incidence of cardiovascular disease.
In July, 2019 Amazon sold 5 grams of the RPI spermidine product to me and sent it to my home. When I ordered directly from companies such as RPI they always required that it be sent to my business address, a large commercial facility. After I received the RPI product RPI sent a note to me telling me that they couldn't deliver to homes and told me to send it back to them.
From what I gather Amazon selling RPI spermidine to ship to homes was not allowed until recently.
This apparently means that Amazon will sell it and ship it to a person's home, and RPI can disclaim responsibility. Otherwise, RPI would lose a lot of business.
Is anyone here using spermidine or have you considered using it. Turnbuckle just posted that he is stocked up and, therefore, retains it in his protocol. In moving and such I had lost track of it.
