Wondering about thoughts on amphetamine and alterations in brain structure. I'm reading that amphetamine prunes DA neurons and leads to genetic and mitochondrial abnormalities that decrease future DA concentrations in the PFC. I've also read about the psychological dependence and the problems with tolerance reduction which is actually impossible since you are altering your reward pathways to the effects of an external compound. There's also the possibility of aortic tears from the cardiovascular stress induced by higher blood pressure from amp. Oh, yes there is also the decrease in synaptic plasticity from amp in PFC. To put it in short, it's like your burning your "candle" very hard and fast to get that extra sense of confidence and concentration.
Given my awareness of the above I really don't think it's worth taking or rationalizing taking Adderall for ADD. There are other methods, right? Modafinil is a good option I've heard. And if you really need that extra boost from amp, you can use it only on an as needed basis, like before/during a test? What do you think?