I've done a lot of GHB, both recreationally and as a sleep aid. I would say it's anti-nootropic on most counts, or perhaps more anti-executive-function. Lots of fun, though!
Looking over the papers linked here, I don't see a problem taking recreational doses in the weekends, but I'm definitely going to quit using it beyond the two-days-out-of-a-week mark as a sleep aid. I've suspected before I read this that 3-to-4-times-a-week, sub-dependency-threshold use was negatively affecting my executive attention. It seems the threshold for neurotoxicity is much lower than the threshold for dependency, which seems to require chronic use for a week or so, a line that I've never had need or desire to approach.
Take-away message seems that moderate recreational doses are least toxic, with low doses and knockout doses both being worse in their own way; and that with daily or near-daily use, taking 90% of every day off isn't protective against neurotoxic effects.The study in the second post injected this stuff daily, which means the rats spent only perhaps an hour of every day under influence.
Please don't mess with GHB. One of the most addictive drugs i've ever taken with the worst withdrawals I've ever had. Really not something to be playing with. Yes it seems so clean but once you get into daily dosing your screwed until you run out.
If you have strong willpower and don't have an addictive personality maybe it could be used safely but really your just playing with fire.
Maybe I do have those things, and maybe it helps that I've nothing to run from in my sober life, but I've never felt that I was playing with fire.
Still, it bears repeating for the audience: do not get into daily, consecutive redosing!
Edited by Raza, 18 June 2014 - 09:21 AM.