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Phenibut not working - am I doing it wrong?

phenibut gaba-b rectal administration absorption storage empty stomach

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#1 Vieno

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Posted 18 February 2014 - 05:47 PM


I have been doing experiments with phenibut every now and then for months, trying to make it work. It's something that might work for some of my pathologies so that's why the strong interest. The problem is that I can't get any effects from it. Might be that my GABA-B simply is completely nonfunctional - this could be the culprit of all my brain issues - but how likely is that? So I want to be sure I'm doing the testing right.

I've tried two brands, Primaforce and Mind Nutrition, and up to 15 grams on empty stomach, and have never gotten any effects. Let me list all the relevant info regarding my testing:

I did Primaforce up to 10g and Mind Nutrition up to 15g
I store the phenibut in its original container in a cool-ish (+~15C) and normally humid room
I take it always the first thing in the morning on completely empty stomach
I mix it with fleshy orange juice to cover the taste (about 1dl for every 3 grams of phenibut)
I do not eat until 4 hours have passed after the administration (to make sure I do not mess with the absorption)
I wait for days, usually a week between tests to avoid tolerance, and in total I have only made 8 tests during a period of over six months.

Can I possibly be doing something wrong? Anything I should change? Any tricks to try? Perhaps I should try rectal administration?

Thank you!

P.S. I know pharmacology and GABA-B quite well, just not going into anything too technical to keep it simple - after all, I'm now only interested in getting the phenibut working which is probably quite a practical matter.

E: I have had problems getting other drugs to work too, however usually a higher dose works and nothing seems this absolute as phenibut, except something that has been analyzed & sorta explained.

Edited by Vieno, 18 February 2014 - 05:48 PM.


#2 Epigenesis

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Posted 18 February 2014 - 06:00 PM

I find it fascinating and baffling how certain substances do not work on some people. Personally, I am in the opposite position, I react strongly to most substances. 500mg of phenibut was enough for me to have a noticeable and enjoyable effect. I can't imagine eating 15 grams of phenibut, I don't think I could stomach it. If 15 grams did nothing, then don't bother with rectal. Not only do I not think it would work for you, I think it would be extremely uncomfortable lol. I am sorry, but it doesn't sound like there is anything you can do differently.

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#3 Vieno

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Posted 18 February 2014 - 06:24 PM

There are indeed big differences in people's responses to drugs, however complete lack of reaction to a psychoactive substance regardless of the dose is extremely rare. Does it always or usually reflect a specific, often serious pathology - lack of function of the systems that the drug targets - or can it be related to the molecule in question in some absorption or metabolia related way, not its target systems?

What's puzzling is that phenibut is considered to be a weak GABA-A agonist too, and yet I'm not getting ANY effect from it. Even if my GABA-B receptors would be completely nonfunctional, there is absolutely no way that my GABA-A would be too, because I'd certainly be dead in that case, besides, benzos and alcohol do work for me.

It's a mystery but I'm not giving up on experimenting yet. You honestly think plugging 30 grams of phenibut to my ass won't do nothing? That'd be something. Nobody would believe me if I'd say I don't respond to something as well established as benzos or, say, amphetamine, but phenibut is a bit different as it's not so super famous, at least not outside Russia.

Edited by Vieno, 18 February 2014 - 06:28 PM.


#4 Epigenesis

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Posted 18 February 2014 - 06:33 PM

I don't know enough to answer those questions, I just think putting 30 grams of an acidic substance in your rectum would not be worth any possible possitive result.

#5 Vieno

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Posted 18 February 2014 - 06:37 PM

Heh... well I'll try a lower dose first to see how it feels like... some have reported super potentiation from snorting phenibut, like miniscule amounts have worked, maybe I'll try that too. Although I'm super sceptical.

Honestly, I do not think this is a matter of stomach absorption or first pass metabolism, but I need to be sure.

Edited by Vieno, 18 February 2014 - 06:38 PM.


#6 8bitmore

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Posted 18 February 2014 - 07:11 PM

Heh... well I'll try a lower dose first to see how it feels like... some have reported super potentiation from snorting phenibut, like miniscule amounts have worked, maybe I'll try that too. Although I'm super sceptical.

Honestly, I do not think this is a matter of stomach absorption or first pass metabolism, but I need to be sure.


To be honest I would move on to another substance if I were you - have had similar experience with quite a few 'strong' compounds that turned out to hit nothing for me whatsoever despite quite liberal dosing range (among the mentionables here are Sunifiram and Aniracetam).

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#7 Vieno

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Posted 19 February 2014 - 09:10 AM

I feel you and I will probably abandon this one soon. However I'd like to continue experimenting a little just to be sure. It seems impossible to me how resistant I am to substances. I won't accept that, I want to bombard my brain with huuuuuuuuge doses to see if anything happens.





Also tagged with one or more of these keywords: phenibut, gaba-b, rectal, administration, absorption, storage, empty stomach

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