337 replies to this topic

[ILIkeBeer]

Sage-547

It is a drug for seizures but apparently works well for depression... I do hope they test it for more then just post partum depression because it seems like it might be useful for us all!  Of the four women it cured them all in 60 hours... google it for some reason I can't post links!

 

 

 

 

[eon]

Yeah I just read about this one too yesterday. 

 

Sage-547

It is a drug for seizures but apparently works well for depression... I do hope they test it for more then just post partum depression because it seems like it might be useful for us all!  Of the four women it cured them all in 60 hours... google it for some reason I can't post links!

 

[nicklesprout]

it is an allosteric modulator of the GABAA receptor, can that be a good thing??? like a benzo? sheesh i hope not.

[Strangelove]

There is currently any group buy running for any of these drugs discussed in the first page?

 

I have not read the whole thread, but the first page seems very interesting! According to the effects described I found Mi-4 and anavex 1-41 something I am interested to try.

 

Also Kor antagonists are pretty interesting for anxiety and depression as you probably discussed already. There is an effort for a group buy.

 

http://www.longecity...or-a-group-buy/

Below is advertisement from Team TLR really, but from previous research I am pretty sure there are big potentials for Kor antagonists investigated currently.

 

Theories Behind KOR Antagonist Treatment and KORX-OX

KORX-OX as a long-acting KOR antagonist activity, in similar fashion to JDTic and other long-acting KOR antagonists, is theorized to alleviate psychoneurodysfunctional [Google it] states (moderate to severe), within a broad range of conditions, including states that encompass depression states, anxiety/fear/trauma states, OCD-S states, addiction states, depersonalization-related states, and other such psychoneurological/emotional states adverse to well-being.

The opioid system is the seat within the balance set within evolutionary 'design' of wellness:unwellness, and most all that is encompassed within such. Within that theory, currently proposed theory denotes the potential of direct antagonist activity upon KOR, the “seat of unwellness”, to foster a potent counter to this opioid receptor that is responsible for 'negative-state' promotion.

Antagonizing the receptor would appear to have no tolerance and addiction potential as with the induction of agonist activity of MOR, the “seat of wellness”, wherein such modalities are not viable as within bearing the intrinsic flaws of rapid tolerance and high addiction potential (among other well-known non-psychoactive adverse effects).

Quite to the contrary, KOR antagonist activity is anti-tolerance and anti-addiction, providing 'resetting' of “emotional tone” primarily through resetting of these pathways; within markedly reversing dysregulation within dopaminergic pathways and other addiction-related/tolerance-related pathways.

“Emotional Tone” or “Psychoneurofunctional Tone” is the level of resistance to adverse/dysfunctional emotional states (psychoneurodysfunctional states, which as well encompasses addiction states).   KORX-OX in in vivo animal research has demonstrated long-acting effects (naturally tapering of effects appear to remain for 1-3 weeks after cessation of KORX-OX depending on the dose and duration of administration) within its KOR antagonist activity.

To have capacity to so profoundly improve core(KOR) tone would appear to be of greatest value as a base treatment for improving a plethora of psychoneurodysfunctionalities.

KORX-OX may be the breakthrough many are looking for within research of all paradigms with a strong underlying 'stress' component such as depression states, anxiety states, OCD and ASD states, addiction states, et. al.

Edited by Strangelove, 13 June 2015 - 05:08 PM.

[Aurel]

Antalarmin is a CRH antagonist (mentioned on the first page) and decreases anxiety. When googling for it I found a study suggesting that a dose of quercetin can have the same effect on the CRH mechanism:

 

http://www.wellnessr...and_depression/

[Strangelove]

Supposedly the new controlled release tianeptine sulfate its a good option for an antidepressant also.

 

I may arrange a group buy if I find it in a good price!

[eon]

powdercity could easily get this cheaper if we all send them a quick product request. They already sell tianeptine anyway. I will e-mail them now.

 

Supposedly the new controlled release tianeptine sulfate its a good option for an antidepressant also.

 

I may arrange a group buy if I find it in a good price!

 

[Strangelove]

 

powdercity could easily get this cheaper if we all send them a quick product request. They already sell tianeptine anyway. I will e-mail them now.

 

Supposedly the new controlled release tianeptine sulfate its a good option for an antidepressant also.

 

I may arrange a group buy if I find it in a good price!

 

 

Sounds good!

[ILIkeBeer]

eTNS (external trigeminal nerve stimulation) - I am not sure if I posted this before but if so I totally forgot about it.  Apparently you wear it all night long every night.  In a study patients had between a 30% and 42% reduction in depression after 6 weeks.  The best part however is that it is all self-administered.

 

 

http://www.medscape....article/847686 

 

[eon]

page not found.

 

eTNS (external trigeminal nerve stimulation) - I am not sure if I posted this before but if so I totally forgot about it.  Apparently you wear it all night long every night.  In a study patients had between a 30% and 42% reduction in depression after 6 weeks.  The best part however is that it is all self-administered.

 

 

http://www.medscape....article/847686 

 

[ILIkeBeer]

There is a brand new compound... not sure exactly what, they say it is an inhibitory compound called GABA... while I have heard of GABA before they say it got rid of depression in 24 hours!

 

 

http://medicalxpress...pidly-side.html

 

[Duchykins]

There is a brand new compound... not sure exactly what, they say it is an inhibitory compound called GABA... while I have heard of GABA before they say it got rid of depression in 24 hours!

 

 

http://medicalxpress...pidly-side.html

 

 

...are you for real?

[Duchykins]

I don't get it...I am clearly serotonin deficient due to my utter miserable feelings and positive reaction to some serotonin acting drugs as well as st John's wort.

But I also have incredible fatigue, low motivation and basically all symptoms of low noradrenaline...but when I take wellbutrin or lofepramine, two pills with strong affinity for noradrenaline, I'm stupidly anxious. Like physically uncomfortable anxiety. Although mirtazapine was amazing for motivation, best I've ever felt motivation wise. It also has strong noradrenaline affinity but much more as well I suppose which may have been the source of my positive reaction in terms of motivation, energy etc.
I think above study is oversimplified just like the way they believe antidepressants etc work

 

That's because you don't have low norepinephrine.  That article was full of shyte and spelling errors.

 

Shortness of breath, choking sensation, fatigue and all that can easily be caused by elevated norepinephrine or lowered serotonin (so that there is not enough to keep norepinephrine in check).  It's called anxiety.  Anxiety can literally make you exhausted and lethargic,by the way.  It's taxing on the whole body.

[ILIkeBeer]

 

There is a brand new compound... not sure exactly what, they say it is an inhibitory compound called GABA... while I have heard of GABA before they say it got rid of depression in 24 hours!

 

 

http://medicalxpress...pidly-side.html

 

 

...are you for real?

 

 

I thought I was... it is a new article.. they don't fully explain what they are looking into, but they make it seem like it is something brand new and since I am not 100% sure what they are talking about it seems like it could be exciting.  What is your problem with the article?

[Duchykins]

 

 

 

I thought I was... it is a new article.. they don't fully explain what they are looking into, but they make it seem like it is something brand new and since I am not 100% sure what they are talking about it seems like it could be exciting.  What is your problem with the article?

 

 

 

I have a growing problem with the cavalier manner people are taking articles from nonscientific sources seriously, especially when they misinterpret the articles and tell other people about it.

 

The media will always present new drugs as exciting.  There is always a spin.  But caution always needs to be practiced.  Science news articles, no matter their source, no matter what field of science, must be taken with grain of salt.  You are reading the journalists' interpretation of the study or its abstract, and they rarely quote anything in the studies themselves, and many times just like this, they won't even give the title of the paper.  

 

A lot of times, like this I suspect, the journalist never even laid eyes on the published study, they are instead going on tips from various sources, reporting on the activities they observe in the academic institution, taking cues from administrators, and interviewing people who worked on the project.  It's even easier for them to misinterpret something or just report it in a way that misleads readers (usually unintentionally, I believe, I'm not into conspiracy-like "they're misinforming to us on purpose" stuff).

 

When we are all here discussing things that affect our health and wellbeing, we need to be more vigilant, not less, and have a higher standard in our sources of information than we normally would have otherwise.

 

Science journalists get something wrong all the time.  It doesn't matter how reputable the media institution: Nat Geo, Discover, Scientific American, New Scientist, Popular Science, Wired, Time, you get the picture.  I see it all the frikken time and honestly it drives me batty.  It's a big pet peeve I've been nursing for years.

 

I'm not saying that whoever the author (unnamed) of the article you posted is wrong.  I'm saying you should not be jumping all over articles like this.

Edited by Duchykins, 14 July 2015 - 02:59 AM.

[eon]

if anyone can find GABA-NAMS let me know, I'd love to try it. About time they made different variation of GABA since GABA itself can't cross the blood brain barrier which is why Picamilon was made to cross the BBB (GABA and Niacin makes Picamilon). Now, let's all flood Powdercity with product request for GABA-NAMS.

[Duchykins]

They don't say the new compounds are variations of GABA.

 

"Because there is no safe way to directly strengthen excitatory communication, they examined a class of compounds that reduce the inhibitory messages sent via GABA. They predicted that these compounds would restore excitatory strength. These compounds, called GABA-NAMs, minimize unwanted side effects because they are precise: they work only in the parts of the brain that are essential for mood."

 

They would be a type of GABA inhibitor or blocker.  This would decrease GABA's modulation of glutamate.  Glutamatergic system would be more active.  They think this could abolish some kinds of depression.

 

I'm sure some people would be helped with this.  I'm sure others wouldn't be able to tolerate it since their depression is linked to low GABA activity, high glutamate activity.

 

[Duchykins]

In fact I can already see a list of potential side effects for a drug like that:

 

anxiety

irritation

insomnia

tremor

tinnitus

headache

seizure

[Joe Monroe]

hey I read about that article yesterday as well and figured I'd come here. Yeah not sure how many people it would work for, who knows it could help a lot I'm sure but doesn't actually seem that much of a breakthrough as I first expected. 

 

I just know that when I did low dose ketamine, which is supposed to help stimulate other areas of the brain and relieve depression it just made me feel more out of it, didn't help at all. I feel my situation is pretty unique though. 

[ILIkeBeer]

Ok I guess my last post was crappy but I think this one fits the bill even more...  I do not know if it is a breakthrough but it is kind of funny.  Apparently you can make someone depressed by putting depressed people's poop in their intestines... here is a link.

 

http://www.irishcent...scientists.html

 

[Duchykins]

Ok I guess my last post was crappy but I think this one fits the bill even more...  I do not know if it is a breakthrough but it is kind of funny.  Apparently you can make someone depressed by putting depressed people's poop in their intestines... here is a link.

 

http://www.irishcent...scientists.html

 

 

What the actual fuck?

 

Look this article says:

 

The researchers tested their theory on rats.

The rats’ microbiota was cleared using antibiotics and then a fecal transplant was given from a human donor with clinical depression.

The rats began to show signs of depression and anxiety, and experienced weight loss and fatigue.

So, what they did was take healthy rats, give them antibiotics to wipe out their own natural flora (which alone can make them exhibit depressive symptoms) and then transplanted human feces in there?  I don't even want to know how they did that.

 

Humans with very different diets, hormone balances, and all that?  I bet that rat was slammed with estrogen at the very least, which we all excrete through solid waste.  And someone who is depressed could easily have an excess of estrogen.

 

I bet they did not have a control rat with feces from a human who was not depressed.

 

This whole thing is smells bad (no pun intended).

[Duchykins]

I just looked at the comments on that article.  There is a guy there talking sense, saying "this article is contradicted by recent condemnations in science media about the unregulated use of this treatment.  It is awaiting moderation and will probably be deleted."

 

 

I just put something saying that this article is contradicted by recent condemnations in science media about the unregulated use of this treatment.  It is awaiting moderation and will probably be deleted.I just put something saying that this article is contradicted by recent condemnations in science media about the unregulated use of this treatment.  It is awaiting moderation and will probably be deleted.I just put something saying that this article is contradicted by recent condemnations in science media about the unregulated use of this treatment.  It is awaiting moderation and will probably be deleted.

 

I just put something saying 

[eon]

I just need some GHB.

[Duchykins]

Is anyone using coluracetam for this?

[eon]

For depression? Not sure. I've never tried the compound but on another thread I participate in there was a talk of coluracetam about being potentially great for people with ADHD. I haven't tried it yet.

 

Is anyone using coluracetam for this?

 

[jefferson]

The pharma pathways I believe hold the most promise as of right now are: glutamate antagonism/modulation ala ketamine or glyx-13, kappa antagonism from alks-5461 or cerc-501 which we are trying to arrange a group buy for, and small molecule neurogenic drugs like NSI-189.

 

There is another option that nobody talks about, but has been making incremental progress. That option is electroconvulsive therapy. ECT has response rates as high 90% in treatment naive patients, and 50% in treatment-resistant. Honestly, it blows everything else out of the water at this point, perhaps only Ketamine can compare. tDCS or rTMS will never replace ECT because neither produce a seizure, which is critical. The seizure somehow elicits a compensatory neurotrophic response in the brain. Once they get the memory side effects sorted out, and I think they will eventually (although with the meager funding it could take another 50 years), this will become a lot more popular for very intractable sufferers.

 

BACKGROUND:

Electroconvulsive therapy (ECT) remains the most effective acute treatment for severe major depression, but with significant risk of adverse cognitive effects. Unidirectional electrical stimulation with a novel electrode placement and geometry (Focal Electrically Administered Seizure Therapy (FEAST)) has been proposed as a means to initiate seizures in prefrontal cortex prior to secondary generalization. As such, it may have fewer cognitive side effects than traditional ECT. We report on its first human clinical application.

→ source (external link)

 

There are also people talking about producing the seizure using anesthetic, which could produce the same high remission rates but without as serious memory problems.

Edited by jefferson, 19 July 2015 - 02:39 AM.

[eon]

what could be wrong with people who are "depressing" to be around with? Are they necessarily depressed or is it me that is the problem? My mother is "depressing". Only she can know how she is feeling though.

[Izan]

New drug treats depression in less than 24 hours with minimal side effects

 

 

http://www.scienceal...al-side-effects

[rena123]

Great Thread, thank you for creating it.

Just wondering how long it will take for those medications to actually become available to the broad public.

Also I'm pretty curious what scientists were doing the last 50-60 years, except for modifying and creating new kinds of SSRIs, since all those new types of medications are researched just now.

 

[ILIkeBeer]

Great Thread, thank you for creating it.

Just wondering how long it will take for those medications to actually become available to the broad public.

Also I'm pretty curious what scientists were doing the last 50-60 years, except for modifying and creating new kinds of SSRIs, since all those new types of medications are researched just now.

 

Some will take many years, as to what scientists were doing... I imagine a lot of time from the 80's through 2000 were spent doing research on SSRI's I am sure they thought that was it we cured depression.... at least for a bit.  I hear a lot of drugs do not make it through the FDA approval process so who knows how many of these breakthroughs will actually come to our homes one day..