3 replies to this topic
#1
Posted 04 June 2014 - 04:08 PM
Pathobiol Aging Age Relat Dis. 2014 May 23;4.
Ladiges W.
The quality control (QC) theory of aging is based on the concept that aging is the result of a reduction in QC of cellular systems designed to maintain lifelong homeostasis. Four QC systems associated with aging are 1) inadequate protein processing in a distressed endoplasmic reticulum (ER); 2) histone deacetylase (HDAC) processing of genomic histones and gene silencing; 3) suppressed AMPK nutrient sensing with inefficient energy utilization and excessive fat accumulation; and 4) beta-adrenergic receptor (BAR) signaling and environmental and emotional stress. Reprogramming these systems to maintain efficiency and prevent aging would be a rational strategy for increased lifespan and improved health. The QC theory can be tested with a pharmacological approach using three well-known and safe, FDA-approved drugs: 1) phenyl butyric acid, a chemical chaperone that enhances ER function and is also an HDAC inhibitor, 2) metformin, which activates AMPK and is used to treat type 2 diabetes, and 3) propranolol, a beta blocker which inhibits BAR signaling and is used to treat hypertension and anxiety. A critical aspect of the QC theory, then, is that aging is associated with multiple cellular systems that can be targeted with drug combinations more effectively than with single drugs. But more importantly, these drug combinations will effectively prevent, delay, or reverse chronic diseases of aging that impose such a tremendous health burden on our society.
PMID: 24891937
#2
Posted 20 June 2014 - 04:38 AM
Interesting,
Seems like a rehash of previous aging theories
I would imagine cycling these compounds would be necessary. Wouldnt want to take Propranolol on a daily basis given its possible side effects. Long term use of propranolol may sensitize BAR signaling, which is a counter productive result.
Many, many proteins act on AMPK as a down stream target. It plays a very central role. Heck even aspirin activates AMPK (
#3
Posted 19 August 2014 - 08:58 PM
Is phenyl butyric acid the same thing as the butyric acid produced by the microbiome?
#4
Posted 19 August 2014 - 09:22 PM
Is phenyl butyric acid the same thing as the butyric acid produced by the microbiome?
Nope. It's butyric acid with a phenyl group attached. There are a couple different isomers- you'll need to know which one they're talking about.
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