81 replies to this topic

[YoungSchizo]

Okay, well shit hit the fan and I've gone psychotic again. I'm on Latuda 37mg for a week now and it instantly reduced symptoms as from day 1. It's non sedating and seems like it works, unlike Zyprexa which I took for almost 10 years. Though, I'm a bit scared of the chance of getting EPS as a side-effect. So my question would be, is there a way to reduce this risk? Maybe an idea to drink some alcohol once in a while in order to (temporary) wash out Latuda? Or any idea's?

[Flex]

Nice to hear. Do You mean with EPS, tardive dyskinesias or acute ones ? tardive could be reduced by Ashwagandha or other antioxidants, the acute by afaik anticholinergic but this "could" cause confusion, amneisa & ect.

 

In regards of the wash out, I would look for something that activates CYP3A4 because according to wiki: Lurasidone is metabolized in the liver via the enzyme CYP3A4

http://en.wikipedia....wiki/Lurasidone

 

However, St. johns wort can have mixed effects i.e. sometimes or dosedependly inhibit this enzyme or dont have any great effect at all

-> google for it e.g. St. Johns wort + antikonzeptiva. Because this question is more common than for other meds.

 

[YoungSchizo]

I mean the chronic ones like tongue smacking and/or grimace-ing and that kind of freaky/scary side-effects
I mean the chronic ones like tongue smacking and/or grimace-ing and that kind of freaky/scary side-effects

[Flex]

Yes, then chronic use of antioxidants just look into ncbi like: tardive dyskinesia + herb(al) or something like that. Q10 could afaik help. In regards of Vitamin E and antioxidants in general: it could slightly(?) elevate the risk of cancer. in the case of Q10, its also prooxidant so this might be more out balanced.

 

Anyway, I will post tomorrow more.

Edited by Flex, 05 June 2015 - 12:30 AM.

[OneScrewLoose]

Latuda seems to have a lower risk of EPS than Zyprexa. I really like the pharmacological profile of Latuda, and I think it's a great advancement as for as antipsychotics go, and it's actually reasonably priced, which is rare for an antipsychotic as they normally charge $500-$1000 per month.

 

Have you had an EPS from what you've taken so far?

[YoungSchizo]

On Risperdal I had a restless leg-syndrome, I literally wanted to cut my leg off. On Zyprexa I had a muscle twitch in my arm once in a while.
Today, on Latuda I might start experiencing Parkinsonism, my nerves in my left hand/fingers started to tremple/twitch for almost an hour. Now, 5 hours later, I still feel some sort of "electricity"/discomfort in my hand nerves but the twitching has stopped luckily. It really worries me that it will continue or get worse as I hope that I won't have to go off Latuda.
As for the experience on Latuda so far, it's friggin' great compared to the AP's I tried. It works very well against positive symptoms, I still can be creative, my mind is clear, I don't stumple upon words like I did on Zyprexa, I speak a little less fluently but that's fine by me. My concentration slowly returns back to normal, though, time will tell if this also works a bit on cognitive symptoms. Latuda is non-sedative, a bit stimulating instead, which is positive (for negative symptoms) and negative as I don't get a good night rest and want to take a nap throughout the day which also is almost impossible. Another side-effect is that I crave more for sweet foods but I didn't gained any pounds and am able to have some control over this which was impossible on (a high dose) Zyprexa. On Zyprexa, even on a low dose, if you eat healthy and only as needed I still gained weight.

Anyway, I'll report back if the Parkinsonism continues or get worse.

[Flex]

Altough a bit late, here are some links:

 

Indian Gooseberry (Phyllanthus emblicaL.): Phytochemistry, Pharmacology and Therepeutics

http://www.researchg...77a0a000000.pdf

 

An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda

http://www.ncbi.nlm....les/PMC3252722/

 

Antioxidant Treatment of Tardive Dyskinesia: An Alternative Approach to a Potentially Disabling Side Effect

https://www.utexas.e...ds/02-18-11.pdf

 

Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia.

http://www.ncbi.nlm....pubmed/25866243

 

had some finding with Ginseng and Curcuma as well.

[YoungSchizo]

Well, week three on Latuda, I'm quite positive with it's anti-psychotic MOA, like I already told it works fast, it's a clean drug (compared to 3 other AP's I took) and I remain creative on it. (the last one is positive and negative because being creative is linked to severe mental illnesses, so I have to have my guard up when it comes down to, say paranoia)

 

The downsides are more side-effect related: it can make really drowsy, restless and agitated that can fuck up most of the day. I don't know what I dream or if it is even dream-related but I sweat like a pig during the night. I also experience some sexual-dysfunction but I can't be really clear about it because the cause is maybe partially psychological. The thing I'm happy about is that the Parkinsonism only happened one day and so far I don't see any serious side-effects to drop this drug.

 

Now my question would be, which Nootropics enhance the working of the PFC area? (I know I have asked the same question more often but maybe there are fresh mind reading this and maybe they can help me out). I still have this issue, like on all AP's that my right front area of my brain my brainwaves still are out of wack and causing undesired symptoms that makes me function hardly in daily life and/or around other people. 

[OneScrewLoose]

Just to let you know I responded here.

[treonsverdery]

I read many of the items with appreciation

I hear voices or rather perceive voicelike communications conversations as well as a kind of graphics co processor like effect

 

These are reviews of dumpsterdived antipsychotic pills I found Note that taking one or half of one of these prior to sleeping a few occurences is different than the sustained use that could reduce the somnolence side effects (possibly)

 

The voices that I hear or perceive say that if i i describe them that minimizes their being describing them seems to have an absence of effect on the amount of their perceived presence though although I prefer there be an abscence of paranormal perceived presences.   They also communicate that utilizing a antipsychotic pill removes from their perspective permission to communicate.  There is a near immediate reduction of paranormalist communication as well as graphic coprocessor activity on taking a pill (prior to likely pharmacological effect)

 

haloperidol This causes somnolence taken just prior to sleep it kind of omits lengthy nonoptimal sequence like artificial contexts ("see this, this is your ____ " ,then I zap the thing with a laser, then the voice communicates confusion that I was opposed to what I perceived as nonoptimal action, then it possibly repeats with a slight variation) Sleeping instead makes more sense. One of a half a haloperidol is crummy mostly non effective at my physiochemistry

 

seroquel  an entire seroquel caused all day sleep with noted slight cheerfulness 24 to 72 hours Seroquel is slightly effective

a fifth of a seroquel caused mild ditzy cheerfulness without diminished voices or graphics coprocessor The content of the voices as well as graphics coprocessor may have been perceptipble milder as well as pleasanter

 

prochlorperazine also described as compazine these caused transition to sleep with much less day sleepiness with a noticeable yet mild reduction of voices as well as a noticeable reduction of graphics coprocessor effects I think this is Compazine is slightly effective possibly better than seroquel

 

Different things that have an effect

color has an effect with white or light blue causing greeater well being  Green could just be a kind of different channel or different branch

Earplugs diminish the voices although physics is woithout an explanation

theanine causes sleep, which kind of precludes the mental repractice of (this) (zap) (confusion)which when you think about practicing an idea or thought pattern less practice might be beneficial

 

Now the novel area  I read that 1.2 grams of blended omegas 3 lipid each 24 hours causes a reduction of schizophrenia transitions so i will be seeing if that has any function

 

This reference says 10g of omega 3 lipids each 24 hours http://www.ncbi.nlm..../pubmed/8729113

This reference says 1.2g of omega 3 kipds each 24 hours  http://www.nature.co...pp2011187a.html

this is a popularization with minimal dose data http://articles.merc...izophrenia.aspx

 

 

 

 

 

 

Edited by treonsverdery, 27 October 2015 - 07:35 PM.

[treonsverdery]

Also along with the reviews of antipsychotic pills there are areas that have much less perception of voices or graphic coprocessor effects

public spaces that are comparatively quiet

  libraries

  mall walking

 

either of these reduce perceptual voices or graphics coprocessors possibly 9/10ths or more

 

[Muad'Dib]

I found a Interesting article about epigenetics relevant to schizophrenia  http://www.ncbi.nlm....pubmed/19029285.

 

 

[xxxxxxxx]

{this is for those people that feel a little unmotivated or distrustful and decide to self-diagnose one of the most serious mental disorders; schizophrenia]

y'all need to lay off WebMD sometimes. When you hear hoofbeats, think horses, not zebras. It's probably depression or anxiety.

 

If a person is remotely capable of contemplating whether they have schizophrenia...they really, really, probably don't have schizophrenia. Plenty of disorders share the negative symptoms, but it's a bit hard to accidentally forget about the hearing voices or thinking you're Jesus Christ bits. 

 

Schizophrenia is a degenerative organic brain disease, which sets it apart from most other mental illnesses. True there are degenerative components in, say, depression, but you know what I mean...relative severity.

 

{for those who genuinely have it}

y'all are not going to be cured by drinking the correct herbal tea or vitamin. Best you can hope for is offsetting side effects of the heavy-duty antipsychotics you're on, but even there don't expect miracles. I wish you luck though.  

 

 

Now I sit back, relax, drink my tea, and watch as I'm going to get massively downvoted.

 

 

Edited by MiaouMixe, 05 November 2015 - 03:59 AM.

[YoungSchizo]

{this is for those people that feel a little unmotivated or distrustful and decide to self-diagnose one of the most serious mental disorders; schizophrenia]
y'all need to lay off WebMD sometimes. When you hear hoofbeats, think horses, not zebras. It's probably depression or anxiety.

If a person is remotely capable of contemplating whether they have schizophrenia...they really, really, probably don't have schizophrenia. Plenty of disorders share the negative symptoms, but it's a bit hard to accidentally forget about the hearing voices or thinking you're Jesus Christ bits.

Schizophrenia is a degenerative organic brain disease, which sets it apart from most other mental illnesses. True there are degenerative components in, say, depression, but you know what I mean...relative severity.

{for those who genuinely have it}
y'all are not going to be cured by drinking the correct herbal tea or vitamin. Best you can hope for is offsetting side effects of the heavy-duty antipsychotics you're on, but even there don't expect miracles. I wish you luck though.


Now I sit back, relax, drink my tea, and watch as I'm going to get massively downvoted.

I'm going to downvote you for saying the truth.

[insearchfor]

Schizophrenia is a degenerative organic brain disease, which sets it apart from most other mental illnesses. True there are degenerative components in, say, depression, but you know what I mean...relative severity.

 

That's not really true. Only difference in healthy and schizophrenic brain is the difference in enlargment of brain ventricles. That is nothing degenerative.

[xxxxxxxx]

enlargement of ventricles= shrinking of whole brain. That's a biggie. 

[AlexCanada]

 

 

 

I've been on ZMA (zinc 30mg, magnesium and B6) for years. Can't really say that it negatively or positively effects my symptoms, don't feel much difference on or off it at all. 

 

As for typical antipsychotic, is it worth looking into it? I mean, aren't those much more evil than atypicals when it comes down to dopamine affinity and/or serious side-effects? 

Abilify is like the only anti-psychotic with negligible / minimal side-effects , including neuro-endocrine but it can still cause anxiety for some people...amisulpride is relatively low on side-effects but it is not available in the USA.

Clozapine is sort of safe, but it also has anti-cholinergic effects. Still less side-effects than the majority of anti-psychotics, though. Less dopamine antagonism as well.

 

 

Abilify I've tried in the past but it was to sedating/zombifing. Amulsipride is available here, I've tried to get that but they rejected my wish because the pdoc was not "familiar" with it's MAO. Clozapine I never thought about because of it's possible negative effect on the liver and I don't want to let my blood checked-up every couple weeks/months.

 

What do you think of this one Lurasidone, it's fairly new. The thing that's important for me while picking a "new" (even though they're all crap) anti-psychotic is that I can still be creative and maintain/gain muscle-mass. I'll probably go with Lurasidone, if that doesn't relieve some symptoms I will force them to give my Amulsipride. 

 

I think that Latuda (Lurasidone) has terribly corny commercials, lol. 

As far as it's mechanism of action , it has an even greater affinity for 5-HT7 than risperidone, but also has zero / negligible histamine affinity which means it should produce far less sedation or be void of sedation...it doesn't seem too bad...and the 5-HT7/2A antagonist properties could be very beneficial for bodybuilding as it would result in cortisol reduction.

 

 

 

Does Risperidone reduce cortisol as well? I am hoping for cortisol increase actually as my cortisol levels are extremely low (along w Testosterone, Estrogen, Thyroid) and I feel horribly lifeless all the time. Plus all the negative schizo symptoms.

 

Hoping to try Risperidone again (after 10+ years break) on jan 4th when I see my doctor but Latuda looks promising. Too bad about the cortisol reduction or... does it modulate cortisol in any way? If mine is low would it balance it out or reduce further?

 

What other options are available? I'm in Canada. No amisulpride here. But if anyone has any good pharmacy options my doctor can fax script. 

Edited by AlexCanada, 03 January 2016 - 11:05 AM.

[registered]

whatever ap you choose look to start at minimal dosages and then taper slowly every two weeks or so

i think this aproach by my doctor made me free of side effects

[AlexCanada]

I got 20mg samples of Latuda from my doc today. According to medscape it increases toxicity of valium, gabapentin, ritalin, and cymbalta.

 

Gabapentin I can drop if needed. Ritalin I can limit to super low doses. Cymbalta I can quit if need be but I was hoping to augment cymbalta. I only started taking micro doses around 2-3mg with some subtle benefit and was considering raising it. Valium I am on a slow long withdrawal at 0.5mg a day. And NSI-189 10mg I took for two weeks and last dose was 36 hours ago. Also been taking a SARM LGD 4033 2 drops past few days. 

 

 

Would Latuda be fairly safe with what I am taking?  I can't drop the valium. I can drop most else. The idea is that cymbalta helps w my CFS and helps bring back some functionality while Latuda does whatever it will do to assist my anhedonia, low pleasure, underlying anx from benzo/gaba withdrawal, and cymbalta induced physical anx if I choose to continue cymbalta. When I was up to 20mg+ of cymbalta there was fair bit of physical anxiety.

 

I have negative symptoms of schizophrenia. All of them. None of the positives. Very anhedonic depression w poor physical energy and poor mental energy.

 

 

I plan to cut the tablets and start very low around 2mg and go up from there.  

Edited by AlexCanada, 05 January 2016 - 01:57 AM.

[medievil]

What is mostly helping your anhedonia now? I only found stimulants beneficial.

[XXX XXX]

sleep deprivation can completely remove the negative symptoms - ie, the unsub 24 hours to 48 hours - 18 hours after getting training of the mind, ie talking to people write down their feelings and thoughts on paper - it helps. To sleep deprivation was felt these symptoms should not take neuroleptics

[Galaxyshock]

Chronic Schizophrenia Put Into Remission Without Medication

New research suggests ketogenic diet may play a role in treating schizophrenia.

https://www.psycholo...hout-medication

Edited by Galaxyshock, 05 June 2019 - 01:13 PM.