4 replies to this topic

[Valijon]

I recently purchased some N.A.C. because of all the benefits Of been reading about. However, even a small amount, say 500mg, is making me very aggressive. I'm not a super aggressive person naturally. It's like you turned my irritability factor up five fold.

Is this normal? Anyone else experience this? It appears I'll have to stop taking this Nootropic.

[adamh]

I noticed something similar when I started nac this year. Not everything gets me angry but now when I do get mad it seems out of proportion and tends to linger. I have definitely become more irritable since taking it. Searching the literature, the only place I found a correlation between nac and aggression was a study done on teenagers. It seems to be an outlier reaction so probably only a couple out of a thousand experience it. Due to the many health benefits I don't want to ditch it so I just try not to overreact when something goes wrong

[Galaxyshock]

Does this effect happen soon after ingesting NAC? I could have use for some extra aggression for my workouts, haha. 

[longcity90]

Could it be related to the mobilization of heavy metals? or the androgen receptor? I'm experiencing the same things.

[Galaxyshock]

My guess is its action on the glutamatergic sites (NMDA and metabotropic glutamate). Glutamate is linked to aggression in certain situations. Perhaps you need a GABAergic with it to chill things down if you want to keep taking NAC.