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Zika Can Teach Us How to Target Neural Stem Cells in Vivo

zika nsc neural stem cell target crispr

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#1 resveratrol_guy

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Posted 19 August 2016 - 09:11 PM


It looks like the zika virus preferentially infects neural progenitor cells (NSCs). In adults, the effects of the disease appear no more significant than the flu, but this new proof that NSC infection occurs in adults as well as babies suggests that it might inhibit neurogenesis for an indefinite period of time, perhaps resulting in accelerated cognitive decline.

That's the bad news, but it's also the good news. It seems we now have a crude design for the preferential targetting of NSCs with drugs or CRISPR, coutesy of some as yet unidentified invasive mechanism in zika. I suspect this will turn out to be the equivalent of GP120 in HIV, the "harpoon" which allows it to infect T cells.

 

Might we modify zika to transport handy CRISPR modifications into NSCs, leaving other cell types relatively untouched? This has interesting ramifications for dementia and possibly brain cancer.

Meanwhile, you might want to stock up on DEET...



#2 ceridwen

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Posted 19 August 2016 - 10:12 PM

I read somewhere the mosquitoes hate floral scents even more than DEET

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#3 sativa

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Posted 20 August 2016 - 09:36 PM

I read somewhere the mosquitoes hate floral scents even more than DEET


Citral, limonene - yes please.
Terpenes FTW!

#4 jack black

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Posted 10 September 2016 - 08:24 PM

Bad news indeed for some of us living in south US. Some people are looking for treatments already.

 

 

Candidate Anti-ZIKV Drugs and Considerations for Use in Pregnancy Drug Name Pregnancy Category Other Considerations and Notes Auranofin C Inform women of childbearing potential of the potential risk of therapy during pregnancy. Azathioprine D Contraindicated for use in pregnant women with rheumatoid arthritis. Bortezomib D Women of reproductive potential should avoid becoming pregnant while on therapy. Clofazimine C Some animal studies have failed to reveal evidence of teratogenicity, but studies done at high doses have demonstrated fetotoxicity. There are no controlled data in human pregnancy. Cyclosporine A C Advise of the potential risks if used during pregnancy. Dactinomycin D   Daptomycin B   Deferasirox C   Digoxin C Concentrations with anti-ZIKV activity may be toxic. Fingolimod C A pregnancy registry has been established to collect information about the effect of this drug during pregnancy. Gemcitabine·HCl D   Ivermectin C   Mebendazole C Inform of potential risk to fetus if taken during pregnancy, especially during first trimester. Mefloquine·HCl B   Mercaptopurine Hydrate D   Methoxsalen C Usually given in combination with UV radiation therapy. Micafungin C   Mycophenolate Mofetil D Boxed warning: Use during pregnancy is associated w/ increased risks of 1st trimester pregnancy loss and congenital malformations; counsel females of reproductive potential regarding pregnancy prevention and planning. Mycophenolic Acid D Boxed warning: Use during pregnancy is associated w/ increased risks of pregnancy loss and congenital malformations; counsel females of reproductive potential regarding pregnancy prevention and planning. Palonosetron·HCl B Drug interaction with SSRIs (Sertraline) causing serotonin syndrome. Pyrimethamine C Women of reproductive potential should avoid becoming pregnant while on therapy. Sertraline·HCl C Boxed warning: Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Consider tapering dose during third trimester of pregnancy. Sorafenib Tosylate D Inform that the drug may cause birth defects or fetal loss during pregnancy; instruct both males and females to use effective birth control during treatment and for at least 2 weeks after stopping therapy. Instruct to notify physician if patient becomes pregnant while on therapy.

 

http://www.cell.com/...3128(16)30303-1

 

another study: http://www.nature.co...84.html#results

Unfortunately, Niclosamide not available in USA.

 


Edited by jack black, 10 September 2016 - 08:50 PM.


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#5 fntms

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Posted 12 December 2016 - 12:26 PM

Shockingly my 19w pregnant wife has been found with past a Zika infection (IgG > 1.9), which might have occurred (no symptoms) around the in vitro conception in Thailand...
I have found niclosamide to buy in a EU pharmacy for her (any idea of dosage?) but fear for the fœtus...





Also tagged with one or more of these keywords: zika, nsc, neural, stem, cell, target, crispr

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