It's taken me a long time to figure it out but it's now apparent that pregnenolone has affinity for or some indirect effect on the 5HT2A receptor and that is, among other things, what I am hypersensitive to. Ironically, reduced activity of the NMDA receptor can supposedly increase activity of the 5HT2A receptor. Perhaps it's both excessive and insufficient NMDA activity that can cause activity at this receptor, explaining both schizophrenia and autism (hypofunction and hyperfunction).
Anyway, I'm very sensitive to 5HT2A activation. I don't like inositol, I find that it has paradoxical effects. I've recently discovered that BCAAs, or at least l-leucine, cause insomnia and poor sleep quality, even as little as 100mg or below can do this to me.
I want the benefits of pregnenolone on cognitive health without the psychiatric disturbances from its serotonergic effect.