I took 1000mg (1 gram) of pregnenolone of the Life Extension brand. This is not pregnenolone sulfate but rather the normal pregnenolone which is capable of converting to all the hormones.
Lower dosages have stronger and more plentiful of effects whereas higher dosages bizarrely have much fewer and milder effects. This is probably due to the gaba-a receptor's U shaped curve of effects (so large dosages of allopregnenolone, pregnenolone's main metabolite, may have opposite effects of lower dosages).
The 1000mg (1 gram) I took produced the following:
Mild weakness in muscles
Subtle fatigue
Subtle restlessness
Subtle excessive thinking
Subtle heightened senses (light sharper, more vivid)
(I haven't slept yet so I can't comment yet on whether it affects sleep quality.)
Most of these effects are due to pregnenolone's downstream activation of the 5ht2a receptors so a 5ht2a antagonist should resolve all or most of these.
With 100mg-400mg (0.1-0.4 gram) I usually experience the following:
Prostate enlargement (not caused by conversion to other hormones)
Heightened libido, increased sexual pleasure; can also cause decreased libido.
Resistance to masturbation-induced effeminate feelings (the feelings we all get)
Mild increased feeling of masculinity (estrogen probably)
Excessive fantasizing and daydreaming, on the schizo or autism-level (gaba-a effect).
Relaxation (gaba-a effect)
Irritability (5ht2a receptor)
Mental energy, motivation increase (dopaminergic)
Mild physical and mental fatigue (5ht2a receptor, not a contradiction)
Falling asleep may be easier but sleep quality itself is drastically lowered (5ht2a receptor)
Excessive thoughts (schizo-like, 5ht2a receptor)