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Persistently low pregnenolone level...what should I do?

pregnenolone

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#1 DarkRiver

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Posted 09 July 2017 - 07:37 PM


May 2017

21 ng/dL (one day after I took a 10mg pregnenolone pill)

Reference Range: 22-237 (ng/dL)

 

Feb 2017

<5 ng/dL (I was on testosterone replacement therapy at the time)

Reference Range: 13-208 (ng/dL)

 

Nov 2016

23 ng/dL

Reference Range: 13-208 (ng/dL)

 

I have been suffering from major depressive disorder for over a year...could this condition have anything to my low pregnenolone? Anyone know of any related risks or symptoms?

 

What is the ideal supplementation dosage...the PureE capsules I have are 10 mg each. Thanks.



#2 aconita

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Posted 10 July 2017 - 01:01 AM

With such a low pregnenolone values no wonder your testosterone is low, more fats in your diet might help.

 

What about your cholesterol and triglycerides?

 

Pregnenolone is usually supplemented at about 70mg every second day.

 

Pimples might be the first side effect to show, adjust dosage in order to avoid that, it takes a while since gets stored in fats.

 

Ray Peat forum is a good place to have a look when it comes to pregnenolone, DHEA and progesterone supplements (which might all be worth considering in your case).

 

https://raypeatforum.com/community/

 

 



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#3 PeaceAndProsperity

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Posted 11 July 2017 - 03:49 PM

Uh.. gee.. could it be that you've taken something which shuts down your HTPA axis like you even suggested? I think that's a clue. Otherwise if you had the issue before you did any doping then there is a fault in some part of the feedback loop.



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#4 DarkRiver

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Posted 07 August 2017 - 09:35 PM

When I was on TRT + HCG, both my DHEA and pregnenolone levels crashed.

 

DHEA - Nov. 2016

1099 ng/dL (61 - 1636)

Pregnenolone - Nov. 2016

23 ng/dL (13 - 208)

 

***STARTED TRT + HCG***

 

DHEA - Feb. 2017

255 ng/dL (61 - 1636)

Pregnenolone - Feb. 2017

<5 ng/dL (13 - 208)

 

***STOPPED TRT + HCG***

 

DHEA - May. 2017

414 ng/dL (61 - 1636)

Pregnenolone - May 2017

21 ng/dL (13 - 208)

 

Looks like my DHEA is still trying to recover and get back to 1000+ where it was originally.

 

 

Ray Peat forum is a good place to have a look when it comes to pregnenolone, DHEA and progesterone supplements (which might all be worth considering in your case).

 

https://raypeatforum.com/community/

 

Thanks; I tried it.
 







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