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What to take for life extension? Your top list

life extension niagen supplement research longelivity

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#61 brosci

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Posted 19 January 2019 - 07:09 AM

This is plain wrong, high dose nicotinic acid, sends BG into double numbers for insulin resistant, and diabetic individuals.

Do NMN / NR have this negative effect on BG?



#62 dazed1

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Posted 19 January 2019 - 07:13 AM

Sorry, haven't use them.

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#63 Captain Obvious

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Posted 19 January 2019 - 07:56 AM

In case you didn't already know, IP6 (also known as phytate) is a chelating agent, and is particularly known for absorbing Zinc, but also Manganese, Magnesium, Copper and others. Personally, I wouldn't take it for the long term for that reason, but if you do, then added Zinc supplementation and periodic blood tests (serum Zinc is fine) would be advisable.

 

Yes, in fact I think the main motivation for taking IP6 is the chelation of iron.

I'm getting zinc from the Only Trace Minerals product (20 mg) as well as a half-dose from LEF Two-per-Day multivitamin. I'm also supplementing occasionally with extra zinc and selenium. 

 

Thanks for the suggestion, I will have my zinc levels checked the next time I go for a blood tests. It's a good idea.


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#64 MikeSh

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Posted 16 May 2019 - 05:27 PM

Is anyone taking/has anyone taken dasatinib and quercetin? I'm interested in dosages/protocols.



#65 Daniel Cooper

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Posted 16 May 2019 - 05:39 PM

Is anyone taking/has anyone taken dasatinib and quercetin? I'm interested in dosages/protocols.[/size]

 
 
Instead of asking the same question in multiple threads you might do a google site search like this:
 
Google: dasatinib site:www.longecity.org
 
This is probably one to look at for dosage:
 
Dasatinib group buy from Nyles

Not for the group buy info (which is long over) but for the dosage.

Edited by Daniel Cooper, 16 May 2019 - 05:41 PM.

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#66 APBT

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Posted 16 May 2019 - 05:41 PM

 
 
Instead of asking the same question in multiple threads you might do a google site search like this:
 
Google: dasatinib site:www.longecity.org
 
This is probably one to look at for dosage:
 
Dasatinib group buy from Nyles/

Not for the group buy info (which is long over) but for the dosage.

 

And this:  http://www.longecity...nds-healthspan/


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#67 VP.

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Posted 16 May 2019 - 06:16 PM

Is anyone taking/has anyone taken dasatinib and quercetin? I'm interested in dosages/protocols.

This what Bill Faloon posted at RADDfest in Sept. 2018. See 27:41. 

 

https://www.youtube....h?v=rstf5o9hdUE

 

 


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#68 VP.

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Posted 16 May 2019 - 07:03 PM

Is anyone taking/has anyone taken dasatinib and quercetin? I'm interested in dosages/protocols.

 

This is the best forum I've found for those experimenting with D&Q. Good luck. 

 

https://forum.age-reversal.net/



#69 GABAergic

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Posted 16 May 2019 - 07:19 PM

i basically sum it up in this highly underrated thread; https://www.longecit...ealth-opinions/


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#70 Rossi

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Posted 18 June 2019 - 06:08 PM

Currently daily: 

 

NIAGEN® Nicotinamide Riboside 250 mg

Quercetin (as quercetin dihydrate) 150 mg

Trans-Resveratrol [from Japanese knotweed (root)] 100 mg

Red grape (fruit) and wild blueberry (fruit) blend [providing polyphenols, anthocyanins, OPCs] 40 mg

Fisetin [from wax tree extract (stem)] 10 mg

 

Plus two ibuprofen tablets, 400mg total.


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#71 Ukko

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Posted 18 June 2019 - 06:50 PM

A tough question and one where may answers would vary quite a bit over the years. Let me put it this way, the top 5 things I would want to achieve and what I think can be done to achieve them.

 

1. Increase the NAD+ / NADH Ratio

 

NAD+ precursors such as Niagen (NR), Niacin, Niacin + Ribose combo etc. Certainly no nicotinamide, as it is a moderately toxic NAD+ breakdown product. Also, NAMPT boosters for recycling nicotinamide back to NAD+.

 

Best bang for the buck: Niacin, maybe together with Ribose.

 

2. Increase Glycine / Methionine Ratio

 

Simple ... l-glycine or gelatin. And limiting excessive dairy / meat protein intake

 

Best bang for the buck: l-glycine powder

 

3. Boost the AMPK Axis

 

Bunch of stuff. Gynostemma, lipoic acid, fisetin, berberine etc.

 

Best bang for the buck: lipoic acid, does other useful stuff too

 

4. Block CD38 - Biggest NAD+ Consumer

 

Quercetin, C3G, apigenin etc.

 

Best bang for the buck: quercetin, does other useful stuff too

 

5. Boost H2S

 

Things like MSM, glucosamine and sulporaphane

 

Best bang for the buck: probaby self grown broccoli sprouts, soaked briefly in about 60C water, for the sulporaphane


Edited by Ukko, 18 June 2019 - 06:51 PM.

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#72 Ukko

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Posted 18 June 2019 - 06:52 PM

Currently daily: 

 

NIAGEN® Nicotinamide Riboside 250 mg

Quercetin (as quercetin dihydrate) 150 mg

Trans-Resveratrol [from Japanese knotweed (root)] 100 mg

Red grape (fruit) and wild blueberry (fruit) blend [providing polyphenols, anthocyanins, OPCs] 40 mg

Fisetin [from wax tree extract (stem)] 10 mg

 

Plus two ibuprofen tablets, 400mg total.

 

Like everything else, but what up with Ibuprofen®?
 


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#73 GABAergic

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Posted 18 June 2019 - 08:46 PM

Rossi, do you feel awesome on those things??



#74 Rossi

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Posted 18 June 2019 - 11:06 PM

I do. While ibuprofen does show longevity potential, I use it reduce inflammation and aches. My job is physical but I only work part time (retired), about 20 to 29 hours per week. Oh, one other thing, probably of the most importance, I am vegan. I also use High Intensity Interval Training to maintain bone and muscle. 


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#75 GABAergic

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Posted 19 June 2019 - 07:45 PM

if you are vegan and you consume all those antioxidant supplements, shouldnt that be enough to prevent inflammation and pain?



#76 Rossi

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Posted 20 June 2019 - 01:02 PM

You would think. I think it is all from overuse. Oh and those are not really antioxidant supplements, they are nutraceutical supplements. 



#77 granmasutensil

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Posted 29 June 2019 - 07:27 AM

Calcium disodium EDTA 400-800mg daily(only with multi mineral like albion multi mineral) (sodium edta isn't safe for long term daily use)

Omega 3

Aged garlic extract like kyolic

K2 MK-4

 

TMG

MSM

Astaxanthin

Carnosine

Taurine

Berberine

Vit C 4g+ 2-3 times a day

riboceine (cellgevity/maxone or silymarin/NAC for less effective cheaper option)

NA R-ALA

CoQ10

Succinic Acid

 

Unmodified Potato Starch

psylium husk

 

Considering Centrophenoxine. Stopped sprouting broccoli sprouts, concerned about the amount of DIM androgen receptor blocker it gave. Never included vitamin D/A/B complex at one point it goes from longevity stack OP asked for to just all around health stack. But I guess it would be pretty balanced at that point, would just add a digestive enzyme for every meal and call it a day here. The gut health, unmodified potato starch and psylium made this "longevity stack" over say digestive enzymes because they have more tangible longevity benefits with all the benefits the digestive resistant starch gives for raising buytrate/keeping unwanted bacteria from leaving the gut into internal organs and the psylium fiber for obvious reasons. Maybe add in turnbuckles stem cell renewal protocol, IR sauna use, 15minx3 a week mini trampolene for lymph circulation, and 2-3 day fast with glucosamine+liposomal trehalose one a month as additions.


Edited by granmasutensil, 29 June 2019 - 07:28 AM.


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#78 unbreakable

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Posted 09 July 2019 - 08:36 AM

Only comments I would make are (1) I don't know the point of taking 2 aspirins a week as described above. Probably a better regime is to take a baby aspirin every day.

 

 

For secondary prevention of e.g. myocardial infarction daily baby aspirin makes sense, but for primary prevention in case of low to moderate risk for a heart attack or ischemic insult the risks of bleeding probably outweigh the potential  benefits in that area.

 

If aspirin can also reduce the risk for some cancers or venous thromboembolism the calculation gets more complex.

 

In general I would be a little hesitant combining daily aspirin with a lot of supplements or herbs that influence the bleeding time.

 

Some of the daily aspirin trials for primary prevention seem a bit misleading to me and hard to Interpret. They conclude aspirin prevented x cardiovascular events, but resulted in y "significant bleedings" which required a hospital stay. If y > x -> "aspirin bad". But after a promptly and correctly treated "significant" (non-brain related) bleeding I could leave the hospital healthy again, whereas an infarction usually results in permanent damage.

 

 


Edited by unbreakable, 09 July 2019 - 08:50 AM.






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