8 replies to this topic

[SoundsAboutRight]

Has anyone experienced anxiety/Fear and then a great deal of anger after supplementing with 500mg of Alpha-GPC?

 

Experience after Dosing:

 

1) 5 Minutes - Anxiety/Fear and jumping from objects around me

2) 15 Minutes - Intense Anger

3) 30 Minutes - Continued Anger

 

I have never gotten this type of reaction before and was wondering if anyone might know why this is occurring.

Edited by mfad, 24 July 2017 - 03:22 AM.

[SoundsAboutRight]

Might need to be moved to Mental Health subforum

[Jiminy Glick]

I have never used it but always see people commenting negatively about Alpha-GPC. What were you mad about?

Edited by Jiminy Glick, 24 July 2017 - 05:04 AM.

[Oakman]

All I can say is I've been using 300mg Alpha GPC fairly regularly for a couple months as part of a "Muscles and Endurance" stack. So before  going to the gym, or a 2 hr hike in the mountains, or 30mi biking I take this, I'd say 4-5 times a week.

 

So far I haven't gone 'incredible hulk' on anyone, rather the opposite, I'm in great spirits, have great energy and endurance, low blood pressure and fast recovery. Alpha-GPC is (at least theoretically and among other things like its nootropic effects) good for increased athletic performance and decreased inflammation.

 

Alpha-GPC Caps (300mg)

ActiGin Caps (50mg)

===========

PLUS custom mix  (3 grams)

Alpha Lipoic Acid

L-Carnitine L-Tartrate

CDP Choline

Taurine

MSM

Schisandra chinensis

Rhodiola rosea

D-Phenylalanine

 

I'd suggest reducing the dose to see if you can find a 'sweet spot' for supplementation. Sound as if you are getting over-stimulation from it. Also what other things do you take, and when do you use it specifically might lead you to some answers.  Good luck!

[Benko]

I've been taking 600mg morning and 300 mg afternoon of this recently and though I hadn't put it together my mind has been busier when I meditate and a certain quality during the day.  Difficult to put into words.  Anyway, I could see how it might have that effect i.e. the anger.

 

Perhaps CDP choline supplement might serve your purpose without the anger?

 

 

[gamesguru]

although choline is implicated in mood disorders and PTSD, anything you're feeling at the 5 minute mark can almost certainly be chalked up to the placebo effect

 

not a fan of choline myself, not at all.  not when you take a bunch of other AChEs (ginkgo, tea, bacopa, even common foods you wouldn't suspect, like blueberries^[1]).  then you really have to limit your choline intake from other sources.  i usually don't eat eggs or soy, but still get around 150-250mg of choline

Edited by gamesguru, 25 July 2017 - 08:21 AM.

[SoundsAboutRight]

although choline is implicated in mood disorders and PTSD, anything you're feeling at the 5 minute mark can almost certainly be chalked up to the placebo effect

 

not a fan of choline myself, not at all.  not when you take a bunch of other AChEs (ginkgo, tea, bacopa, even common foods you wouldn't suspect, like blueberries^[1]).  then you really have to limit your choline intake from other sources.  i usually don't eat eggs or soy, but still get around 150-250mg of choline

 

Do you mind going into more detail regarding PTSD/mood disorders and choline. I believe that I remember choline and BPD being an issue in a certain region of the brain though. Was not aware of PTSD.

 

Though, I have taken CDP-Choline and did not feel these types of effects unlike ALPHA-GPC. Does Alpha-GPC target slightly different pathways? This reaction was definitely beyond placebo.

 

Might the Alpha-GPC be hinting at a particular area that might need to be changed - if I can? Maybe continued supplementation even though it makes me extremely anger would be a positive thing? Maybe the effects will even out and something positive will come as a result?

[gamesguru]

GPC and CDP affect the very same pathway, but GPC is actually one step higher on the ladder (closer to the end synthesis, e.g. aceytcholine).  so it affords you, if you will, a wider view of things than does CDP..  sometimes it's the most breath taking views that are the hardest to choke on.

the CDP also generates a uridine molecule which has secondary dopamine effects (even though they may be weak).  you can try a dopaminergic supplement, like shilajit or ginkgo, and see what that does for you.  be careful to back off the choline even more, because both shilajit and ginkgo are AChEs.

in addition to being a lower precursor and having dopamine effects, it's worth mentioning the CDP has a much harder time crossing the blood-brain-barrier and these things together might explain why it doesn't make you as irritable as GPC

 

if you dig deep enough into the literature you'll invariably find ties between each illness and every other neurotransmitter.  you'll resolve yourself into a thoroughly hegelian metaphysic.  these two linked studies are about choline and PTSD, about altered binding in PTSD patients as well as a second study for the permanent stress-induced induction of c-Fos and its negative regulation of the muscarinic loop.  PTSD has a lot in common with BPD, it's a sort of mini-BPD-phreniform disorder if you will.  i would look into glutamate and neurohormones too, you'll find a lot of surprising ties there.  it might explain why green tea (glutamate releaser) doesn't always make me as chill as curcumin (release inhibitor)

http://www.nature.co...s/393373a0.html

https://digital.libr...ndle/2440/56315

 

and i suppose you could continue the GPC and hope for the side effects to just go away, but you do so at your own risk.  i am not recommending it

[kurdishfella]

if u have good memory then you will have more memories that cause u anger and result in  u getting angrier often and like a loop it gets worse and worse unless counteracted with some other memories like logical thoughts? how doing different things improve different parts of the brain? assumptions never work now can you say it in not a doucebag way? can you inject all types of acids