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Rapamycin Survey - How are you using it and what have you noticed?

rapamycin longevity

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72 replies to this topic

Poll: Rapamycin Use Survey (10 member(s) have cast votes)

How long have you been taking Rapamycin

  1. 1 month or less (just started taking it) (3 votes [30.00%])

    Percentage of vote: 30.00%

  2. 2 months (0 votes [0.00%])

    Percentage of vote: 0.00%

  3. 3 months (0 votes [0.00%])

    Percentage of vote: 0.00%

  4. 4 months (1 votes [10.00%])

    Percentage of vote: 10.00%

  5. 5 months (1 votes [10.00%])

    Percentage of vote: 10.00%

  6. 6 months (1 votes [10.00%])

    Percentage of vote: 10.00%

  7. 7-9 months (3 votes [30.00%])

    Percentage of vote: 30.00%

  8. 10-12 months (1 votes [10.00%])

    Percentage of vote: 10.00%

  9. Over a year (0 votes [0.00%])

    Percentage of vote: 0.00%

How often do you take Rapamycin? (Answer approximately if you vary by 1-2 days)

  1. Every day (0 votes [0.00%])

    Percentage of vote: 0.00%

  2. Every other day (0 votes [0.00%])

    Percentage of vote: 0.00%

  3. Every 3 days (0 votes [0.00%])

    Percentage of vote: 0.00%

  4. Every 4 days (0 votes [0.00%])

    Percentage of vote: 0.00%

  5. Every 5 days (1 votes [10.00%])

    Percentage of vote: 10.00%

  6. Every 6 days (0 votes [0.00%])

    Percentage of vote: 0.00%

  7. Weekly (7 votes [70.00%])

    Percentage of vote: 70.00%

  8. Every 8 days (0 votes [0.00%])

    Percentage of vote: 0.00%

  9. Every 9 days (1 votes [10.00%])

    Percentage of vote: 10.00%

  10. Every 10 days (1 votes [10.00%])

    Percentage of vote: 10.00%

  11. Every 11 days (0 votes [0.00%])

    Percentage of vote: 0.00%

  12. Every 12 days (0 votes [0.00%])

    Percentage of vote: 0.00%

  13. Every 13 days (0 votes [0.00%])

    Percentage of vote: 0.00%

  14. Biweekly (0 votes [0.00%])

    Percentage of vote: 0.00%

  15. Every 3 weeks (0 votes [0.00%])

    Percentage of vote: 0.00%

  16. Once a month (0 votes [0.00%])

    Percentage of vote: 0.00%

  17. Every once in a while (0 votes [0.00%])

    Percentage of vote: 0.00%

How much Rapamycin do you take each time (enter the average if vary the dosage)

  1. 1 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

  2. 2 mg (2 votes [20.00%])

    Percentage of vote: 20.00%

  3. 3 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

  4. 4 mg (2 votes [20.00%])

    Percentage of vote: 20.00%

  5. 5 mg (2 votes [20.00%])

    Percentage of vote: 20.00%

  6. 6 mg (3 votes [30.00%])

    Percentage of vote: 30.00%

  7. 7 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

  8. 8 mg (1 votes [10.00%])

    Percentage of vote: 10.00%

  9. 9 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

  10. 10 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

  11. 11-15 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

  12. 16-20 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

  13. More than 20 mg (0 votes [0.00%])

    Percentage of vote: 0.00%

What subjective effects or changes have you noticed that you attribute to Rapamycin

  1. No changes (5 votes [50.00%])

    Percentage of vote: 50.00%

  2. Slight positive changes in stamina or feelings of well-being (2 votes [20.00%])

    Percentage of vote: 20.00%

  3. Medium positive changes in stamina or feelings of well-being (2 votes [20.00%])

    Percentage of vote: 20.00%

  4. Strong positive changes in stamina or feelings of well-being (1 votes [10.00%])

    Percentage of vote: 10.00%

  5. Slight negative changes in stamina or feelings of well-being (0 votes [0.00%])

    Percentage of vote: 0.00%

  6. Medium negative changes in stamina or feelings of well-being (0 votes [0.00%])

    Percentage of vote: 0.00%

  7. Strong negative changes in stamina or feelings of well-being (0 votes [0.00%])

    Percentage of vote: 0.00%

If you have monitored your blood glucose, what changes have you observed

  1. No change (7 votes [70.00%])

    Percentage of vote: 70.00%

  2. Slight increase (less than 5 mg/dl) (0 votes [0.00%])

    Percentage of vote: 0.00%

  3. Medium increase (6-10 mg/dl) (1 votes [10.00%])

    Percentage of vote: 10.00%

  4. Large increase (11+ mg/dl) (0 votes [0.00%])

    Percentage of vote: 0.00%

  5. Slight decrease (less than 5 mg/dl) (2 votes [20.00%])

    Percentage of vote: 20.00%

  6. Medium decrease (6-10 mg/dl) (0 votes [0.00%])

    Percentage of vote: 0.00%

  7. Large decrease (11+ mg/dl) (0 votes [0.00%])

    Percentage of vote: 0.00%

Are you taking Metformin?

  1. Yes (8 votes [80.00%])

    Percentage of vote: 80.00%

  2. No (2 votes [20.00%])

    Percentage of vote: 20.00%

Have you had any blood tests before and after using Rapamycin?

  1. No (5 votes [50.00%])

    Percentage of vote: 50.00%

  2. Yes, and I saw slight positive changes (1 votes [10.00%])

    Percentage of vote: 10.00%

  3. Yes, and I saw medium positive changes (0 votes [0.00%])

    Percentage of vote: 0.00%

  4. Yes and I saw strong positive changes (1 votes [10.00%])

    Percentage of vote: 10.00%

  5. Yes and I saw no changes (2 votes [20.00%])

    Percentage of vote: 20.00%

  6. Yes and I saw slight negative changes (1 votes [10.00%])

    Percentage of vote: 10.00%

  7. Yes and I saw medium negative changes (0 votes [0.00%])

    Percentage of vote: 0.00%

  8. Yes and I saw strong negative changes (0 votes [0.00%])

    Percentage of vote: 0.00%

Have you noticed any side effects that you attribute to Rapamycin?

  1. I have not noticed any side effects (9 votes [90.00%])

    Percentage of vote: 90.00%

  2. mouth sores (1 votes [10.00%])

    Percentage of vote: 10.00%

  3. diarrhea (0 votes [0.00%])

    Percentage of vote: 0.00%

  4. constipation (0 votes [0.00%])

    Percentage of vote: 0.00%

  5. nausea (0 votes [0.00%])

    Percentage of vote: 0.00%

  6. vomiting (0 votes [0.00%])

    Percentage of vote: 0.00%

  7. stomach pain (0 votes [0.00%])

    Percentage of vote: 0.00%

  8. joint pain (0 votes [0.00%])

    Percentage of vote: 0.00%

  9. fast/slow/irregular heartbeat (0 votes [0.00%])

    Percentage of vote: 0.00%

  10. dizziness (0 votes [0.00%])

    Percentage of vote: 0.00%

  11. acne, skin rash (0 votes [0.00%])

    Percentage of vote: 0.00%

  12. headache (0 votes [0.00%])

    Percentage of vote: 0.00%

  13. trouble sleeping (0 votes [0.00%])

    Percentage of vote: 0.00%

  14. muscle pain or cramps (0 votes [0.00%])

    Percentage of vote: 0.00%

  15. bone pain (0 votes [0.00%])

    Percentage of vote: 0.00%

  16. increased thirst or hunger (0 votes [0.00%])

    Percentage of vote: 0.00%

  17. vision changes (0 votes [0.00%])

    Percentage of vote: 0.00%

  18. hearing problems (e.g., hearing loss, ringing in the ears) (0 votes [0.00%])

    Percentage of vote: 0.00%

  19. unusual tiredness or weakness (0 votes [0.00%])

    Percentage of vote: 0.00%

  20. mental/mood changes (0 votes [0.00%])

    Percentage of vote: 0.00%

Do you plan to continue taking Rapamycin?

  1. Yes, forever (5 votes [50.00%])

    Percentage of vote: 50.00%

  2. Yes, for a little whille longer, to see if there are any positive results (2 votes [20.00%])

    Percentage of vote: 20.00%

  3. Maybe / Not sure (2 votes [20.00%])

    Percentage of vote: 20.00%

  4. No (1 votes [10.00%])

    Percentage of vote: 10.00%

Vote Guests cannot vote
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#61 StanG

  • Member
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  • Location:Montgomery County MD
  • NO

Posted 03 January 2018 - 04:04 PM

I have been taking RAPA for 2-3 months now, weekly about 6mg each time. I have not had any sore problems except for a silly mistake I made the first time. However, yesterday I decided to skip this week based on what Dare Devil mentioned to me in an email and I'm glad I did. From now on, I will skip a week every 5 weeks just in case there may be a slow buildup. Maybe that's the way we should all take it.


  • Informative x 1

#62 jbj1

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  • Location:Larkspur, Marin County, Ca.

Posted 04 January 2018 - 09:35 PM

Took 5 mg. Sirolimus once a week for 3 months stopping 3 months ago. No negative effects, possibly increased inclination to exercise. Fasting glucose slightly higher, post-prandial excursion increased slightly, but A1c did not increase. Plan to repeat for 3 months starting next month.
  • Informative x 2

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#63 Michael

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Posted 20 January 2018 - 03:17 AM

Buying a drug from India certainly comes with some risk as well. Biocon appears to be a legitimate company and if dropshipmd really sends that brand maybe you are getting what you have ordered. But there have been problems with pharmaceutical companies from India (and other countries as well):

https://www.consumer...-safe/index.htm

 

India appears to be a particularly risky place to source generic drugs.
 


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#64 smithx

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Posted 19 April 2018 - 06:28 AM

My yearly physical results came back and LDL cholesterol now looks worrisome.

 

Besides rapamycin 2mg every 10 days I've started taking bergamot extract which is supposed to raise HDL while lowering HDL (and my HDL is quite a bit higher).
https://www.ncbi.nlm...pubmed/26779019

I've also been taking nicotinamide riboside 250mg and nicotinamide mono-nucleotide 250mg every other day, which is also supposed to lower cholesterol:
http://www.ctl.corne...tvf12/Sauve.pdf

And also metformin 500mg/d and telmisartan 20mg/d


Measure           2017    2018
=================================
Total Cholesterol 150     234
HDL                39      51
Triglycerides     130     101
LDL-C             117     162
Glucose           106     106

 

 

On my cardiologist's advice, I'm putting rapamycin on hold for a while to see if the LDL goes down, based on studies like this:

 

http://www.jlr.org/c.../43/8/1170.full

 

which indicated that rapamycin can increase cholesterol. That study also indicated that it increased triglycerides however, and mine have gone down. So we'll see what happens.

 

 

 


Edited by smithx, 19 April 2018 - 06:29 AM.

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#65 aribadabar

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Posted 20 April 2018 - 03:14 AM

At this low dosage I don't believe Rapa is the culprit. Something else is at play.



#66 tintinet

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Posted 20 April 2018 - 10:40 PM

My cholesterol levels pre and post rapa are similar- no significant changes.



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#67 tintinet

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Posted 27 April 2018 - 06:32 PM

Labs 2/18

Glucose 92.0 mg/dl

Low Risk HDL (High Density Lipoprotein) 81 mg/dl

Low Risk LDL (Low Density Lipoprotein) 61 mg/dl

Low Risk Total Cholesterol (TC) 162 mg/dl

Low Risk Triglycerides 101 mg/dlGlucose 92.0 mg/dl

Edited by tintinet, 27 April 2018 - 06:32 PM.

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#68 PAMPAGUY

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Posted 20 May 2018 - 07:36 AM

DOB:  7-26-46  Male, 177 lbs., 71", Rapamycin 6 mg. once weekly for 16 months, (no side effects) Metformin 1000 mg. daily, N+R 1.5 gm of each + 15 gm Stearic Acid twice weekly, 5 mg Statin, Crestor daily. (will stop in 3 more months and get another lipid profile) BP 110-120/65-75. (measure daily)  Resting heart rate (52-56).  B/P and Cholesterol have dropped as I have lost weight.  No longer take B/P medication.  Have lost 20 lbs last 12 months.  Believe the combination of Rapa and Metformin helped.

 

Lab results 4-23-18: TC 130, LDL 74, HDL 43, Trigliceride 85,  Creatinine .5, GFR 108, Glucose 100, HbA1c 5.5 from 6.4 9 months ago. CBC within normal limits.

 

Had an arthritic rt. hip, no longer.  Can walk for many miles without any pain. Believe the rapa stops or slows down the arthritis deterioration. 

 


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#69 smithx

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Posted 17 October 2018 - 12:38 AM

Does anyone notice any sleepiness or lethargy on rapamycin?

 

I stopped taking it for a week and felt more awake (I thought) and took a dose today and feel sleepy. Could very well be a coincidence, but wondering if anyone else noticed something similar.

 

 


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#70 QuestforLife

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Posted 17 October 2018 - 11:46 AM

Does anyone notice any sleepiness or lethargy on rapamycin?

 

I stopped taking it for a week and felt more awake (I thought) and took a dose today and feel sleepy. Could very well be a coincidence, but wondering if anyone else noticed something similar.

 

In a word, yes.

 

Peak tiredness for me is normally on the 3rd day with weekly dosing, although recently this has changed and I'm experiencing this earlier. This might be because I've dropped back to a monthly dose; maybe this us something you get used to with weekly dosing, or maybe it is because the rest of my supplement regime has changed.


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#71 MikeDC

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Posted 19 October 2018 - 01:57 PM

I was taking 5mg of rapamycin once a week, then cut back to every 10 days after 8 o r 9 months - total duration almost 11 months. I got a few mouth sores, my wife, who was also taking it, had frequent mouth sores and stopped around 3 months ago. 4 weeks ago I took a 5mg dose. The next day I was out in busy close company. I came down with some kind of flu the following day, and felt sick for 2 weeks. I have discontinued rapamycin for now. I have read that rapamycin may need not only to be taken intermittently, but for only a certain length of time. In the case of the middle aged mice, they were dosed for only 3 months I believe, and yet gained in health and l lifespan. Also,
if the half life of rapamycin is 60 hours, over an extended period there will be a slight build up of itinq the body, a very small and slow build up, but still some. I also want to add that we also take resveratrol, curcumin (not within a day or two of taking rapamycin) and NR, so it is not clear whether any of these other compounds also knock down mtor, and whether there is an net increase in effect.


NR will down regulate mTORC1.
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#72 Razor444

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Posted 20 October 2018 - 10:34 AM

Does anyone notice any sleepiness or lethargy on rapamycin?

 

The opposite. Bigly.

 

I do have an autoimmune disorder, though.



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#73 mkutsen

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Posted 14 July 2019 - 11:09 PM

Everolimus is the less toxic rapamycin analogue that binds the mTORC1 much more selectively.

https://www.ncbi.nlm...les/PMC4717280/

Anyone experimenting with everolimus instead?







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