Given that neuroinflammation, HPA axis dysregulation, insulin receptor deficits, glutamate dysfunction, NMDA receptor dysfunction, GABA receptor dysregulation, oxidative stress, monoamine dysregulations all interact somehow in the pathophysiology of bipolar disorder (and other psychiatric illnesses), I'd like to ask what you think of using the following substances together (or subsequently):
Galantamine (inflammation)
Ibudilast (inflammation)
Intranasal insulin (inflammation, oxidative stress, insulin receptor deficits)
Mifepristone (HPA axis)
Lithium (GABA, glutamate & NMDA, monoamines, inflammation, oxidative stress)
Uridine (already using together with co-factors).
With the first four I don't really know how long I should be taking them to get "back to baseline". Lithium and uridine I'm prepared to take long-term.
With mifepristone I'm not quite sure which vendors are trustworthy; there's a selection of vendors here: https://www.ec21.com...fepristone.html
With lithium, I'm considering the intranasal lithium orotate version.
Most importantly though: Should I take them all together? Starting with some and introducing others? How would a schedule look like?
I was thinking of using baclofen some time ago but reconsidered, since it doesn't tackle the root of my problems.
Background: Bipolar depressive, comorbid general & (crippling) social anxiety, anhedonia, mild OCD. I'm 23 and male.
Medication (would taper off): Lamictal 100mg, quetiapine 50mg.