This study mentions all the epigenetic changes that take place in skin and hair with aging.
So it can be used to find supplements (Topical & in-vivo) to counteract these changes!
EG:
"...The interplay of a complex network of several developmental signalling cascades initiated by different growth factors as well as the changes in key niche components generally participate to the stringent regulation of bESC behaviour during hair follicle growth and/or IFE regeneration after severe injuries [13, 15, 22, 71, 93, 102–106]. These pathways include sonic hedgehog (SHH/PTCH/GLI), EGFR, Wnt/β-catenin, Notch, nuclear factor-kappa B (NF-κB), bone morphogenic protein (BMP), BMI-1 and SOX9 transcription factor. Particularly, the activation of Wnt/β-catenin pathway seems to be necessary for the fate specification of bESCs into hair follicular keratinocytes rather IFE keratinocytes during hair growth cycle while Notch signalling may contribute to the maintenance of the hair follicle fate of bESCs..."
One Solution:
"...In the same way, the use of natural polyphenolic compound, resveratol (trans-3, 4′, 5-trihydroxystilbene) found in red wines and diverse plant species such as grapes, peanuts, berries and pines, as a skin care ingredient, has also been shown to induce the anti-inflammatory and antioxidant effects and enhance the sirtuin enzymatic activity [33–37, 216, 217]. More specifically, a topical application of resveratol may reduce cellular ROS levels and prevent the development of cutaneous disorders such as skin hyperplasia and cancers that may be caused by an UVB light exposure and metabolic stress during chronological aging..."
Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies.
http://europepmc.org...4uCWmbImJKGik.0
