Ok so i found a very reliable source for this and will be placing an order for myself next week, anyone interested in chucking can pm me
L
onge
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Advocacy & Research for Unlimited Lifespans
Posted 21 December 2013 - 02:46 PM
Posted 21 December 2013 - 04:25 PM
Posted 21 December 2013 - 04:40 PM
Posted 21 December 2013 - 04:53 PM
Posted 22 December 2013 - 02:14 AM
Just want to let you know that I'm also trying to get this. I think a combination of this and NSI-189 and maybe even Cerebrolysin would be like nectar of the gods. Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often. Effects should be impressive.A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect
http://pubs.acs.org/....1021/jm101206p
when they refer to it's lead they mean 7,8DHF
Posted 22 December 2013 - 12:57 PM
I think you are on the wrong track when you think the effects of such drugs on neurogenesis are directly linked to their antidepressive effect. I believe it's the calcium signalling that matters.Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often.
Posted 22 December 2013 - 01:53 PM
Just want to let you know that I'm also trying to get this. I think a combination of this and NSI-189 and maybe even Cerebrolysin would be like nectar of the gods. Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often. Effects should be impressive.A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect
http://pubs.acs.org/....1021/jm101206p
when they refer to it's lead they mean 7,8DHF
Posted 23 December 2013 - 04:00 AM
I think you are on the wrong track when you think the effects of such drugs on neurogenesis are directly linked to their antidepressive effect. I believe it's the calcium signalling that matters.Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often.
BTW, if someone should run out of money he/she could try butyric acid supplements, which raise BDNF expression in an epigenetic way.
Posted 23 December 2013 - 09:32 AM
Some phospholipases activate PI3K independent from their production of IP3/DAG, and some can even translocate to the nucleus before doing so.The calcium signalling is what regulates gene transcription yeah but mimicing or increasing bdnf takes care of all that upstream from it
Posted 23 December 2013 - 09:45 AM
Posted 21 February 2014 - 06:48 AM
Posted 21 February 2014 - 07:01 AM
Posted 21 February 2014 - 08:03 AM
Posted 21 February 2014 - 04:40 PM
Posted 21 February 2014 - 06:03 PM
Edited by sk_scientific, 21 February 2014 - 06:03 PM.
Posted 22 February 2014 - 10:13 AM
Posted 22 February 2014 - 09:14 PM
From those with whom I've spoken, there wasn't a perceived benefit in semi-acute dosing. But this is merely subjective feedback from few individuals on a short term schedule.
Posted 23 February 2014 - 06:51 AM
oh i think i know who you mean his name starts with n? i would love to have his contact info to compare notes that would be much appreciated SK
From those with whom I've spoken, there wasn't a perceived benefit in semi-acute dosing. But this is merely subjective feedback from few individuals on a short term schedule.
Well.. were these depressed or cognitively impaired people? If they were healthy people, that's not very indicative of its use for ameliorating neuro(psychiatric) issues.
Posted 23 February 2014 - 08:23 AM
Posted 23 February 2014 - 08:53 AM
Edited by sk_scientific, 23 February 2014 - 08:54 AM.
Posted 23 February 2014 - 09:43 AM
Posted 23 February 2014 - 07:52 PM
Posted 27 February 2014 - 10:21 PM
Posted 27 February 2014 - 10:38 PM
Posted 28 February 2014 - 01:22 AM
Posted 07 March 2014 - 08:42 AM
definitely not cured in three days lol but i feel a lot better and it really feels like it is changing my brain for the better
Posted 07 March 2014 - 09:22 PM
Posted 07 March 2014 - 11:57 PM
Yes, the positive effects have persisted so far, i tried not taking it yesterday and didn't feel great all day and i had trouble sleeping last night.Been feeling better toda since i took it, I have noticed a metalic taste in my mouth lately i dunno if that's related in some way or not.
Posted 08 March 2014 - 03:53 PM
Posted 08 March 2014 - 05:01 PM
Edited by formergenius, 08 March 2014 - 05:01 PM.
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