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Nicotinamide Mononucleotide (NMN) personal experience thread

nmn nicotinamide mononucleotide

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#571 Aak

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Posted 01 November 2019 - 04:20 AM

I’ve been trying to scrool back through to a post on this thread there LawrenceW suggested the optimal dosage per kg of body weight per day but I can’t seem to find it. This thread is huge though, does anyone know the post I’m thinking of?
I’ve been trying to scrool back through to a post on this thread there LawrenceW suggested the optimal dosage per kg of body weight per day but I can’t seem to find it. This thread is huge though, does anyone know the post I’m thinking of?

#572 bluemoon

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Posted 01 November 2019 - 05:10 PM

I’ve been trying to scrool back through to a post on this thread there LawrenceW suggested the optimal dosage per kg of body weight per day but I can’t seem to find it. This thread is huge though, does anyone know the post I’m thinking of? 

 

I don't think anyone knows but in 2007 David Sinclair said he was taking 320 mg of resveratrol a day that corresponded to 5 mg/day/kg so he was 64 kg then. He seems about the same size as then so at 65 kg to 70 kg, Sinclair later took 500 mg of NMN a day for 2 or 3 years and last year said he started to take 1,000 mg a day. Sinclair also said three years ago that his father, who looks about the same weight, has been taking 500 mg of NMN a day.



#573 The Beauty of Peace

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Posted 01 November 2019 - 05:18 PM

The ALIVE by NATURE company changed its NMN powder, not it contains mannitol and other crap. Can anyone recommend another seller?



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#574 aribadabar

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Posted 01 November 2019 - 06:32 PM

The ALIVE by NATURE company changed its NMN powder, not it contains mannitol and other crap. Can anyone recommend another seller?


FWIW this one seems additives-free and reasonably well regarded:
https://www.amazon.c...g/dp/B07N7TKQXZ

#575 LawrenceW

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Posted 01 November 2019 - 07:35 PM

My involvement with NMN began in March 2014 when I assembled a group-buy of 7 males, aged 45 to 69, to begin an 8-month test program of NMN supplementation.  Since that time, that group has grown to over 100 male and female, friends and family. We have tested doses ranging from 40 mgs to 7,200 mgs per day. We have tested capsule, pill, sublingual, and liquid delivery methods of NMN. We have tested single daily dosing to 8-times-per-day dosing. As success parameters we have tracked objective improvements in blood biomarkers. We discovered very early on that the efficacy of NMN-only supplementation dropped substantially after the first 2 months, unless other anti-aging pathways were also activated to create a homeostatic balance within the body. We reacted to new discoveries as they were published. Our past 5 years of testing, combined with our reviews of the hundreds of published studies, has led us to conclude that the current iteration of our NMN formulation provides us the best results with objective improvements in a broad range of blood biomarkers and improvement in biological age as measured by www.aging.ai .

 

My personal dosing experimentation is as detailed on the attachment:

 

 

I am currently 215 pounds so my daily dose of 300 mgs works out to 1.4 mgs per pound or 3 mgs per kg. I take each capsule 1 to 2 hours apart, 7 days a week and try to have taken my last capsule by 3 pm so as to not interfere with my sleep.

 

Attached Files


Edited by LawrenceW, 01 November 2019 - 07:42 PM.

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#576 Chrys

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Posted 01 November 2019 - 07:54 PM

It's been a while since I last looked at your regime Lawrence. The last time you were taking NMN sublingually and now oral. Why the switch?

 

Also, in your last entry in the document you posted you say "NMN w/Act/Bio" (under product column). Please elaborate on what activators you are using.

 

Thanks

 

Chrys



#577 LawrenceW

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Posted 01 November 2019 - 11:10 PM

It's been a while since I last looked at your regime Lawrence. The last time you were taking NMN sublingually and now oral. Why the switch?

 

 

I agree with Michael when he posted this from the Sublingual discussion here: https://www.longecit...-and-nmn/page-4

 

able, on 13 Mar 2019 - 08:35 AM, said:snapback.png

There is a lot of research on sublingual delivery of other molecules and it is known what is required for a successful sublingual product, and what a typical absorption rate is.

 
"Yes, and that research would suggest that NMN and NR are poor candidates  ;) . NMN does have a favorable molecular weight (334.22 Da), but it's very hydrophilic, and hydrophilic substances are generally poor candidates for sublingual delivery: they have no ability to cross the mucosal membranes, and while a very small amount may be absorbed instead tend to just dissolve in the saliva and seep down the throat. Instead, good candidates are mildly lipophilic drugs:"

 

My takeaway from my sublingual experimenting was that the feeling that I was getting more from sublingual was actually due to the numerous mini doses of NMN per day and not because of a supposed cross membrane transport. I have found that taking many small doses spread over the day gives you much better results than one large daily dose.

 

I prefer the capsules as it is much easier and also gives me much better control over the weight of each dose.



#578 Andey

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Posted 02 November 2019 - 03:37 PM

I am currently 215 pounds so my daily dose of 300 mgs works out to 1.4 mgs per pound or 3 mgs per kg. I take each capsule 1 to 2 hours apart, 7 days a week and try to have taken my last capsule by 3 pm so as to not interfere with my sleep.

 

  Thank you.

 Can you share what Bio means in "NMN w/Act/Bio"?

 I see you score each period, is it purely subjective or do you track some biomarkers than became "Best" with the latest regimen?



#579 aribadabar

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Posted 02 November 2019 - 06:59 PM

I also would like to ask if Act means anything more than a few drops of H2O2 previously mentioned?



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#580 LawrenceW

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Posted 02 November 2019 - 07:39 PM

I also would like to ask if Act means anything more than a few drops of H2O2 previously mentioned?

 

We finally found something to replace the H2O2.


  • Needs references x 1

#581 mikey

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Posted 02 November 2019 - 07:48 PM

The ALIVE by NATURE company changed its NMN powder, not it contains mannitol and other crap. Can anyone recommend another seller?

 
Please slow down, Beauty. Mannitol isn't "crap." It functionally improves delivery whether sublingual powder or capsules orally.

This page has some references to studies and hyperlinks that should be considered.

 

https://alivebynatur...owder-12-grams/

 

I may continue to employ the NMN/sorbitol powder or seek a larger scale source to save money, because I do see long-term supplementation with NMN.

 

REFERENCES:

  1. Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies. (Jaipal, 2014)
  2. The Effect of Different Concentrations of Mannitol in Solution on Small Intestinal Transit: Implications for Drug Absorption(Adkin, 1995)
  3. IMPROVEMENT OF DISSOLUTION RATE OF VALSARTAN BY SOLID DISPERSION SYSTEM USING D(−) MANNITOL
  4. Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers
  5. ENHANCEMENT OF CELECOXIB SOLUBILITY BY SOLID DISPERSON USING MANNITOL

This reminds of the nonsensical "scary"  pseudo-science attacks against magnesium stearate. Must be natural for humans to commonly think that chemistry might be a scary demon, when it's just chemistry. 

There's a fully referenced article about it in this link.
https://agereversaln...et-flow-agents/

 

Note that multiple credibly referenced articles by others are viewable at the end of the article.

 

Also, the mention of d-mannitol as being useful in sublingual delivery in A clinical perspective on mucoadhesive buccal drug delivery systems

 

Kind regards.

Mikey


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#582 LawrenceW

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Posted 02 November 2019 - 07:50 PM

  Thank you.

 Can you share what Bio means in "NMN w/Act/Bio"?

 I see you score each period, is it purely subjective or do you track some biomarkers than became "Best" with the latest regimen?

 

 

Bio is short for bio availability.

 

I have been taking NMN for so long now that I can feel subjectively when things are better or worse than the previous iteration.  Now that I have locked in on a formulation, I am going to take it for 3 months and then get a blood test to see if the bio-markers line up with the subjective feeling.

 

"Best" is that I that I believe that I have completed my quest for finding what I believe to be the balance between the lowest dose and the best results.  


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#583 p75213

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Posted 04 November 2019 - 11:04 AM

We finally found something to replace the H2O2.

Would this replace H2O2https://alivebynatur.../nad-energizer/

or how about Suforaphane?


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#584 LawrenceW

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Posted 04 November 2019 - 03:31 PM

Would this replace H2O2https://alivebynatur.../nad-energizer/

or how about Suforaphane?

 

 

Don't know.  They would have to have some people take it and see if the results show up in the bloodwork.



#585 LawrenceW

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Posted 04 November 2019 - 05:39 PM

We finally found something to replace the H2O2.

 

 

bookmark.png Needs references x 1

 

 

Sorry no references other than the anecdotal feedback from the +100 members of our group buy.  If you would like to experience it for yourself and then report back to this forum, please feel free to PM me to join our group.



#586 Dstein

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Posted 10 November 2019 - 04:27 PM

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

single-arm non-randomized intervention was conducted by single oraladministration of 100, 250, and 500 mg NMN.

 

The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature. Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, andblood glucose levels within the normal ranges, independent of the dose of NMN. Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention. Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration.


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#587 p75213

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Posted 12 November 2019 - 12:49 PM

My involvement with NMN began in March 2014 when I assembled a group-buy of 7 males, aged 45 to 69, to begin an 8-month test program of NMN supplementation. Since that time, that group has grown to over 100 male and female, friends and family. We have tested doses ranging from 40 mgs to 7,200 mgs per day. We have tested capsule, pill, sublingual, and liquid delivery methods of NMN. We have tested single daily dosing to 8-times-per-day dosing. As success parameters we have tracked objective improvements in blood biomarkers. We discovered very early on that the efficacy of NMN-only supplementation dropped substantially after the first 2 months, unless other anti-aging pathways were also activated to create a homeostatic balance within the body. We reacted to new discoveries as they were published. Our past 5 years of testing, combined with our reviews of the hundreds of published studies, has led us to conclude that the current iteration of our NMN formulation provides us the best results with objective improvements in a broad range of blood biomarkers and improvement in biological age as measured by www.aging.ai .

My personal dosing experimentation is as detailed on the attachment:


I am currently 215 pounds so my daily dose of 300 mgs works out to 1.4 mgs per pound or 3 mgs per kg. I take each capsule 1 to 2 hours apart, 7 days a week and try to have taken my last capsule by 3 pm so as to not interfere with my sleep.


If your taking such low doses could you just take niacin and not get the niacin flush?

#588 Fredrik

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Posted 12 November 2019 - 01:05 PM

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

single-arm non-randomized intervention was conducted by single oraladministration of 100, 250, and 500 mg NMN.

 

The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature. Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, andblood glucose levels within the normal ranges, independent of the dose of NMN. Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention. Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration.

 

In the personal experience thread?

 

This NMN study is discussed and linked to in this thread:

 

https://www.longecit...ublished-study/


Edited by Fredrik, 12 November 2019 - 01:07 PM.

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#589 Harkijn

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Posted 12 November 2019 - 06:12 PM

NMN users wondering why this first very meagre human trial only comes now and want  to  hear more, might be interested to take a look at this guy's plans. For personal experience we might learn  from his practical endeavours:

https://www.youtube....h?v=AQbDuWcFLJg


Edited by Harkijn, 12 November 2019 - 06:14 PM.






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