2642 replies to this topic

[kurt9]

I've largely answered my own question here. I am using both Cantrophenoxine (Lipofuscin removal) and Rosmarinic Acid (an attempt at AGE crosslink removal) for 2 months PRIOR, then waiting an additional month before doing this stem cell/senolytic protocol. That way I separate them out so that the two do not interfere with each other and potentially cause problems. I'll see what happens.

 

Would it be reasonable to say that the stem cell/senolytic protocol can aid in or be a form of ECM turnover process? Given that every cell in our bodies come from a stem cell and that this would presumably include the fibroblasts, that renewing one's fibroblasts ought to assist in ECM turnover, thus helping to reduce or eliminate AGE crosslinks.

[Kelvin]

I've largely answered my own question here. I am using both Cantrophenoxine (Lipofuscin removal) and Rosmarinic Acid (an attempt at AGE crosslink removal) for 2 months PRIOR, then waiting an additional month before doing this stem cell/senolytic protocol. That way I separate them out so that the two do not interfere with each other and potentially cause problems. I'll see what happens.

 

Would it be reasonable to say that the stem cell/senolytic protocol can aid in or be a form of ECM turnover process? Given that every cell in our bodies come from a stem cell and that this would presumably include the fibroblasts, that renewing one's fibroblasts ought to assist in ECM turnover, thus helping to reduce or eliminate AGE crosslinks.

 

I've not seen anything that can improve the extracellular matrix besides the elastin precursor, tropoelastin.  But tropoelastin is mainly applied to the skin and wouldn't help the ECM across the entire body.

 

Good information on rosmarinic acid.

 

You can also use NMN periodically (probably with the old mito protocol, or NMN by itself) to reduce AGEs since it is a proven AGEs reducing agent.

[Kelvin]

Interesting. What other effects did you notice from the C60 protocol? 

 

Reduced need for sleep.

 

Prior to using C60 I went from not being rested after 8.5 hours of sleep to being able to get by with just 6 hours, even finding it difficult to sleep longer than 6.5 hours unless I had been sleep deprived for a number of days in a row.

Edited by Kelvin, 21 February 2026 - 08:48 PM.