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Anyone considering supplementing with Urolithin A?

urolithin a gordonibacter urolithinfaciens ellagic acid atherosclerosis

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#1 Daniel Cooper

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Posted 03 July 2018 - 05:01 PM


For it's anti-atherosclerosis effect?

 

I don't see anyone selling it as a supplement yet, but I have see Urolithin A powder up for sale on Amazon on occasion (unfortunately don't see any now).

 

Ideally what I'd really like to supplement with is the proper strain of gordonibacter urolithinfaciens then consume ellagic acid, but I can find no once sell a probiotic or even the raw bacterial strain.

 

So, anyone thinking about consuming Urolithin A and if so do you have a source and dose in mind?

 

 

 

 



#2 Oakman

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Posted 04 July 2018 - 03:14 AM

I've just received some Meeker Red Raspberry Powder, so it's raw material for making Urolithin A, if your gut can act on it. Perhaps the right raw material encourages natural gordonibactor growth?

 

516Ma-o-37L.jpg



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#3 Daniel Cooper

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Posted 04 July 2018 - 05:06 AM

It would be awesome if someone would sell a probiotic with gordonibacter urolithinfaciens. 

 

I'm frankly shocked that no one has such a product on the market. Barring that, Urolithin A is orally available and could be supplemented directly, and you wouldn't have to wonder if the bacteria actually did it's thing on the raw material.

 

Why is it that half the supplements that I think really might positively impact your health are unobtainable but all sorts of sketchy worthless things are out there in droves?

 

 

 

 

 


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#4 William Sterog

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Posted 04 July 2018 - 12:08 PM

It would be awesome if someone would sell a probiotic with gordonibacter urolithinfaciens.

I'm frankly shocked that no one has such a product on the market. Barring that, Urolithin A is orally available and could be supplemented directly, and you wouldn't have to wonder if the bacteria actually did it's thing on the raw material.

Why is it that half the supplements that I think really might positively impact your health are unobtainable but all sorts of sketchy worthless things are out there in droves?


Care to talk about the supplements that you consider truly effective?

#5 normalizing

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Posted 04 July 2018 - 07:45 PM

how come only specific type of bacteria can make this thing? so how about the generally good bacteria we get from yogurt for example, what do they do with this?


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#6 CHanderson

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Posted 19 September 2018 - 12:45 PM

Anti-aging Effects Of Urolithin A On Replicative Senescent Human Skin Fibroblasts.

https://www.ncbi.nlm...pubmed/30215291

 

Is worth a read.

 


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#7 Daniel Cooper

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Posted 19 September 2018 - 01:39 PM

Anti-aging Effects Of Urolithin A On Replicative Senescent Human Skin Fibroblasts.

https://www.ncbi.nlm...pubmed/30215291

 

Is worth a read.

 

Good info.

 

This is a very interesting compound.

 

If only we had a source for supplemental urolithin A or a gordonibacter urolithinfaciens probiotic.



#8 Nate-2004

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Posted 19 September 2018 - 05:20 PM

If I had the means I'd find some way to isolate this bacteria and synthesize Urolithin A and find some way to isolate it. I don't know what kind of equipment that takes. Probably more than I can afford.



#9 classicstrat

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Posted 24 September 2018 - 07:24 PM

If I had the means I'd find some way to isolate this bacteria and synthesize Urolithin A and find some way to isolate it. I don't know what kind of equipment that takes. Probably more than I can afford.


https://www.nutraing...ite-urolithin-A

#10 Nate-2004

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Posted 24 September 2018 - 11:27 PM

 

Not so simple as just eating pomegranates and hoping you have the *right* gordonibacter species that can produce specifically (and only) the A variety of urolithin. 


Edited by Nate-2004, 24 September 2018 - 11:28 PM.


#11 classicstrat

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Posted 25 September 2018 - 02:15 AM

Not so simple as just eating pomegranates and hoping you have the *right* gordonibacter species that can produce specifically (and only) the A variety of urolithin.


That trial in the link assumes you don't need to, from what I gather.

Amazentis delivered lab produced Urolithin A directly to people with no toxic effects.
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#12 John250

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Posted 10 October 2018 - 11:05 PM

I use the following product but haven’t noticed anything positive or negative.

https://www.amazon.c...n/dp/B076XQM7HP
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#13 normalizing

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Posted 23 October 2018 - 03:29 AM

with all the titanium dioxide in there, you are likely to find mostly negative long term



#14 classicstrat

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Posted 26 October 2018 - 06:40 PM

I use the following product but haven’t noticed anything positive or negative.

https://www.amazon.c...n/dp/B076XQM7HP


That doesn't contain Urolithin A

#15 John250

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Posted 26 October 2018 - 09:23 PM

That doesn't contain Urolithin A


Oops it was Urolithin B.

#16 Jim Morrison

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Posted 30 October 2018 - 06:57 PM

Oops it was Urolithin B.

In the Ryu paper UB also extended lifespan in the worms. "We found that feeding worms from eggs until death with UA, UB, UC or UD at a standard concentration of 50 μM extended lifespan by 45.4, 36.6, 36.0 and 19.0%, respectively, as compared to the vehicle-treated population".  In the paper, they just focused on UA since its the most prevalent EA-derived metabolite observed in humans.

 

https://www.nature.c...rticles/nm.4132


Edited by Jim Morrison, 30 October 2018 - 06:58 PM.

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#17 Daniel Cooper

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Posted 01 November 2018 - 10:49 PM

I have this vague memory of reading that urolithin B not being as good for atherosclerosis and maybe even having some negative impact.  However, I don't seem to find anything to back that up.

 

Am I just mis-remembering?

 

Also, has anyone found a source for urolithin A?

 

 







Also tagged with one or more of these keywords: urolithin a, gordonibacter urolithinfaciens, ellagic acid, atherosclerosis

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