• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 1 votes

Anyone considering supplementing with Urolithin A?

urolithin a gordonibacter urolithinfaciens ellagic acid atherosclerosis

  • Please log in to reply
53 replies to this topic
⌛⇒ current fundraiser: B.A.S.E Victor @ OpenCures

#1 Daniel Cooper

  • Member, Moderator
  • 1,431 posts
  • 224
  • Location:USA

Posted 03 July 2018 - 05:01 PM


For it's anti-atherosclerosis effect?

 

I don't see anyone selling it as a supplement yet, but I have see Urolithin A powder up for sale on Amazon on occasion (unfortunately don't see any now).

 

Ideally what I'd really like to supplement with is the proper strain of gordonibacter urolithinfaciens then consume ellagic acid, but I can find no once sell a probiotic or even the raw bacterial strain.

 

So, anyone thinking about consuming Urolithin A and if so do you have a source and dose in mind?

 

 

 

 



#2 Oakman

  • Location:CO

Posted 04 July 2018 - 03:14 AM

I've just received some Meeker Red Raspberry Powder, so it's raw material for making Urolithin A, if your gut can act on it. Perhaps the right raw material encourages natural gordonibactor growth?

 

516Ma-o-37L.jpg



sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#3 Daniel Cooper

  • Topic Starter
  • Member, Moderator
  • 1,431 posts
  • 224
  • Location:USA

Posted 04 July 2018 - 05:06 AM

It would be awesome if someone would sell a probiotic with gordonibacter urolithinfaciens. 

 

I'm frankly shocked that no one has such a product on the market. Barring that, Urolithin A is orally available and could be supplemented directly, and you wouldn't have to wonder if the bacteria actually did it's thing on the raw material.

 

Why is it that half the supplements that I think really might positively impact your health are unobtainable but all sorts of sketchy worthless things are out there in droves?

 

 

 

 

 


  • Good Point x 1
  • Agree x 1

⌛⇒ current fundraiser: B.A.S.E Victor @ OpenCures

#4 William Sterog

  • Guest
  • 475 posts
  • 112
  • Location:Dos Hermanas
  • NO

Posted 04 July 2018 - 12:08 PM

It would be awesome if someone would sell a probiotic with gordonibacter urolithinfaciens.

I'm frankly shocked that no one has such a product on the market. Barring that, Urolithin A is orally available and could be supplemented directly, and you wouldn't have to wonder if the bacteria actually did it's thing on the raw material.

Why is it that half the supplements that I think really might positively impact your health are unobtainable but all sorts of sketchy worthless things are out there in droves?


Care to talk about the supplements that you consider truly effective?

#5 normalizing

  • Guest
  • 2,692 posts
  • -95
  • Location:Warm Greetings
  • NO

Posted 04 July 2018 - 07:45 PM

how come only specific type of bacteria can make this thing? so how about the generally good bacteria we get from yogurt for example, what do they do with this?


  • Good Point x 1
  • Informative x 1

#6 CHanderson

  • Guest
  • 4 posts
  • 3
  • Location:Denmark
  • NO

Posted 19 September 2018 - 12:45 PM

Anti-aging Effects Of Urolithin A On Replicative Senescent Human Skin Fibroblasts.

https://www.ncbi.nlm...pubmed/30215291

 

Is worth a read.

 


  • Informative x 1
  • like x 1

#7 Daniel Cooper

  • Topic Starter
  • Member, Moderator
  • 1,431 posts
  • 224
  • Location:USA

Posted 19 September 2018 - 01:39 PM

Anti-aging Effects Of Urolithin A On Replicative Senescent Human Skin Fibroblasts.

https://www.ncbi.nlm...pubmed/30215291

 

Is worth a read.

 

Good info.

 

This is a very interesting compound.

 

If only we had a source for supplemental urolithin A or a gordonibacter urolithinfaciens probiotic.



#8 Nate-2004

  • Guest
  • 2,358 posts
  • 327
  • Location:Philadelphia
  • NO

Posted 19 September 2018 - 05:20 PM

If I had the means I'd find some way to isolate this bacteria and synthesize Urolithin A and find some way to isolate it. I don't know what kind of equipment that takes. Probably more than I can afford.



#9 classicstrat

  • Guest
  • 8 posts
  • 3
  • Location:United States
  • NO

Posted 24 September 2018 - 07:24 PM

If I had the means I'd find some way to isolate this bacteria and synthesize Urolithin A and find some way to isolate it. I don't know what kind of equipment that takes. Probably more than I can afford.


https://www.nutraing...ite-urolithin-A

⌛⇒ current fundraiser: B.A.S.E Victor @ OpenCures

#10 Nate-2004

  • Guest
  • 2,358 posts
  • 327
  • Location:Philadelphia
  • NO

Posted 24 September 2018 - 11:27 PM

 

Not so simple as just eating pomegranates and hoping you have the *right* gordonibacter species that can produce specifically (and only) the A variety of urolithin. 


Edited by Nate-2004, 24 September 2018 - 11:28 PM.


#11 classicstrat

  • Guest
  • 8 posts
  • 3
  • Location:United States
  • NO

Posted 25 September 2018 - 02:15 AM

Not so simple as just eating pomegranates and hoping you have the *right* gordonibacter species that can produce specifically (and only) the A variety of urolithin.


That trial in the link assumes you don't need to, from what I gather.

Amazentis delivered lab produced Urolithin A directly to people with no toxic effects.
  • Informative x 1
  • Agree x 1

#12 John250

  • Guest
  • 1,451 posts
  • 107
  • Location:Temecula
  • NO

Posted 10 October 2018 - 11:05 PM

I use the following product but haven’t noticed anything positive or negative.

https://www.amazon.c...n/dp/B076XQM7HP
  • Informative x 1

#13 normalizing

  • Guest
  • 2,692 posts
  • -95
  • Location:Warm Greetings
  • NO

Posted 23 October 2018 - 03:29 AM

with all the titanium dioxide in there, you are likely to find mostly negative long term


  • Good Point x 1
  • Agree x 1

#14 classicstrat

  • Guest
  • 8 posts
  • 3
  • Location:United States
  • NO

Posted 26 October 2018 - 06:40 PM

I use the following product but haven’t noticed anything positive or negative.

https://www.amazon.c...n/dp/B076XQM7HP


That doesn't contain Urolithin A

#15 John250

  • Guest
  • 1,451 posts
  • 107
  • Location:Temecula
  • NO

Posted 26 October 2018 - 09:23 PM

That doesn't contain Urolithin A


Oops it was Urolithin B.

#16 Jim Morrison

  • Guest
  • 70 posts
  • 5
  • Location:Switzerland

Posted 30 October 2018 - 06:57 PM

Oops it was Urolithin B.

In the Ryu paper UB also extended lifespan in the worms. "We found that feeding worms from eggs until death with UA, UB, UC or UD at a standard concentration of 50 μM extended lifespan by 45.4, 36.6, 36.0 and 19.0%, respectively, as compared to the vehicle-treated population".  In the paper, they just focused on UA since its the most prevalent EA-derived metabolite observed in humans.

 

https://www.nature.c...rticles/nm.4132


Edited by Jim Morrison, 30 October 2018 - 06:58 PM.

  • Good Point x 1
  • Disagree x 1

#17 Daniel Cooper

  • Topic Starter
  • Member, Moderator
  • 1,431 posts
  • 224
  • Location:USA

Posted 01 November 2018 - 10:49 PM

I have this vague memory of reading that urolithin B not being as good for atherosclerosis and maybe even having some negative impact.  However, I don't seem to find anything to back that up.

 

Am I just mis-remembering?

 

Also, has anyone found a source for urolithin A?

 

 


  • Pointless, Timewasting x 1

#18 John250

  • Guest
  • 1,451 posts
  • 107
  • Location:Temecula
  • NO

Posted 20 December 2018 - 11:06 PM

I have this vague memory of reading that urolithin B not being as good for atherosclerosis and maybe even having some negative impact. However, I don't seem to find anything to back that up.

Am I just mis-remembering?

Also, has anyone found a source for urolithin A?


Isn’t urolithin A in pomegranate? Maybe Pomella powder from nootropicsdepot.
  • Needs references x 1

#19 Jim Morrison

  • Guest
  • 70 posts
  • 5
  • Location:Switzerland

Posted 31 December 2018 - 03:06 PM

Isn’t urolithin A in pomegranate? Maybe Pomella powder from nootropicsdepot.

 

Pomegranate contains ellagitannins that are metabolized by the microbiome (of some) to UA. Sadly most of the ellagitannins are in the white parts of the pomegranate. So, IMO, even if you have the right microbiota genotypes consuming the juice will be rather inefficient. May have to go for (hole) fruit powder as suggested, or a smoothie of the entire interior of the fruit :)

 

I haven't found any commercial UA source except analytical standards. We may have to wait for Amazentis to launch their product. AFAIK its in Phase II now for Cachexia.

 

Edit: Link: https://www.amazentis.com/


Edited by Jim Morrison, 31 December 2018 - 03:11 PM.

  • Needs references x 1

#20 Daniel Cooper

  • Topic Starter
  • Member, Moderator
  • 1,431 posts
  • 224
  • Location:USA

Posted 21 January 2019 - 03:11 PM

Pomegranate contains ellagitannins that are metabolized by the microbiome (of some) to UA. Sadly most of the ellagitannins are in the white parts of the pomegranate. So, IMO, even if you have the right microbiota genotypes consuming the juice will be rather inefficient. May have to go for (hole) fruit powder as suggested, or a smoothie of the entire interior of the fruit :)

 

I haven't found any commercial UA source except analytical standards. We may have to wait for Amazentis to launch their product. AFAIK its in Phase II now for Cachexia.

 

Edit: Link: https://www.amazentis.com/

 

 

I assume that Amazentis is going for a prescription drug versus a supplement.  If so, this seems years away.

 

Does anyone have a contact as Amazentis?  I've tried to contact them to no avail.

 

 

 


Edited by Daniel Cooper, 21 January 2019 - 03:12 PM.

  • Informative x 1

#21 GABAergic

  • Guest
  • 349 posts
  • -100
  • Location:Maine

Posted 02 April 2019 - 07:45 PM

my question is, why is there no probiotic with the species Gordonibacter? How do you make sure you have this bacteria otherwise? its likely most of us do not have it

 

anyway, this is in relation to amazentis, it seems Nestle is involved with them now; https://www.nutraing...aging-potential


  • Informative x 1

#22 Daniel Cooper

  • Topic Starter
  • Member, Moderator
  • 1,431 posts
  • 224
  • Location:USA

Posted 04 April 2019 - 08:59 PM

my question is, why is there no probiotic with the species Gordonibacter?

 

 

I've asked this question many times.  If it exists I haven't found it.  

 

I haven't even found a laboratory source of Gordonibacter urolithinfaciens.  



⌛⇒ current fundraiser: B.A.S.E Victor @ OpenCures

#23 GABAergic

  • Guest
  • 349 posts
  • -100
  • Location:Maine

Posted 07 April 2019 - 02:14 AM

so, whats left is to just do a test and see if one has that specific type bacteria then. is there such a test yet? i heard there are already tests to check your microbiome but im not sure if they can do that for all of them. in fact, im not even sure where i read there is a test at all but im certain ive seen it somewhere...


  • Well Written x 1

#24 JPY

  • Member
  • 5 posts
  • 7
  • Location:Germany

Posted 11 April 2019 - 11:28 AM

According to this press release Amazentis is partnering with Nestle and will release Urolithin A as a supplement. Still no indications on the timeline, though. 

 

http://pdf.amazentis...pril_2_2019.pdf


  • Informative x 2
  • Good Point x 2
  • Pointless, Timewasting x 1

#25 Mind

  • Life Member, Moderator, Secretary
  • 16,846 posts
  • 1,999
  • Location:Wausau, WI

Posted 16 June 2019 - 09:37 AM

Maybe Urolithin A contributes to mitophagy and cellular health: https://www.longecit...l-and-cellular/


  • unsure x 1

#26 Daniel Cooper

  • Topic Starter
  • Member, Moderator
  • 1,431 posts
  • 224
  • Location:USA

Posted 16 June 2019 - 05:10 PM

Maybe Urolithin A contributes to mitophagy and cellular health: https://www.longecit...l-and-cellular/

 

I suspect that is the mechanism by which it improves cardiovascular health and decreases age related muscle wasting.

 

Unfortunately Urolithin A seems to be unobtainium at the moment.

 

Amazentis is working on it, but it's unclear to me whether they are developing it as a drug or a supplement.  I reached out to them a couple of years ago but never got a response back.

 

I believe that I have seen a body building supplement in Vitamin Shoppe or someplace similar that purported to contain Urolithin B.  I'm unclear if the B variety carries the same cardiovascular benefits.  But, that does give me some hope that it could potentially be marketed as a supplement as opposed to a drug. 

 

We have a number of specialty supplement makers/retailers (TRL, RevGenetics, Relentless Improvement, etc) here.  I wonder if one of them might be enticed into looking into bringing a Urolithin A supplement to market.


Edited by Daniel Cooper, 16 June 2019 - 05:10 PM.


#27 OP2040

  • Guest
  • 560 posts
  • 112
  • Location:United States
  • NO

Posted 18 September 2019 - 08:48 PM

Also can't wait for this.  Since it seems to be a potentially cheap and effective game-change, it should be ready just in time for our great to the power of 100 grandchildren.  The good news is that I'm primed and ready as my microbiome test shows that I have a whopping .04% of the Gordonibacter  species needed to pump this stuff out.  That sounds low, but it's all relative and it could be a lot for all I know.  To be fair, no one said these are the only species that produce Urolithins, they are just the only ones known so far. 

 

Anyway, I'll get some pomegranate extract and give the little buggers plenty to chow down on



#28 AIP

  • Guest
  • 4 posts
  • 2
  • Location:Saint Louis
  • NO

Posted 24 October 2019 - 01:20 AM

Good discussion. Thanks for all the beta ( rock climbing reference)... this looks promising. Currently I just take a pretty hefty dose of pomegranate extract with a high concentration ( reported ) of ellagic acid so perhaps a small amount metabolizes into urolithin A but if not pomegranate has its upsides and its just part of my stack. 



#29 sedentary

  • Guest
  • 155 posts
  • -14
  • Location:Charlestown

Posted 29 October 2019 - 09:35 PM

Pomegranate contains ellagitannins that are metabolized by the microbiome (of some) to UA. Sadly most of the ellagitannins are in the white parts of the pomegranate. So, IMO, even if you have the right microbiota genotypes consuming the juice will be rather inefficient. May have to go for (hole) fruit powder as suggested, or a smoothie of the entire interior of the fruit :)

 

I haven't found any commercial UA source except analytical standards. We may have to wait for Amazentis to launch their product. AFAIK its in Phase II now for Cachexia.

 

Edit: Link: https://www.amazentis.com/

 

uhm actually the ellagitannins are present in the seeds, some in the white parts but also a lot in the peel which is impossible to consume. but you can chew on the seeds and get some of it. not sure if fruit juices contain any of those parts except the juice surrounding the seeds. but it might contain some of the seed breakdown products just like wine does because i can sense the dryness of tannins on my tongue. perhaps its best to for pomegranate wine since it contains less sugar due to fermentation. its probably healthier versus juice, just in the case of wine vs grape juice.


  • Needs references x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#30 Brundel

  • Guest
  • 22 posts
  • 2
  • Location:US

Posted 01 November 2019 - 01:49 AM

I can make ellagic acid cyclodextrin complex available to you guys probably.
I believe urolithin a is a metabolite.





Also tagged with one or more of these keywords: urolithin a, gordonibacter urolithinfaciens, ellagic acid, atherosclerosis

2 user(s) are reading this topic

0 members, 2 guests, 0 anonymous users