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Anyone considering supplementing with Urolithin A?

urolithin a gordonibacter urolithinfaciens ellagic acid atherosclerosis

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53 replies to this topic
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#31 sedentary

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Posted 01 November 2019 - 02:12 AM

i dunno. what are your qualifications to make one and to be a trusted source?



#32 Brundel

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Posted 01 November 2019 - 02:39 AM

Ive been selling it for a decade. Would just make it available through one of my brands online stores.

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#33 Daniel Cooper

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Posted 01 November 2019 - 11:50 AM

I can make ellagic acid cyclodextrin complex available to you guys probably.
I believe urolithin a is a metabolite.

 

I'm trying to think of a reason we'd want to encapsulate ellagic acid in cyclodextrin.

 

We don't want ellagic acid per se, we want urolithin A.  We want bacteria in the gut to metabolize the ellagic acid into urolithin.  If anything, complexing it with cyclodextrin might interfere with or prevent that process.  Typically you complex things with cyclodextrin when you're trying to protect them to get them through the digestive tract.  That's not what we want at all there. 

 

 


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#34 Brundel

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Posted 01 November 2019 - 04:55 PM

I think I partially agree. I do agree that it may prevent conversion but I disagree that we use cyclodextrins to protect from the gut. Generally we would use a cyclodextrin complex to improve aqueous solubility.
This improves bioavailability not just orally but frequently also intranasal, sublingual, rectal, occular, transdermal etc.

I do think your right though, probably not the best option. I just happened to have some handy.

2 other options then.

A high percentage standardized ellagic acid extract

Synthetic Urolithin a. We can definitely make this but I dont know the costs involved. Might be that unless we wanted a significant volume price would be unreasonable.


Edited by Brundel, 01 November 2019 - 04:55 PM.


#35 Daniel Cooper

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Posted 01 November 2019 - 05:07 PM

I think I partially agree. I do agree that it may prevent conversion but I disagree that we use cyclodextrins to protect from the gut. Generally we would use a cyclodextrin complex to improve aqueous solubility.
This improves bioavailability not just orally but frequently also intranasal, sublingual, rectal, occular, transdermal etc.

I do think your right though, probably not the best option. I just happened to have some handy.

2 other options then.

A high percentage standardized ellagic acid extract

Synthetic Urolithin a. We can definitely make this but I dont know the costs involved. Might be that unless we wanted a significant volume price would be unreasonable.

 

The things I would be most interested in are:

 

1.) Pure Urolithin A.  Either a refined naturally produced product or a synthetic version.

 

2.) A probiotic containing gordonibacter urolithinfaciens which will convert ellagic acid into Urolithin A.

 

At the right price, I'd be more interested in the first option.  But, since this is a supplement you'd want to take more or less continually cost is important.  If I couldn't get Urolithin A at an affordable cost, then option 2 looks better.



#36 Brundel

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Posted 01 November 2019 - 05:20 PM

Hmm, Im not super familiar with gordonibacter urolithinfaciens.

Perhaps we could make both though and create a single product.

If you guys are willing to put the work in Ill see about making it happen. Maybe we can setup a google drive folder and start dumping studies into it.

2 Folders Uro a and Gordon.

 

We would need to make a significant batch of both probably so maybe we can discuss how many people are actually interested.

 

And Finally, maybe Admin or a Mod could contact me so we can discuss the rules and regulations of this forum. I dont want to step on anyones toes or break any forum rules.


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#37 Brundel

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Posted 01 November 2019 - 08:19 PM

When I say both I mean a single product with Ellagic and Gord.

Or synthetic UroA



#38 sedentary

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Posted 01 November 2019 - 10:34 PM

what brand are you selling online?

i appreciate your enthusiasm to get this going as supplement. it will be quiet novel out there as nothing like this exists yet. but i dont see any profit from this. seriously, its not like people out there are waiting for something like this to show up and run and buy it. i would think maybe if you add curcumin, vitamin d, fish oil, cbd and whatever else thats a huge seller as supplement to the mix and viola. we might have something going on here.


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#39 Brundel

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Posted 02 November 2019 - 12:58 AM

Oh I know. I should not have used the term product. Habit.

This isnt for product development but just to give you guys access.

 

I already own an anti aging company that has over a dozen patents including senolytics.

The first will likely be available within 6 months. We are running a bunch of trials to ensure efficacy is where we want it to be.

Within 18 months I suspect we will have 3 to 5 of these products with the goal of 8 for a complete anti aging therapy.

 

This is the product that has ellagic acid in it. Again if there is an issue with me posting things like this let me know and Ill delete and refrain.

The goal isnt to promote the products.

https://www.blacklio...ct-page/rebirth



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#40 sedentary

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Posted 02 November 2019 - 03:05 AM

dont worry about promoting here. this place is mostly children playing with the rating system involving emojis. but, anyway, you still havent shared what company or product you work for? im curious to know now even more because i asked you two times already without much avail :/


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#41 Oakman

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Posted 02 November 2019 - 12:54 PM

dont worry about promoting here. this place is mostly children playing with the rating system involving emojis. but, anyway, you still havent shared what company or product you work for? im curious to know now even more because i asked you two times already without much avail :/

 

His company and the product is in the link. And I don't believe promotion is allowed here, esp. with all the children playing around here ;) . He needs to ask the mods, at a minimum.



#42 Brundel

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Posted 02 November 2019 - 04:29 PM

Definitely need to speak to admin/mod.

#43 karldjack

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Posted 15 December 2019 - 07:12 AM

Late Q1 for Urolithin A when encapsulation issues are resolved
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#44 Daniel Cooper

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Posted 16 December 2019 - 02:56 PM

I'm very interested in your Urolithin A product.  

 

Anything you can tell us about dose and price?

 

 



#45 Daniel Cooper

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Posted 17 December 2019 - 08:32 PM

I can make ellagic acid cyclodextrin complex available to you guys probably.
I believe urolithin a is a metabolite.

 

Urolithin is a product of gut bacteria digesting ellagic acid, if and only if you have the right gut bacteria.

 

Hence the desire to get Urolithin A directly or at least obtain a probiotic with something that will properly digest the ellagic acid, i.e. gordonibacter urolithinfaciens.


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#46 Daniel Cooper

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Posted 30 January 2020 - 08:57 PM

Oh I know. I should not have used the term product. Habit.

This isnt for product development but just to give you guys access.

 

I already own an anti aging company that has over a dozen patents including senolytics.

The first will likely be available within 6 months. We are running a bunch of trials to ensure efficacy is where we want it to be.

Within 18 months I suspect we will have 3 to 5 of these products with the goal of 8 for a complete anti aging therapy.

 

This is the product that has ellagic acid in it. Again if there is an issue with me posting things like this let me know and Ill delete and refrain.

The goal isnt to promote the products.

https://www.blacklio...ct-page/rebirth

 

 

Did you ever introduce your urolithin A product?



#47 ortcloud

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Posted 30 January 2020 - 09:57 PM

Looks like Amazentis decided to make a supplement.

 

"After a decade of research and development, Amazentis is now ready to introduce Timeline. The revolutionary nutrition product is based on the company’s lead ingredient Mitopure which helps to curb age-associated cellular and muscular decline. Timeline will be available in the United States in the first half of 2020."

 

Supposed to be launching in a couple of months

 

https://www.timelinenutrition.com/


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#48 Daniel Cooper

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Posted 31 January 2020 - 07:03 PM

Good info. Let's hope they keep to their schedule.



#49 Brundel

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Posted 31 January 2020 - 07:16 PM

Did you ever introduce your urolithin A product?

 

No sir, current interest doesnt validate the production volume costs.

If you guys are interested I can make available or currently have-

Quercetin niacin co crystals

Tyrosol

BF7

11% salidroside

60% Forskolin

25% chloorogenic acid.

 

Have all of these presently. Most interesting for you guys would likely be the co crystals of quercetin, tyrosol and BF7

Will list on site if you guys can get at least 5x people interested.
 



#50 Brundel

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Posted 31 January 2020 - 08:28 PM

Just gonna put this out there as well.

Within a year there will be a viable set of legit longevity and healthspan solutions available.

If you are on this forum you likely believe lifespan can be increased. We are there.

I wont market or advertise or speak about brands. You will see it happen Im sure but I can tell you for certain that its worth getting excited about. No more trying to patch together solutions from non existing or dubious sources.

No more underdosed products

No more products without efficacy or validity.

Legit patented solutions.


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#51 Daniel Cooper

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Posted 31 January 2020 - 09:14 PM

Just gonna put this out there as well.

Within a year there will be a viable set of legit longevity and healthspan solutions available.

If you are on this forum you likely believe lifespan can be increased. We are there.

I wont market or advertise or speak about brands. You will see it happen Im sure but I can tell you for certain that its worth getting excited about. No more trying to patch together solutions from non existing or dubious sources.

No more underdosed products

No more products without efficacy or validity.

Legit patented solutions.

  

That will be interesting assuming there is data to back up the claims.



#52 William Sterog

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Posted 31 January 2020 - 09:22 PM

No sir, current interest doesnt validate the production volume costs.
If you guys are interested I can make available or currently have-
Quercetin niacin co crystals
Tyrosol
BF7
11% salidroside
60% Forskolin
25% chloorogenic acid.

Have all of these presently. Most interesting for you guys would likely be the co crystals of quercetin, tyrosol and BF7
Will list on site if you guys can get at least 5x people interested.


BF7 as in Brain Factor 7? I am very interested in that.

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#53 Brundel

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Posted 31 January 2020 - 09:48 PM

BF7 as in Brain Factor 7? I am very interested in that.

 

Yup.

Have about 50kg here.

Solo or mixed with

centella

tyrosol

salidroside 11%

caff50mg/cap

 

If for some reason this is against the rules please let me know.



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#54 Brundel

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Posted 31 January 2020 - 10:16 PM

That will be interesting assuming there is data to back up the claims.

 

Indeed.

I think we have the science available today to at least begin combating old age.

My guess is for every 10 years moving forward we should be able to add 10 years to our lifespan.

For now its about cleanup and repair.

maintenance.

 


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Also tagged with one or more of these keywords: urolithin a, gordonibacter urolithinfaciens, ellagic acid, atherosclerosis

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