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Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1

urolithin a nad+ sirt1

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#1 Iporuru

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Posted 25 November 2020 - 10:55 AM



"UA significantly increased ATP and NAD+ levels in mice skeletal muscle (...) Angiogenic markers such as VEGFA and CDH5 which were blunted in skeletal muscles of 28 week old mice were found to be upregulated upon UA supplementation. Such augmentation of skeletal muscle vascularization was found to be bolstered via Silent information regulator 1 (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1α) pathway. Inhibition of SIRT1 by selisistat EX527 blunted UA-induced angiogenic markers in C2C12 cells. Thus this work provides maiden evidence demonstrating that UA supplementation bolsters skeletal muscle ATP and NAD+ levels causing upregulated angiogenic pathways via a SIRT1-PGC-1α pathway (...)


Such increased levels of NAD+ upon UA supplementation was comparable to the effect obtained by supplementing nicotinamide riboside, precursor of NAD+, at a five-fold higher dose"


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