13 replies to this topic

[John250]

Can someone explain this study to me? Is it saying naltrexone Will reduce the high you get from amphetamines or prevent tolerance letting you use less dosing of amphetamines?

https://www.ncbi.nlm...les/PMC5416714/

[gamesguru]

It might lessen tolerance, but only at the cost of dulling the effects.  I wouldn't go taking it expecting adderalls to work like magic, you'll probably just end up feeling restless and a little woozy.  Not a lot of the motivating effects come from glutamate or acetylcholine or something that isn't dopamine.

 

It is worth noting the study is for chronic amphetamine but for the naltrexone it is evidently a single dose response which was investigated.  So it's not right to extrapolate to the general case, or to ask how it will affect me in the daily sense

[metabrain]

I am no expert but this is how it was roughly explained to me. If you take opoids it will upregulate your o1 receptor and give you cravings, Naltrexone will block the o1 receptor and reduce the cravings, but it is dangerous to take with an opoid at the same time, so do not do that. If you take amphetamines long term your dopamine receptor will downregulate, affecting memory. Blockade of o1 will cause some receptors to upregulate in response. So you are blocking the high while also upregulating dopamine.

 

Naltrexone is very unpleasant to take though, I really do not recommend it for general nootropic usage, it will give you the most gut wrenching nausea ever. It should really only be used for the most serious of issues.

[gamesguru]

I am no expert but this is how it was roughly explained to me. If you take opoids it will upregulate your o1 receptor and give you cravings, Naltrexone will block the o1 receptor and reduce the cravings, but it is dangerous to take with an opoid at the same time, so do not do that. If you take amphetamines long term your dopamine receptor will downregulate, affecting memory. Blockade of o1 will cause some receptors to upregulate in response. So you are blocking the high while also upregulating dopamine.

 

In spite of all this fine talk, the remainder of your post will nevertheless reflect how you are elegantly defending the idea of masking one drug's symptoms with another

 

Naltrexone is very unpleasant to take though, I really do not recommend it for general nootropic usage, it will give you the most gut wrenching nausea ever. It should really only be used for the most serious of issues.

Edited by gamesguru, 29 July 2018 - 10:29 AM.

[metabrain]

In spite of all this fine talk, the remainder of your post will nevertheless reflect how you are elegantly defending the idea of masking one drug's symptoms with another

I don't understand what you are getting at, Naltrexone is used to decrease the cravings associated with opoid use, you cannot use naltrexone with opoids. That is what it is prescribed for.

[gamesguru]

I don't understand what you are getting at

 

Just because naltrexone goes well with amphetamine on paper doesn't mean you should rush into the combination in practice.  Two wrongs don't make a right.  You could write a dissertation on how CBD alleviates the negative effects of THC, or you could just go through life sober and be none the wiser

[metabrain]

Just because naltrexone goes well with amphetamine on paper doesn't mean you should rush into the combination in practice.  Two wrongs don't make a right.  You could write a dissertation on how CBD alleviates the negative effects of THC, or you could just go through life sober and be none the wiser

I never said to mix them together, Naltrexone is primarily used as a opoid substitute, the protocol is to withdraw from opoids and then take Naltrexone. The OPs original question anyway was about the research paper which I explained.

[Galaxyshock]

The opioidergic and dopaminergic systems have interesting interactions.

 

Apparently tramadol upregulates nucleus accumbens dopamine receptors D2 and D3 in rats:

https://www.ncbi.nlm...pubmed/15464068

[John250]

The opioidergic and dopaminergic systems have interesting interactions.

Apparently tramadol upregulates nucleus accumbens dopamine receptors D2 and D3 in rats:
https://www.ncbi.nlm...pubmed/15464068

Definitely because I can take a very low-dose Oxy like 2.5-5mg and it prevents my amphetamine cravings

[gamesguru]

Apparently tramadol upregulates nucleus accumbens dopamine receptors D2 and D3 in rats:

https://www.ncbi.nlm...pubmed/15464068

 

 

Send this guy a message if you have any clues.  He ended up taking naltrexone at my advice and getting even worse
 

 

the protocol is to withdraw from opoids

 

that's interesting, because we're talking about amphetamine tolerance not opioid withdrawal

Edited by gamesguru, 30 July 2018 - 11:47 PM.

[normalizing]

i have naltrexone which i never took because i both drink alcohol and take opiates. whats the solution in this case, wait how many hours, like 12 or 24? then not to do any of these and take naltrexone hoping it will make me not crave either and not get sick? i just cant get to taking it thinking it will eventually mix with my other drugs and it will make me sick. im not even sure how long they stay in my system sometimes i dont need them even at 24 hours because they are in my system. its damn difficult to pick time and take fucking nalrexone... there is no damn guide either.

[metabrain]

i have naltrexone which i never took because i both drink alcohol and take opiates. whats the solution in this case, wait how many hours, like 12 or 24? then not to do any of these and take naltrexone hoping it will make me not crave either and not get sick? i just cant get to taking it thinking it will eventually mix with my other drugs and it will make me sick. im not even sure how long they stay in my system sometimes i dont need them even at 24 hours because they are in my system. its damn difficult to pick time and take fucking nalrexone... there is no damn guide either.

I am not sure how long upregulation of the dopamine receptors takes but I would give it many weeks.

 

You cannot drink or mix naltrexone with anything, not even supplements, and that is something I am serious about, naltrexone is a dangerous medication to take, you can easily die from mixing it with opoids or other drugs. You cannot even take pain medication while using it. 

 

The safest thing to do would be to withdraw from alcohol and opoids, make sure they are flushed out of your system, give it at least 10-14 days perhaps more depending on how long you have been on them, and then start Nalrexone. 

 

If you forget and take drugs while you take naltrexone you must immediately go to the ER. (As you risk serious organ damage and death)

 

If you are going to take it I highly recommend you take it under a doctors supervision, the doctor will not judge you for your addiction and can give you better advice than I can.

 

Consider it a medication of last resort and a dangerous one.

 

Here is an information leaflet

https://www.medicine...es/pil.1636.pdf

 

Edited by metabrain, 03 August 2018 - 09:22 PM.

[John250]

I am not sure how long upregulation of the dopamine receptors takes but I would give it many weeks.

You cannot drink or mix naltrexone with anything, not even supplements, and that is something I am serious about, naltrexone is a dangerous medication to take, you can easily die from mixing it with opoids or other drugs. You cannot even take pain medication while using it.

The safest thing to do would be to withdraw from alcohol and opoids, make sure they are flushed out of your system, give it at least 10-14 days perhaps more depending on how long you have been on them, and then start Nalrexone.

If you forget and take drugs while you take naltrexone you must immediately go to the ER. (As you risk serious organ damage and death)

If you are going to take it I highly recommend you take it under a doctors supervision, the doctor will not judge you for your addiction and can give you better advice than I can.

Consider it a medication of last resort and a dangerous one.

Here is an information leaflet
https://www.medicine...es/pil.1636.pdf

But arent benzodiazepines and alcohol the only two drugs you could have a seizure from if you abruptly stop and withdrawl from?

[metabrain]

But arent benzodiazepines and alcohol the only two drugs you could have a seizure from if you abruptly stop and withdrawl from?

The reason why I am saying to stop taking alcohol, opoids and pretty much anything else is polypharmacy.  You don't want to be taking anything with Naltrexone.

 

The recommended amount of time from dropping opoids to taking Naltrexone is 10 days but you could be taking anything so I recommend taking longer.

 

You cannot take shortcuts with this medication.

 

Here is more information http://atforum.com/d.../Naltrexone.pdf place close attention to the safety information.