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Would appreciate any suggestions / advice on my anti-aging regime

mnm nad+ resveratrol metformin omega3 b12 cur cumin tumeric niacin

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#1 RichardAlan

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Posted 08 December 2018 - 05:30 PM


I'm 62, BMI of 22, vegan, Weight 67kg, LDL 98 HDL 55, BP 115/75,  all blood tests within range, no alcohol consumption and no known health problems.  

 

I'm taking some of and planning to move to soon take all of the following and would appreciate advice from the members here:

  • 300mg Niagen (NR)  - morning (Monday to Friday only)
  • Two sublingual 125mg ABN BIO NAD+  - lunch -  (Monday to Friday only)
  • Two sublingual 125mg ABN NMN  - evening -  (Monday to Friday only)
  • Two 250mg Trans-Resveratrol morning 
  • Two 250mg Trans-Resveratrol evening
  • One 500mg Metformin - morning
  • One 500mg Metformin - evening
  • One 5mg Melatonin - evening before sleeping
  • One Omega 3 supplement EPA 700mg DHA 500mg
  • B12 - 400IU
  • D vitamin - 400IU
  • 1/2 multi-vitamin Centrum Silver
  • Curcumin with Bioperine (Tumeric 1350mg)
  • 300mg of niacin

Hoping for some good advice and open to all suggestions to change frequency, dosage, add new or remove some of the drugs.  

 

Thanks

Richard


Edited by RichardAlan, 08 December 2018 - 05:32 PM.


#2 experimenting

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Posted 12 December 2018 - 12:24 PM

I don't have a strong enough knowledge to critique each piece of your stack. What I will say is that if you're otherwise healthy, you're taking a very aggressive approach. Metformin isn't without side effects. 5mg melatonin is a ton considering its a hormone.

Maybe articulate your goals a bit more specifically and create a stack piece by piece?

Edited by experimenting, 12 December 2018 - 12:25 PM.

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#3 Mind

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Posted 12 December 2018 - 08:36 PM

5mg melatonin is more than most people take.

 

Maybe a little IP-6 to chelate heavy metals.

 

You are taking all of the fairly safe things known to slow aging, adding other things would be a little more experimental and a bit more costly

 

Otherwise, exercise, adequate sleep, meditation, and periodic fasting are the non-supplement things that help stay in optimum health.



#4 RichardAlan

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Posted 13 December 2018 - 11:54 AM

5mg melatonin is more than most people take.

 

Maybe a little IP-6 to chelate heavy metals.

 

You are taking all of the fairly safe things known to slow aging, adding other things would be a little more experimental and a bit more costly

 

Otherwise, exercise, adequate sleep, meditation, and periodic fasting are the non-supplement things that help stay in optimum health.

 

Thanks,  You are the second person to comment on the Melatonin so I think it's time for me to reconsider that dosage.  Any suggestions on dosage and do you think it's even helpful for anything related to aging? I started using it as I read in a few places about the aging related benefits but can't be sure how accurate they are. 



#5 Mind

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Posted 13 December 2018 - 04:34 PM

I am not an expert on melatonin. From most rationale that I have read, it is assumed that one should only use approximately 300 mcg of melatonin because that is the average natural increase young people experience when they fall asleep. Whether or not this is a therapeutic dose, something that is effective toward slowing aging is unknown, as far as I am aware. As far as what dose is optimal for slowing aging or preserving health, I don't know. I only know that most people on LongeCity would consider 5mg a little high. Such a dose would be mainly used for helping with sleep.

 

If you feel great on 5mg and don't notice any side effects, then maybe it is okay.

 

I take 1mg almost every night before sleeping, for possible anti-aging effects. 


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#6 John250

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Posted 13 December 2018 - 08:55 PM

TruNiagen
MitoQ
Cycloastragenol
Metformin
Vitality C
D3
EPA/DHA
Na-R-ALA
ALCAR
NAC
7,8 DHF
Lions Mane
CDP Choline
Magnesium
Zinc
Pregnenolone
B-Complex
Selenium
Baby Aspirin
Sublingual S-Acetyl-L-Glutathione
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#7 Mind

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Posted 22 December 2018 - 10:10 PM

Paul Wakfer just informed me that he takes 30mg of melatonin. I think he is getting close to 90 years old. He says he is just fine on this dose. No trouble with sleep/circadian rhythm.

 

There might be some rationale for taking higher doses if you are older. I know some people up their vitamin D3 dose as they get older.


Edited by Mind, 22 December 2018 - 10:11 PM.


#8 Rocket

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Posted 23 December 2018 - 01:28 AM

Isn't resveratrol contraindicated with niacin because of SIRT1? If I was going to take resveratrol, I would take it in liposomal form, else much of it is wasted and not absorbed. Drop niacin altogether.

I would add c60. I have no evidence it works as health prolonging but I have had a positive experience with in after a few weeks of usage.

Also I would take dasatanib on cycles for senescent cell removal.

Finally at 62 I would look into hrt and would take a hgh secretogogue like hex.

Edited by Rocket, 23 December 2018 - 01:29 AM.


#9 John250

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Posted 26 December 2018 - 09:15 PM

Isn't resveratrol contraindicated with niacin because of SIRT1? If I was going to take resveratrol, I would take it in liposomal form, else much of it is wasted and not absorbed. Drop niacin altogether.

I would add c60. I have no evidence it works as health prolonging but I have had a positive experience with in after a few weeks of usage.

Also I would take dasatanib on cycles for senescent cell removal.

Finally at 62 I would look into hrt and would take a hgh secretogogue like hex.


I read pterostilbene and Vitamin C are synergetic with Niagen and I thought resveratrol was the same.

#10 RichardAlan

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Posted 27 December 2018 - 02:51 AM

I read pterostilbene and Vitamin C are synergetic with Niagen and I thought resveratrol was the same.

 

Hi, can you explain what you mean by "synergetic".  Thanks



#11 John250

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Posted 27 December 2018 - 08:38 PM

Hi, can you explain what you mean by "synergetic". Thanks


Meant to say synergistic.

#12 Bubbles

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Posted 09 January 2019 - 02:32 PM

That' is way too little vit. D for you, unless you had tests and all is good. I would up the dose and also add vit. K2 with your D3 so you make sure that the calcium from the blood gets in the right places like bones and teeth and not in your arteries (because D3 increases the concentration of calcium in your blood, and K2 is like a policeman traffic redirector, making sure everything goes to the right place). During winter times I'd recommend 5000ui D3 + K2 (see Bronsons). If you think that is too much, I recommend you read this, The Big Vitamin D Mistake https://www.ncbi.nlm...ubmed/28768407/  "......This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency."

 

Also mantain adequate proper levels of magnesium (get Mg Citrate, great form great absorption) which regulates the Vitamin D3 as well. Besides, D3 is amazing at what it can do to the weird mood some people can have during the winter, slaps depression with a bdsm stick until it goes away a little bit, more or less; really helpful though.


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#13 RichardAlan

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Posted 10 January 2019 - 10:29 AM

That' is way too little vit. D for you, unless you had tests and all is good. I would up the dose and also add vit. K2 with your D3 so you make sure that the calcium from the blood gets in the right places like bones and teeth and not in your arteries (because D3 increases the concentration of calcium in your blood, and K2 is like a policeman traffic redirector, making sure everything goes to the right place). During winter times I'd recommend 5000ui D3 + K2 (see Bronsons). If you think that is too much, I recommend you read this, The Big Vitamin D Mistake https://www.ncbi.nlm...ubmed/28768407/  "......This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency."

 

Also mantain adequate proper levels of magnesium (get Mg Citrate, great form great absorption) which regulates the Vitamin D3 as well. Besides, D3 is amazing at what it can do to the weird mood some people can have during the winter, slaps depression with a bdsm stick until it goes away a little bit, more or less; really helpful though.

 

Thanks and yes I agree with you based on what I read after your comments.  Do you have any suggestions on an amount of K2 and Magnesium? I am already taking a multi-vitamin with Vitamin K 60mcg but perhaps K2 is different and that multi V contains Magnesium 75mg.  



#14 Phoebus

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Posted 22 January 2019 - 07:34 PM

 If you think that is too much, I recommend you read this, The Big Vitamin D Mistake https://www.ncbi.nlm...ubmed/28768407/  "......This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency."

 

 

 

 8000 IU..per day everyday? 

 

Really? Thats seem crazy high to me 



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#15 AceNZ

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Posted 22 January 2019 - 09:10 PM

My two cents:

 

Niagen, NAD+, NMN, Resveratrol -- seems fine

Metformin dose seems high unless you're diabetic. May result in unpleasantly low blood sugar.

Melatonin dose seems high unless you have sleep issues. Usual dose for mild sleep issues is more like 3mg, and for health-only purposes, even 1mg would be fine.

If you're going to take Omega-3 every day, you should include a good, fat-soluble anti-oxidant as well, like Vit E.

Use Methyl-B12. 2000 to 5000 mcg/day is a reasonable dose.

I would suggest taking a B-complex along with your B12. Avoid Folic Acid (Methylfolate is good).

If the niacin is intended to support NAD+, you shouldn't need it with the other things you're taking. B-complex would be better.

Vit D dose is on the low side. Consider switching to 5000IU of D3 per day (I take that much, and skip a dose on days when I get at least 30 minutes in the sun). You may need even more if your blood levels are low.

Consider replacing Centrum Silver with a good multi-mineral, like Pic-Mins.

Curcumin is fine.

 

There's other stuff you might consider adding, but exactly what depends on what your goals and priorities are.

 

 


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