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Naltrexone potentiates Amphetamine Rotational Behavior

naltrexone amphetamine

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3 replies to this topic

#1 John250

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Posted 17 February 2019 - 03:03 AM


http://jpet.aspetjou...ntent/282/2/734

#2 GABAergic

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Posted 17 February 2019 - 05:03 AM

"The role ofmu opioid receptors in these effects remains unclear"

 

thats not the best conclusion to go anywhere with... but anyway does it mean naltrexone use kind of sensitizes the dopamine receptors or what exactly as im confused by this study all together



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#3 John250

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Posted 17 February 2019 - 05:33 PM

"The role ofmu opioid receptors in these effects remains unclear"

thats not the best conclusion to go anywhere with... but anyway does it mean naltrexone use kind of sensitizes the dopamine receptors or what exactly as im confused by this study all together


I didn’t research it enough. I was looking up things that can potentiate the reinforcing affects of Amphetamine and came across that as well as Topamax.

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#4 GABAergic

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Posted 18 February 2019 - 04:18 AM

hmm i thought of topamax as acting on GABA. this is interesting. anyway i wouldnt risk with naltrexone for anything, it is likely to cause dysphoria and other side effects of inhibiting opioid and dopamine system







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