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another supplement to increase NAD+

nad+

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#1 GABAergic

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Posted 15 March 2019 - 05:12 AM


hi i found another supplement that is able to increase NAD+; https://examine.com/...s/oxaloacetate/

 

google oxaloacetate and NAD+ you will see more studies but examine sums it up basically

 

whats the take on this?



#2 Oakman

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Posted 15 March 2019 - 02:02 PM

Another 'somewhat interesting' nutraceutical. I note it is pretty expensive, even among the current and expensive 'longevity' supplements, with 30 100mg capsules ~$50. Reviews are not very enthusiastic. Here is the best explanation that gave a reasonable description of the supplement form Benagene:

 

"The Orphan Drug Act defines "medical food" as a food which is formulated to be consumed or administered under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, as established by medical evaluation.

BenaGene is a medical food, available for the clinical dietary management of the metabolic needs of Glial tumor patients. After review, the US FDA designated Terra Biological's oxaloacetate (CRONaxal) as an "orphan drug" for the treatment of Glial tumors. Although recognized by the FDA as an "orphan drug", CRONaxal is not a drug, but a medical food. Medical foods typically have not undergone the extensive well designed, randomized, placebo controlled trials required for FDA approval as drugs. They are evaluated for safety, and do have a scientific basis for use. Unlike dietary supplements, which do not require medical guidance, and do not specifically address any disease, medical foods must be used under medical supervision and are formulated for a specific disease.

Often, medical foods are used to complement currently available prescription drug therapies. Animal tests indicate that CRONaxal (oxaloacetate) is most effective when combined with chemotherapy, providing a synergistic response to glioma, improving survival over the control group and chemotherapy alone. This increase in survival has not been proven in human clinical trials, but has been seen in some individual case studies. As with all things, individual results will vary. CRONaxal contains oxaloacetate and ascorbic acid (Vitamin C) in easy to swallow veggie capsules. While you have probably heard of Vitamin C, oxaloacetate may be a new term to you. Oxaloacetate already exists in every cell of your body as a natural human compound. It is a critical metabolite in the Krebs Cycle within the mitochondria, providing your body with energy.

Oxaloacetate is also in the food you eat, found in chicken, spinach, apples, potatoes and many other foods, and is used as a dietary supplement in many countries. This medical food provides your body with more oxaloacetate than you would normally consume on a daily basis. Oxaloacetate has been shown to reduce the levels of another metabolite, "glutamate", in the brain in multiple animal studies. Glial tumors are thought by many to spread in part by excreting excess glutamate, which kills surrounding neurons, allowing an area for tumor growth. Oxaloacetate reduces glutamate levels by combining with the glutamate to make the brain protective compound alpha-Ketoglutarate."



#3 GABAergic

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Posted 15 March 2019 - 07:25 PM

yes, expensive. but whatever i read, its always positive concerning oxaloacetate and your post just added more fuel to it. the one thing that im worried is bioavailability from simple capsules. just like most novel compounds out there, oral supplementation is likely not to be much effective. but buying suspicious powders or liquids online and injecting them is insane. so kind of disappointing how difficult it is to obtain so many great things out there because; first no control and proof of quality and quantity in each pill and second difficulty assessing bioavailability if any.



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#4 Phoebus

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Posted 15 March 2019 - 10:53 PM

 

 

As an endogenous molecule, oxaloacetate can sequester glutamate and reduce its activities. This has been shown with injections of oxaloacetate in rats, but due to the high concentrations required it may not be a relevant mechanism for oral supplementation of oxaloacetate (studies using oral oxaloacetate currently do not exist on this topic)

 

so it may not work in humans unless you take very large amounts 



#5 GABAergic

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Posted 16 March 2019 - 01:50 AM

nicotinamide riboside doesnt have good abailability when taken orally and i learned this personally it has no effect. but it hasnt stopped people from buying and using it. im thinking of giving a go on the oxaloacetate. what am i expected to experience? ill report here


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#6 Daniel Cooper

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Posted 19 March 2019 - 01:53 PM

Who says that nicotinamide riboside doesn't have good availability when taken orally?  References?


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#7 GABAergic

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Posted 19 March 2019 - 09:08 PM

https://alivebynatur...amide-riboside/

 

i was reading this



#8 able

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Posted 19 March 2019 - 09:39 PM

Who says that nicotinamide riboside doesn't have good availability when taken orally?  References?

 

 

I think the Liu research is the only one that shows poor bioavailability for oral NR and NMN.

 

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes 



#9 Phoebus

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Posted 19 March 2019 - 10:19 PM

nicotinamide riboside doesnt have good abailability when taken orally and i learned this personally it has no effect. but it hasnt stopped people from buying and using it. im thinking of giving a go on the oxaloacetate. what am i expected to experience? ill report here

 

Yes, if you try it please do report back I would be interested to see how it goes 



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#10 GABAergic

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Posted 02 April 2019 - 07:30 PM

ok i finally started my oxaloacetate. its been only 3 days so its still not conclusive what it does but i gotta say, placebo or not, it definitely does something more than NR ever did for me. I can only compare it to the NR i was taking as caps though, not sure about any other type used sublingual or otherwise. but as i said, its too soon to confirm definately if it helps me in any way or not. i just have been feeling a bit better lately, but i gotta remember i also take dozen of supplements too so it will be hard to know if its just the oxaloacetate doing anything. when i finish the bottle of caps, ill post my final experience. I also have lozenges oxaloacetate which ill start after my bottle of caps finishes and report on that too.


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#11 GABAergic

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Posted 24 April 2019 - 07:43 PM

i finished the sublingual tabs of oxaceatate and i must say one can definitely feel something. but its short lasting. more energy for sure. and what NR never did for me what people say it should, this one actually did it right. except, its short half life. not sure if this thing can help health long term in such way, but so far im more pleased with it than NR and they both go about the same price but people are more willing to spend it on crappy NR.

anyway, im moving to the capsules now. i dont expect same result as sublingual tabs, but we shall see as i report by the end of 2 weeks.


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#12 Harkijn

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Posted 25 April 2019 - 05:28 AM

For some interesting references also see:

https://www.longecit...7-oxaloacetate/


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