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              Advocacy & Research for Unlimited Lifespans


PAYWALLED: Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock ...

aging lifespan proteomics biomarkers longevity healthspan

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#1 Engadin

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Posted 25 April 2020 - 01:45 PM




F U L L    T I T L E : Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock ... and identifies key processes that change with age.



P A Y W A L L E D   S O U R C E :   Aging Research Reviews by Science Direct






  •  32 different human proteomics aging studies were systematically reviewed.
  •  1,128 proteins were found to change with age in two or more different analyses.
  •  Bioinformatics analyses of these proteins heavily implicated inflammatory processes.
  •  A large number of common proteins significantly impact lifespan in animal models.
  •  Commonly identified plasma proteins are able to accurately predict patient age.


The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets. To promote these goals, we performed a systematic review and analysis of human aging and proteomics studies. The systematic review includes 36 different proteomics analyses, each of which identified proteins that significantly changed with age. We discovered 1,128 proteins that had been reported by at least two or more analyses and 32 proteins that had been reported by five or more analyses. Each of these 32 proteins has known connections relevant to aging and age-related disease. GDF15, for example, extends both lifespan and healthspan when overexpressed in mice and is additionally required for the anti-diabetic drug metformin to exert beneficial effects on body weight and energy balance.
Bioinformatic enrichment analyses of our 1,128 commonly identified proteins heavily implicated processes relevant to inflammation, the extracellular matrix, and gene regulation. We additionally propose a novel proteomic aging clock comprised of proteins that were reported to change with age in plasma in three or more different studies. Using a large patient cohort comprised of 3,301 subjects (aged 18–76 years), we demonstrate that this clock is able to accurately predict human age.

Edited by Engadin, 25 April 2020 - 01:46 PM.

Also tagged with one or more of these keywords: aging, lifespan, proteomics, biomarkers, longevity, healthspan

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