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Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice

calorie restriction fasting aging metabolism dietary interventions meal fed time-restricted feeding dietary restriction metabolomics calories

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#1 Engadin

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Posted 02 August 2020 - 08:40 PM


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P A Y W A L L E D   S O U R C E :   Cell Metabolism

 

 

 

 

 

 

Highlights
 
  •  Fasting time linked to CR and meal-feeding confers distinct pro-longevity responses
 
  •  Glycine-serine-threonine metabolism is a key metabolic hub associated with lifespan
 
  •  Short-chain fatty acids and essential PUFA metabolism are unique to healthspan
 
  •  Nonhuman primate serum metabolomics data recapitulate some key features in mice
 
 
 
Summary
 
The impact of chronic caloric restriction (CR) on health and survival is complex with poorly understood underlying molecular mechanisms. A recent study in mice addressing the diets used in nonhuman primate CR studies found that while diet composition did not impact longevity, fasting time and total calorie intake were determinant for increased survival. Here, integrated analysis of physiological and multi-omics data from ad libitum, meal-fed, or CR animals was used to gain insight into pathways associated with improved health and survival.
 
We identified a potential involvement of the glycine-serine-threonine metabolic axis in longevity and related molecular mechanisms. Direct comparison of the different feeding strategies unveiled a pattern of shared pathways of improved health that included short-chain fatty acids and essential PUFA metabolism.
 
These findings were recapitulated in the serum metabolome from nonhuman primates. We propose that the pathways identified might be targeted for their potential role in healthy aging.
 
 
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Edited by Engadin, 02 August 2020 - 08:41 PM.






Also tagged with one or more of these keywords: calorie restriction, fasting, aging, metabolism, dietary interventions, meal fed, time-restricted feeding, dietary restriction, metabolomics, calories

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