• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

Mouse-human drug doses have a 12.6 compensation factor, does mouse time to human time have a compensating factor

mouse time dosage 12.6 compensation factor dose compensation dose compensation factor

  • Please log in to reply
2 replies to this topic

#1 treonsverdery

  • Guest
  • 1,307 posts
  • 160
  • Location:where I am at

Posted 08 August 2020 - 02:08 AM


I read that rodents fed every other day live 30something to 83% longer (online journal references).  The thing is, is there a mouse and rat time compensation factor? The divide by 12.6 for dose compensation factor to find a human dose is based on mouse surface area.  Any ideas what a mouse time compensation factor might be?  Fasting every other day for humans, or perhaps nearly as good, skipping all protein every other day (PR) sounds plausible, but might be less than optimal without a mouse/rat time factor.  At one extreme is lifespan where the compensation factor might be 33 times, less extreme might be mouse sleep periods per 24 hours, another possibility is number of ad libitum meals per 24 hours.

 

Any ideas about what a mouse time compensation factor might be?

 

Write!


Edited by treonsverdery, 08 August 2020 - 02:10 AM.


#2 treonsverdery

  • Topic Starter
  • Guest
  • 1,307 posts
  • 160
  • Location:where I am at

Posted 08 August 2020 - 03:50 AM

https://www.karger.c...Abstract/212538 is the paper where the rodents live 83% longer with intermittent feeding. Any ideas on a mouse/rat time compensation factor?


Edited by treonsverdery, 08 August 2020 - 03:51 AM.


sponsored ad

  • Advert
Click HERE to rent this MEDICINES advertising spot to support LongeCity (this will replace the google ad above).

#3 treonsverdery

  • Topic Starter
  • Guest
  • 1,307 posts
  • 160
  • Location:where I am at

Posted 18 August 2020 - 11:03 PM

I have also wondered about rodent time factor as regards to deprenyl.  Unless I misremember rodents lived 34% longer on three times a week of injected deprenyl, quite a low dose.  But with a rodent time compensation factor that looks, possibly, like 28-66 days between doses of deprenyl at a human, and 24 hours of deprenyl at the peak of AUC for a human, so many minute doses of deprenyl over 24 hours once every 28-65 days to imitate rodent time.  If rodent time exists.

 

One thing that suggests rodent time exists is that mice given phenobarbitol to knock them out for surgery are only out for 10 minutes, but if you gave a human enough phenobarbital to do surgery, a very high dose, I can easily imagine them still asleep 12-24 hours later, sort of suggesting mice metabolize drugs 72 times faster.







Also tagged with one or more of these keywords: mouse, time, dosage, 12.6, compensation, factor, dose compensation, dose compensation factor

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users