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[ta5]

Biomedicines 2025, 13, 2395

Distinctive Gene Expression Profiles and Biological Responses of Skin Fibroblasts to Nicotinamide Mononucleotide: Implications for Longevity Effects on Skin.
Kang, S.; Park, J.; Cho, E.; et al. 

David Sinclair tweeted about this study the other day:

New study of skin finds NMN stands apart from other NAD+ precursors, elevating NAD+ and activating sirtuins, while increasing autophagy, mitochondrial activity & cell growth. 

The heat maps, hierarchical clustering, and PCA showed that NAD+ and NMN triggered a significant biological response, while the other precursors did not. Was in line with other experimental observations that NAM and NR exhibit modest increases in cellular NAD+ levels.

 

 

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[dlewis1453]

Interesting paper, thanks for sharing. We badly need more clarity on the subtle differences in effects of the various nad+ precursors. A simplistic interpretation would be that NMN, being the direct precursor to NAD+, would have the most benefit. We need more studies like this to confirm.