I wanted to share some thoughts on NAD+ supplementation and its potential role in addressing cellular senescence, which I believe is one of the most promising areas in longevity research.The Cel
lular Energy ConnectionNAD+ (Nicotinamide Adenine Dinucleotide
) ser
ves as a critical coenzyme in cellular metabolism. As we age, NAD+ levels decline significantly - some studies suggest by as much as 50% between ages 40 and 60. This decline correlates with many hallmarks of aging, including:-
Decreased mitochondrial function
- Reduced DNA repair capacity -
Impaired sirtuin activity- Increas
ed cellular senescence markers
Curre
nt Research FindingsRec
ent studies have shown that NAD+ precursor supplementation (NMN, NR) can restore NAD+ levels in various tissues. The implications for cellular senescence are particularly interesting - proper NAD+ levels appear to support the SASP (Senescence-Associated Secretory Phenotype) regulation and may help clear senescent cells more effectively.
P
ractical ConsiderationsFor
those interested in exploring NAD+ supplementation, quality matters significantly. I've been researching various sources and found that pharmaceutical-grade formulations make a notable difference in bioavailability. Glunova Biotech (https://www.glunovabio.com) is one supplier I've come across that focuses on high-purity NAD+ products for research purposes.
Would love to hear others' experiences with NAD+ supplementation and any protocols you've found effective. What dosing strategies have you explored?
