Resveratrol extends lifespan in mice and health
#151
Posted 26 December 2006 - 06:35 AM
#152
Posted 26 December 2006 - 09:35 AM
But thanks for your information.
#153
Posted 26 December 2006 - 05:04 PM
Maxwatt: my intake is 240mg Resveratrol (from Country life, 2x100mg Resveratrol and 2x 20mg from Pomeratrol 120mg in the morning and 120mg in the evening) and i have no Problem at all. I am quite happy at this level since that gives me 4.4mg/kg. I'd like to add 37.5mg Resveratrol from the Nautre's Way Product since that has mixed Redwine Polyphenols in it but alas it is not in stock and i just made a large order so ill just wait till my next restock. Till then i'l just have to get by with this low amount. ;-).
But thanks for your information.
Hey curious_sle,
How's that does been treating you? Any short term effects of note? how long have you been doing this?
Your info is considered of value to us members.
I am using Biotest's Rez-V which has 100mg per capsule, supposedly of pure resveratrol (source not given). I use between 50-300mg on various days... trying to notice any immediate differences... maybe some increase in energy of late?
#154
Posted 26 December 2006 - 05:19 PM
So, no ill effects no positive effects thus far.
#155
Posted 26 December 2006 - 05:23 PM
nah no real discernible changes in mood etc but then again i'm a fairly stable person and don't change much. I'll know more about a few baseline parameters in april after my next bloodworks (had a panel before going from good old 20mg :-) to 240 which was like a week ago).
So, no ill effects no positive effects thus far.
Appreciate that... great having people such as yourself doing bloodwork, etc... to guage possible benefits/negatives of supplements. Make sure you post your results and observations in 2007!!
#156
Posted 28 December 2006 - 04:31 AM
With a new picture of a bacterial enzyme in hand, Howard Hughes Medical Institute scientists are now on their way to making “chemical factories” that will help laboratory animals produce their own resveratrol — the compound behind red wine’s frequently touted health benefits.
With Andrew Dillin, they are creating worms that produce resveratrol in the muscle, where it is thought to speed up metabolism. They are engineering mice that produce resveratrol in the muscle, as well, in collaboration with HHMI investigator Ronald M. Evans, also at the Salk Institute. With Leanne Jones, they are producing fruit flies that produce resveratrol in the stem cell niche - a population of cells that is suspected to be involved in regulating longevity. And with Fred H. Gage, they are creating mice that make resveratrol in the neurons in the brain that decline rapidly when struck by neurodegenerative diseases — another potential place resveratrol may exert beneficial effects.
These projects, already underway, are only the beginning of what Noel has planned. Also on the list are animals that produce resveratrol in the liver and special cells in the pancreas that produce insulin. Noel said that by tweaking the ammonia lyase enzyme and other enzymes in the chemical factory in small, targeted ways, his team should be able to genetically engineer animals to produce modified versions of resveratrol. This would give the scientists the opportunity to investigate how a slightly different chemical structure might alter resveratrol’s effects in different tissues.
http://www.webwire.c...l.asp?aId=25569
#157
Posted 28 December 2006 - 07:40 AM
#158
Posted 28 December 2006 - 04:09 PM
#159
Posted 28 December 2006 - 04:34 PM
http://www.webwire.c...l.asp?aId=25569
#160
Posted 29 December 2006 - 04:58 PM
Although my inclination until now has been to ignore your comments regarding our company and our product I am afraid I can no longer restrain my consternation over your innunendos and derogatory conjectures and accusations. If you would have taken the simple courtesy of inquiring of our company before posting your slander we would have been happy to discuss any of the issues you allude to in your postings and present our case to you in a civil and professional manner. In respect to your actual statements, I will make this brief. First, everything set forth or described on the bioflu website is true, accurate and we stand behind it 100%. Second, our product has been challenged before by skeptics with strong credentials and in every instance we have proven our product to be exactly as it is described. We guarantee that Bioforte conforms to the specifications and quality parameters noted on the site and our customers have been more than satisfied to date. Bioflu is owned by Biotivia Neutraceuticals who supplies research grade ingredients to universities, researchers, and formulators. We are no fly-by-night operation as you seem to imply.
#161
Posted 29 December 2006 - 06:49 PM
Bioflu is owned by Biotivia Neutraceuticals who supplies research grade ingredients to universities, researchers, and formulators. We are no fly-by-night operation as you seem to imply.
Could you provide a bit more information about Biotivia? Googling for "Biotivia Neutraceuticals " or "Biotivia Nutraceuticals" returns nothing, and www.biotivia.com is just a junk page parked at GoDaddy. This seems strange for a company that deals with "universities, researchers, and formulators".
On 12/21 you claimed "The product used in this study is called Bioforte". Some assumed you were referring to Sinclair's study, and that you were being dishonest. I find it surprising that you made no effort to clear up this misunderstanding.
As I said in a different thread, I'd really like to find that your product is what you claim it to be. If you could demonstrate this to us, I think you'd likely pick up at least a few customers in the short term, and the positive exposure on this forum would do wonders for your business in the long term.
Establishing your legitimacy will require more than you have provided. Tell us who did the analysis on your product and show us convincing documentation to that effect. Prove your connection to your parent company, and tell us who their customers are. If you have credentials in this industry, let's see them. As the general manager of your company, surely you can find a way to build trust with your potential customers.
#162
Posted 29 December 2006 - 08:24 PM
Maxwatt,
Although my inclination until now has been to ignore your comments regarding our company and our product I am afraid I can no longer restrain my consternation over your innunendos and derogatory conjectures and accusations. If you would have taken the simple courtesy of inquiring of our company before posting your slander we would have been happy to discuss any of the issues you allude to in your postings and present our case to you in a civil and professional manner. In respect to your actual statements, I will make this brief. First, everything set forth or described on the bioflu website is true, accurate and we stand behind it 100%. Second, our product has been challenged before by skeptics with strong credentials and in every instance we have proven our product to be exactly as it is described. We guarantee that Bioforte conforms to the specifications and quality parameters noted on the site and our customers have been more than satisfied to date. Bioflu is owned by Biotivia Neutraceuticals who supplies research grade ingredients to universities, researchers, and formulators. We are no fly-by-night operation as you seem to imply.
Biotivia.com is a parked domain, but there is a page in that domain that points to the bioflu page (below). This is not exactly the sort of thing to inspire confidence, but I am willing to suspend disbelief. I also see that this major supplier to universities, researchers, and formulators is having trouble procuring product:
http://www.bioflu.co...CFSE2OAodbRyJNQ
A google search for biotivia turned up some paid internet advertising and some viral marketing.
NONE-THE-LESS, this could be a cost-effective and useful product for many of us. I could be all-too-willing to overlook your skeezy and contemptuous marketing attempts. (I do hate packing my own pills.) There is just one major problem we have at this point. What is the emodium content of your product? Although there are ways to lower it, a typical 50% resveratrol extract from P. cuspidatum contains 20% emodium. Emodium is a fairly potent cathartic. At this level, the amount of emodium in one of your 500 mg pills would have most people jumping on and off the toilet for 3 days. Outside the commode they would be audibly and fragrantly flatulent. Not a pleasant side-effect.
There are ways to reduce the emodium content, but even at 1 to 3% many people will be uncomfortably "loose." Ten miligrams is too much emodium for some people. Until proven otherwise, I will assume this is a problem with all high-dose resveratrol products on the market. This information should be on the label.
I will stop "maligning" your pills by stating my very valid reservations, if you answer one question: what is the quantative emodium content of your product? Give me a 10 gram sample and I can analyze it for you for about $300*, or have an independant lab do it for about the same price. If you post an image of the analysis on your website, showing the independant labs' letterhead, with name and phone number, no one will have any doubts. It's a worthwhile investment for you.
Anyone can get a Chinese 50% resveratrol extract for about $125 a kilo and pack it into capsules and put them in a bottle with a pretty label; what is critical is the emodium content (among other things.)
*analysis: percentages of trans-resveratrol, cis-resveratrol and emodium by HPLC, heavy metal as lead, bacterial plate count.
Edited by maxwatt, 01 January 2007 - 07:22 AM.
#163
Posted 30 December 2006 - 03:11 AM
Edited by maxwatt, 01 January 2007 - 07:22 AM.
#165
Posted 10 January 2007 - 03:27 PM
http://www.pbs.org/w...ow/3401/01.html
#166
Posted 10 January 2007 - 03:55 PM
#167
Posted 10 January 2007 - 05:23 PM
it was fun to see, and I offer up this link for entertainment purposes only
Great clip. Interesting info to me: they say low insulin levels kick off the survival genes: a great reason to limit the protein in diet to 1-1.5(2)G per KG/bodyweight (hold off with the 30G+ protein shakes and the massive steak) to limit insulin secretion, due to the breakdown product from protein, and focus more on LOW glycemic carbs and healthy fats for longer life.
Climbing the genealogical tree, I see my family surviving better on lower protein-caloric diets, - my little brother is not really on a super healthy, balanced diet, but he probably hasn't eaten much protein in his life, - being rail-thin and not really looking so old.
#168
Posted 11 January 2007 - 07:06 AM
Edited by Matt, 11 January 2007 - 07:17 AM.
#169
Posted 11 January 2007 - 07:27 AM
Peanuts also are a high source of resveratrol as well.
#170
Posted 11 January 2007 - 06:14 PM
Stephen
#171
Posted 11 January 2007 - 07:02 PM
#172
Posted 11 January 2007 - 10:03 PM
Stephen
#173
Posted 16 January 2007 - 01:03 AM
I will tell you this. Two weeks ago, I took my Resveratrol along with a dose of Curcumin/Bioperine and it made me feel "agitated" for some reason. Has anyone experienced this?
Also, is it true that pairing Resveratrol with Quercitin negates the effects of Resveratrol. I read a while back that the metabolites of Quercetin may block the benefits of Resveratrol. Does anyone have any input on this?
I do notice that if I pair my Resveratrol with quercetin and lecithin that I feel a more positive mood and more endurance in my workouts. Does anyone feel this?
#174
Posted 16 January 2007 - 07:21 AM
It may or may not be helpful to you.
I currently take resveratrol, ellagic acid, lecithin, grape extract, and quercetin together with a glass of wine with dinner. The positive mood / energy effects are very pronounced, and consistent (and are present whether I drink the wine or not... so alcohol is not the cause). I feel less tired, and have more drive and enthusiasm. Maybe it's all in my head, but hey, its real and helps me so that is all that matters.
#175
Posted 16 January 2007 - 08:22 AM
It's been fairly well establised that resveratrol is the main ingredient that does the job.
No, it hasn't.
#176
Posted 16 January 2007 - 04:17 PM
BTW, Sardi's latest article on resveratrol:
http://tinyurl.com/y7xtql
#177
Posted 16 January 2007 - 05:10 PM
One finding that has often been overlooked is that quercetin, which is also present in red wine, is a picomolar inhibitor of resveratrol sulphation in both the liver and duodenum, indicating that the profiles of metabolites obtained after consumption of either red wine or purified resveratrol could be different.
It is also worth considering the potential interactions of resveratrol with other constituents of the diet. Resveratrol has been shown to synergize with both quercetin and ellagic acid in the induction of apoptosis in human leukaemia cells, with ethanol in the inhibition of iNOS expression, with vitamin E in the prevention of lipid peroxidation, with catechin in the protection of PC12 cells from beta-amyloid toxicity, and with nucleoside analogues in the inhibition of HIV1 replication in cultured T lymphocytes. These effects could help to explain how a relatively low dose of resveratrol obtained from red wine or other dietary sources could produce a measurable health benefit.
so do you still think that resveratrol is the only compound that would explain the french paradox. It's not that simple. We are talking multicellular systems and multifactorial mechanisms.
The source of the above quotes. I'm not quiet sure why people aren't reading this paper considering the amount of jibber jabber I've seen about resveratrol.
Oh yes, Duke, I started to read Bill Sardi's recent artcle
Living On the Vine
Human lifespan
Human lifespan over the centuries
Did anyone really find the secret of longevity long ago? The answer is, maybe. Lacking a time-reversal machine, this can only be speculated. But a review of the subject is certainly intriguing.
Moses lives 120 years
Biblical records.......
I stopped just before he could start quoting the bible. On purpose of course. [thumb]
#178
Posted 16 January 2007 - 05:38 PM
#179
Posted 16 January 2007 - 07:01 PM
I've noticed a stimulant effect with res when I started taking it though I've gotten used to it now. I recently upped my dose from 20mg to 40mg per day and found it harder to get to sleep and to sleep well. I'm hoping it will wear off or that I'll get used to it after a while. I can only imagine taking 400mg a day like some folks.
#180
Posted 16 January 2007 - 07:18 PM
What I said was res was the main ingredient that gave the benefits. I never said it was the only good thing out there or the only good thing in wine or grapes. Opales came up with a rip snorting "no it isn't" to refute my statement but that has been quietly rebutted by the facts. It's hard to argue with a study that used pure res and got the results we've all heard about.
And what animal was used in these studies?
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