I suffer from fibromyalgia and CFS. A while back I attempted to do the methylation protocol using methyl b12 and methyl folate. I experienced an initial feeling of warmth and euphoria for a couple of days and all my aches and pains disappeared and I had much energy. I thought I had at last discovered the cure to my condition. Then I started feeling sick with very painful points in my scalp, back and rib cage and my neck got painful and stiff along with sinus pain. My fibromyalgia flared up with tender points getting worse. I tried to isolate the problem and discovered that both supplements wee causing the reaction with B12 more so. I experimented with different brands and different forms like hydroxy-cobalamin, hydroxo-cobalimin, cyano-cobalamin, etc but they all produce the same reaction. I tried taking tiny dosages of B12 but again after a few days the bad effect builds up. Interestingly adenosylcobalamin did not produce any reactions, nor did regular folic acid, although I did not experiment with these very long.
I am hoping that someone can shed some light on these negative reactions. I am aware of the former Dr. Carl Pfeiffer recommending against B12 and folate for histadelia and I am wondering if what I experienced was a build up of histamine.
Thanks