Pharmacokenetics of C60 Hydrated Fullerenes vs C60 in Olive Oil.
We are in the initial stage of discussions with Dr Iryna Pishel about adding pristine C60 Hydrated Fullerenes to the ongoing longevity experiment with C60OO at the Kyiv Institute of Gerontology, started by the French researchers.
The pharmacokenetics and possibly the biodistribution of C60OO vs C60 Hydrated Fullerenes appear to be radically different.
For one, the concentration of C60 in C60OO in the Baati study was 0.8 mg/ml or administered at a dose of 4 mg/KG of body weight, whereas C60 HyFNs concentration is 0.0002 mg per 100ml. C60 does not dissolve as well in Olive oil as it does in the hydration process, that creates C60 Hydrated Fullerenes. Simple chemistry will tell you that macro doses of C[60] in mgs will likely have far different pharmacokinetic effects in the body then nano doses of C[60]
The Baati/ Moussa paper goes on to summarise: “Pharmacokinetic studies show that dissolved C[60] is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours.” In addition, at that concentration C[60] in Olive Oil aggregates and forms crystals in the spleen, liver, lungs and kidney cells.
Added to that, Olive Oil is poor medium, it is inconstant in moisture levels from year to year, dependant on the stage in growing season and cultivar to cultivar and goes rancid quickly. So that the C[60] water clusters that are eventually formed within Olive Oil would likely be variable and inconsistent in size, but it still has a positive longevity and health effects as we know.
From 2 Clinical studies done by Dr Andrievsky, C[60] hydrated fullerenes at 0,0002 mg per 100 ml stay in the body much longer then tens of hour. It may well be up to 2-3 months (since the repeat prophylactic regime is very 2-3 months) and it is a strong liver protector or hepatoprotector and doesn’t form crystals in your organs. So just that difference alone, would indicate that the pharmacokinetics and possibly biodistribution should be quite different, resulting in possibly an even greater lifespan extension then 90% that we see in the Baati/Moussa University of Paris study.
Clinical Studies with C60 Hydrated Fullerenes on Hepatitis C and Duodenum Ulcers
http://www.ipacom.co...en/research/104When it starts, I'm looking forward to the longevity study to see C60 Hydrated Fullerenes matched up with C60-OO
Edited by Walter Derzko, 02 April 2015 - 01:44 PM.