Thank you very much Kelvin!
You really helped me.
Just one more question and I will not bother you again:
On Fission (day 1) - 1 gram Nicotinamide
Do I have to take also 1g of Ribose or 1 gram Nicotinamide is enough?
Thank you!
Posted 29 April 2025 - 09:22 AM
Thank you very much Kelvin!
You really helped me.
Just one more question and I will not bother you again:
On Fission (day 1) - 1 gram Nicotinamide
Do I have to take also 1g of Ribose or 1 gram Nicotinamide is enough?
Thank you!
Posted 30 April 2025 - 12:09 AM
Thank you very much Kelvin!
You really helped me.
Just one more question and I will not bother you again:
On Fission (day 1) - 1 gram Nicotinamide
Do I have to take also 1g of Ribose or 1 gram Nicotinamide is enough?
Thank you!
That's easy: Save your time and money and skip the ribose.
You don't need it for the protocol.
Edited by Kelvin, 30 April 2025 - 12:10 AM.
Posted 30 April 2025 - 07:05 AM
Thank you Kelvin!
Posted 06 May 2025 - 09:24 AM
Could anyone please tell me if
Nicotinamide is the some as Niacinamide?
I need Nicotinamide for Mito protocol.
Thank you!
Posted 06 May 2025 - 05:47 PM
Could anyone please tell me if
Nicotinamide is the some as Niacinamide?
I need Nicotinamide for Mito protocol.
Thank you!
Yes it is.
Nicotinamide and niacinamide are two names for the same compound, a form of vitamin B3. They are chemically identical and have the same functions. Niacinamide is more commonly used in the skincare industry, while nicotinamide is the scientific name, often used in research and supplements.(google)
Posted 08 May 2025 - 01:03 PM
Thank you!
Posted 10 June 2025 - 12:09 PM
Now is there KL-1333, the first-in-class for NAD+.
The only one able to rescue people with primary mitochodrial diseases.
Posted 31 August 2025 - 11:01 PM
Remember to alternate between NMN and Nicotinamide for fission on SEPARATE days because although NMN causes fission in most of the body it causes fusion in the brain, while nicotinamide/NAM causes fission in the brain. If you take nicotinamide at the same time as NMN they cancel each other out for no brain benefit.
So do this
Fission (day 1) - 1 gram Nicotinamide
Fusion (day 2) - (AAKG is not necessary on fusion day if taking 1 gram of AKG - I use Double wood brand AKG)
Fission (day 3) - 1 gram NMN
Fusion (day 4) - normal fusion stack
Fission (day 5) - 1 gram Nicotinamide
etc, etc
Yes you can take TMG.
I usually take 2 grams TMG every 3- 4 mito cycles to restore methyl stores that are depleted by NMN and NAM.
Is it ok to use NR instead NMN for the same benefit? Same amount, 1gram?
Also, shouldn't PQQ be added on fusion days along with the AKG?
Edited by ekaitz, 31 August 2025 - 11:10 PM.
Posted 03 September 2025 - 08:42 PM
Is it ok to use NR instead NMN for the same benefit? Same amount, 1gram?
Also, shouldn't PQQ be added on fusion days along with the AKG?
Nicotinamide and NMN appear to have different effects.
Both I and others have noticed greater muscle tone when using NMN for fission relative to nicotinamide. NMN also has other benefits that nicotinamide does not such as improving insulin sensitivity in diabetics and prediabetics.
Since they have different affects, they probably affect mitochondria differently and so I rotate them on fission days just to be sure I am affecting as much mitochondria as possible.
Dosage is 1 gram nicotinamide (since using more than that doesn't appear to improve results) and at least 750 mgs of NMN, sometimes 1 gram NMN.
For PQQ I don't think it is necessary to use it more than 1 every 4 fission cycles to eliminate stray epigenetically damaged mitochondria that escaped the fission protocol days that didn't use PQQ.
I don't use it more because (based on Turnbuckle's description of mitochondrial latching) PQQ increases mitochondrial numbers and, since the C60 protocol works by affecting mitochondrial morphology, I don't want excessive PQQ use to potentially negatively affect the C60 protocol when I use it.
I forget the reason Turnbuckle used PQQ on fusion days, but I haven't noticed any improvement when using it on fusion. So I just use PQQ on fission days, and this seems to work just fine.
Edited by Kelvin, 03 September 2025 - 08:47 PM.
Posted 10 September 2025 - 11:09 AM


Posted 08 October 2025 - 12:47 PM
Posted 08 October 2025 - 01:10 PM
Since cancer is a mitochondria disease could this work for my father?
I'm trying the old protocol with the niacinamide. Should the supps be dissolved in water? I'm unable to do so. Are the ingredients still bioavailable to the body? Thank you.
If I come down with cancer, it will be a dog dewormer I reach for called panacur C. (Fenbendazole) I have personally seen a before and after PET scan of someone my wife knew. His cancer doctor told him " I know it's not the chemo doing this"
Hope this helps. I wish you both the best
Posted 08 October 2025 - 02:01 PM
Since cancer is a mitochondria disease could this work for my father?
I'm trying the old protocol with the niacinamide. Should the supps be dissolved in water? I'm unable to do so. Are the ingredients still bioavailable to the body? Thank you.
also check all thomas seyfried studies "cancer as a metabolic and mitochondrial disease" this is what i would do, ketogenic diet or carnivore, a lot of fasting and glutamine blockers ((Fenbendazole)
the protocol on this page is ofr antiaging i dont think it helps with cancer too much damage/too late for this protocol
Posted 08 October 2025 - 06:09 PM
Since cancer is a mitochondria disease could this work for my father?
I'm trying the old protocol with the niacinamide. Should the supps be dissolved in water? I'm unable to do so. Are the ingredients still bioavailable to the body? Thank you.
Also, reishi mushroom is something I'd be taking
Posted 27 October 2025 - 07:10 PM
Since cancer is a mitochondria disease could this work for my father?
I'm trying the old protocol with the niacinamide. Should the supps be dissolved in water? I'm unable to do so. Are the ingredients still bioavailable to the body? Thank you.
The development of cancer can be initiated by mitochondrial dysfunction. However, restoring mitochondrial health might not be sufficient to treat cancer because there are so many complex pathways involved and much depends on the type of cancer and how advanced it is.
Also, I think Turnbuckle did not recommend the mito protocol for those with cancer since he said fission might help cancer proliferate faster.
I don't know anything at all about Fenbendazole.
If I had cancer, I would still follow a standard course of cancer treatment unless the prognosis were very poor.
If the prognosis was not poor, then I would take the following anti-cancer supplements in addition to taking the standard medical treatments (Keep in mind this is what I would take, I cannot promise any cancer patient the following would be successful for their situation) -
100 mgs Sulforaphane at least 3 times a week (taken with a spoonful of brown mustard to activate the sulforaphane). Thorne Research is the best product available.
300 mgs Tocotrienols at least 3 times a week (from a brand that does not have include any tocopherols, especially alpha-tocopherol because they interfere with tocotrienol abosrbition). I use Swanson vitamin tocotrienols.
1 gram IP6 at least 3 times a week(Helps starve cancer cells of iron which they need at a higher rate than healthy cells)
300 mgs Resveratrol + 300 mgs of grapeseed extract at least twice a week.
250 mgs Pterostilbene at least twice a week.
1 gram Curcumin at least once a week.
1 gram Quercetin at least once a week.
1 gram Fisetin at least once a week.
I would try not to take everything on the same day, and spread them out, so I don't put too many supplements in my body at once.
Edited by Kelvin, 27 October 2025 - 07:12 PM.
Posted 28 October 2025 - 09:59 PM
Posted 28 October 2025 - 11:37 PM
Posted 30 October 2025 - 05:28 AM
Edited by bullGenteel, 30 October 2025 - 05:33 AM.
Posted 21 December 2025 - 03:20 PM
Hi, all, i have been missing for a long time since i had to address a large humeral osteonecrosis stage 1 and a completely ruptured subscapularis tendon, i could heal tendon simply by a carnivore diet plus prp injections (without the diet prp and supplements didn t work) and osteonecrosis has no symptoms now. it is getting smaller year after year while tendon is now perfect, only some scar tissue still visible on 2024 mri but insertion on bone is perfect
so i want to try mito protocols again especially to experiment before trying on my mother 82yo who's having atrial fibrillation, which is mainly correlated to mito damage, and try to reverse Afib or lower anti arrhythmia drug which blocks beta cells in the pancreas and makes a slow insulin response after meals. her glucose after a meal is low 110-114mg/dl on ketocarnivore diet, but it stays like that for more than 2 hrs and i really dont like this slow insulin response (no insulin resistance or other metabolic issues 99% it is the drug side effects)
i dont understand new turnbuckle protocols, linkedin posts are very brief and with new stuff i dont know like uplatching and downlatching...anyway i hope you can help me avoid mistakes
i started today by using 2g AAKG + 100mg PQQ and felt a lot of energy immediately. i take other supplements like magnesium, vitamina d, arginine, collagen, vit k2 mk4 and so on, not supplements used for fission, fusion and so on.
should i stop them on the days of these protocols to avoid intereference or just keep them many hours apart?
after increasing mito count by AAKG+PQQ can i go immediately to day 1 "nicotinamide 1g only" or "nicotinamide 1g+1g AAKG+20mg PQQ" still good?
day 2 fusion 300mg DHM, 1g AAKG, and 20mg PQQ, are they all needed?
i have liposomal nmn now shall i take 1g or maybe 500mg liposomal will be ok?
thank you
Edited by lost69, 21 December 2025 - 03:51 PM.
Posted 24 December 2025 - 05:42 PM
I haven't tried the new latching mitochondrial protocol. He says on Linkedin that the latching protocol (because of its large dose of PQQ) may increase the number of mitochondria over an extended period of time (hence your energy boost), therefore he does not recommend using it frequently since the energy boost should last a while without additional cycles.
For your mother, NMN improves insulin responses more than other NAD+ boosters. She may want to try the older mito protocol but substitute NMN for Nicotinamide on fission days.
Since you have osteocarcinoma, and Turnbuckle didn't recommend the previous Fission-Fusion mito protocol for those with cancer because fission might increase cancer growth, did you ever try the mito protocol (or C60 protocol) and did it reduce, increase, or have no effect on the cancer?
Edited by Kelvin, 24 December 2025 - 05:43 PM.
Posted 24 December 2025 - 06:50 PM
No mention of "cancer" was made in post 2329.
Posted 24 December 2025 - 08:43 PM
I haven't tried the new latching mitochondrial protocol. He says on Linkedin that the latching protocol (because of its large dose of PQQ) may increase the number of mitochondria over an extended period of time (hence your energy boost), therefore he does not recommend using it frequently since the energy boost should last a while without additional cycles.
For your mother, NMN improves insulin responses more than other NAD+ boosters. She may want to try the older mito protocol but substitute NMN for Nicotinamide on fission days.
Since you have osteocarcinoma, and Turnbuckle didn't recommend the previous Fission-Fusion mito protocol for those with cancer because fission might increase cancer growth, did you ever try the mito protocol (or C60 protocol) and did it reduce, increase, or have no effect on the cancer?
thanks i'll check the older protocol
no i dont have osteocarcinoma but osteonecrosis which is death of bone tissue due to lack of blood flow in that area during a trauma (in my case also due to a drug that weakens bones), that is impossible to stop or repair at my age but i could stop it and reverse some of the damage.
maybe i will try stemcells too later this year if the area is stil big on mri
i used gdf11 in the past which gave me a lot of real immediate results, about 8-9 years epigenetic age reversal, vocal range increased like in my 30 that allowed me to easily sing most difficult heavy metal/rock songs in impossible ranges for men and women and easily use also whistle range with a lot of power, less grey hair and many many other stuff like swimming butterfly for 3 hrs feeling no tiredness but the vocal range was such an immediate thing which is absolutely impossible in those high notes as you age
i also tried turnbuckle protocols, both mito and stemcells but i felt little to no effect compared to gdf11 and epigenetic age worsened to about 4 years younger
than i had the trauma on my shoulder and i stopped all protocols to be safe on the bones and tried everything to reverse bone edema, bone osteonecrosis and tendons ruptures (no surgery)
i'd like to try gdf11 and klotho in the future when osteonecrosis is completely reversed especially to be able to sing like that again
Edited by lost69, 24 December 2025 - 08:49 PM.
Posted 25 December 2025 - 10:18 PM
Edited by bullGenteel, 25 December 2025 - 10:28 PM.
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