Just a comment that I notice many are dismayed at the perceived 'lack of results' of NR supplementation in this study. I think much of this pessimism comes from the false concept that humankind will discover the 'Miracle Pill' that will alternatively save us (without further effort) from obesity, diabetes, muscle wasting, cellular dysfunction, etc., and on and on... simply on the basis of it being there in our heart, liver, blood, muscles, where ever.
I don't think NR is that miracle pill. It is an important substance for optimal homeostasis. Our body will use up to a maximum of what is needed, then dispose of the rest. Need more, then use more, dispose of less. That maximum level depends on any body's overall vigor, i.e., strength and stamina before exhaustion. The study says "Participants were healthy as determined by laboratory results, medical history, and physical examination." So normal everyday people, just older. One definition of better health is better physical vigor. This study used people of healthy vigor, but NOT specifically trying to improve their physical performance.
Ergo, the results they got. I do think they got healthier for taking NR, but it's not going to magically turn them into super strong or anything else ... old people. That is, unless they get more active, stronger, and so use more bodily energy to do it. Actually, that there was any strength difference between the two dosage levels is more surprising. There were no fitness classes offered during the study! Why would they get stronger? Because they took a pill? I'd venture the X2 group was just eking out the last little (single digit %) bits of strength their muscles had in them thanks to excess NAD+.
Hopefully these first 'baby step' studies showing proven NAD+ increases will lead to ones designed to show us where extra NAD+ can facilitate participants physical improvements. That takes time, personal workout time, AND perhaps NR. Just popping a pill and expecting miracles at 60+ yr old without effort, now would truly be a real miracle.
I wonder how many of us taking NR do have (N=1) positive stories of physical fitness improvements beyond the norm? Those types of results could be the precursors to encourage further research where NR supplementation could be really useful for the everyday Jane or Joe getting older.
Edited by Oakman, 30 November 2017 - 09:58 PM.