Looking for clinical trials for mitochondrial myopathy, I stumbled upon this [1] clinical trial
Study Type: Interventional Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science Official Title: Effects of Low Level Carbon Monoxide Preconditioning on Human Mitochondrial Biogenesis in Aortic Valve Surgery Patients
Doing some searching, there are a few human studies on Carbon Monixide and mitochondrial biogenesis. This one [2] seems interesting
Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans
Michael A. Rhodes , Martha Sue Carraway , Claude A. Piantadosi , Crystal M. Reynolds , Anne D. Cherry , T. E. Wester , Michael J. Natoli , E. Wayne Massey , Richard E. Moon , Hagir B. SulimanAmerican Journal of Physiology - Heart and Circulatory PhysiologyPublished 1 July 2009Vol. 297no. 1,H392-H399DOI: 10.1152/ajpheart.00164.2009
These findings provide evidence linking the HO/CO response involved in mitochondrial biogenesis in rodents to skeletal muscle in humans through a set of responses involving regulation of the mtDNA transcriptosome and mitochondrial fusion proteins autonomously of changes in exercise capacity.
I have seen dosages between 100 ppm and 200ppm during 1 hour for anything between 2 weeks to 4 weeks.
Worth trying ?
[1] http://clinicaltrial...how/NCT01727167
[2] http://ajpheart.phys...97/1/H392.short