We all start our life in biological terms with the zygote, right? Once formed, the zygote multiplies many times to make you as a baby, ready to be born. Then, after you are born, you grow up, etc.
My question is, if there are some small chnages of the DNA, that happen after the hudge number of the cellular divisions, then does our genome change with the time? Moreover DNA damage accumulates with time, as an aging change. Can then happen so, that different cells in our body to have a slightly different genotype? For example the genotype of a random skin cell to differe in 0,000001% with the skin cell standing just next to it?
Do the cells, that we have today, have a different genotype from the zygote, that they originated? Because of the DNA damage accumulation, or the small mistakes during the DNA replication, during the cellular division? If so, can we know what was the genotype of the zygote, that staerted us? Is there a cell, that stayed completely unchanged, or can we "reverse changes" and make the zygote genotype again?
What do you think?